IL27, interleukin 27, 246778

N. diseases: 286; N. variants: 14
Disease: Crohn Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.170 GeneticVariation disease GWASCAT A Genome-wide Association Study Identifying RAP1A as a Novel Susceptibility Gene for Crohn's Disease in Japanese Individuals. 30500874 2019
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.170 GeneticVariation disease GWASCAT Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 26974007 2016
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.170 AlteredExpression disease BEFREE The IL-27 mRNA expression was increased in patients with active CD compared with inactive CD disease (P = 0.035). 27221243 2016
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.170 GeneticVariation disease GWASCAT Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. 26192919 2015
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.170 GeneticVariation disease BEFREE Association of IL-27 gene three polymorphisms with Crohn's disease susceptibility in a Chinese Han population. 25674271 2014
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.170 Biomarker disease BEFREE Comprehensive epistasis analyses for the known CD susceptibility genes NOD2, IL23R and IL27 were performed. 24223725 2013
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.170 GeneticVariation disease BEFREE We identified a significant enrichment of methylation changes within 50 kb of CD GWAS loci (8.6-fold [P = 0.021] in adults; 2.4-fold [P = 0.009] in adults and children combined), including IL-27, IL-19, TNF, MST1, and NOD2. 22021194 2012
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.170 Biomarker disease BEFREE IL-27 transcripts are significantly elevated in active Crohn's disease (CD) but not in ulcerative colitis (UC). 19686419 2009
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.170 Biomarker disease BEFREE IL-1beta, IL-6, IL-12, and IL-27 were higher in affected areas compared to unaffected ones in UC but not CD. 19657406 2009
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.170 AlteredExpression disease BEFREE Notably, increased expression of IL-23 and IL-27 transcripts in CD suggests a T helper 1-dominated immunologic function in this disease. 15674109 2005