IL27, interleukin 27, 246778

N. diseases: 286; N. variants: 14
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0042164
Disease: Uveitis
Uveitis
0.040 AlteredExpression disease BEFREE Decreased interleukin 27 expression is associated with active uveitis in Behçet's disease. 24887071 2014
CUI: C0042164
Disease: Uveitis
Uveitis
0.040 GeneticVariation disease BEFREE No significant association was found between uveitis and both KIAA1109-rs4505848 and IL27-rs4788084. 22876110 2012
CUI: C0042164
Disease: Uveitis
Uveitis
0.040 Biomarker disease BEFREE These results suggest that suppression of intraocular inflammation might be mediated through endogenous production of IL-27 and IL-10 by retinal cells, whereas SOCS proteins induced by IL-27 during uveitis may function to protect the neuroretinal cells from the toxic effects of pro-inflammatory cytokines. 21294722 2011
CUI: C0042164
Disease: Uveitis
Uveitis
0.040 Biomarker disease BEFREE These findings suggest that T(H)1 cells may mitigate uveitis by antagonizing the T(H)17 phenotype through the IFN-gamma-mediated induction of IL-27 in target tissue. 17496900 2007