IL27, interleukin 27, 246778

N. diseases: 286; N. variants: 14
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.370 Biomarker disease BEFREE Taken together, this study demonstrates a potential role for IL-27 in the treatment of prostate cancer. 31009295 2019
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.370 Biomarker disease BEFREE IL-30 silencing in PC-SLCs prevented lung metastasis in 73% of tumor-bearing WT mice and up to 80% in tumor-bearing IL-30KO mice. 31366386 2019
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.370 Biomarker disease BEFREE Here, we asked whether IL30 may favor prostate cancer progression by conditioning PCSLCs and assessed the value of blocking IL30 to suppress tumor growth. 29487200 2018
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.370 Biomarker disease BEFREE We, thus, investigated whether IL-27 may function as anti-tumor agent in human (h) PCa and analyzed the rationale for its clinical application. 24681516 2014
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.370 GeneticVariation disease BEFREE We applied the IL-27 gene delivery protocol in vivo utilizing sonoporation (sonodelivery) with the goal of treating and reducing the growth of prostate cancer at a bone metastatic site in vivo. 24028178 2013
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.370 Biomarker disease BEFREE We have explored the potential of a novel cytokine, interleukin-27 (IL-27), for inhibiting this malignant crosstalk, and have examined the effect of autocrine IL-27 on prostate cancer cell gene expression, as well as the effect of paracrine IL-27 on gene expression in bone and T cells. 23086758 2013
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.370 Therapeutic disease CTD_human We applied the IL-27 gene delivery protocol in vivo utilizing sonoporation (sonodelivery) with the goal of treating and reducing the growth of prostate cancer at a bone metastatic site in vivo. 24028178 2013
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.370 Biomarker disease BEFREE We also examined the potential of IL-27 gene delivery by sonoporation to treat and reduce the growth of prostate cancer in vivo. 21801027 2011
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.370 Therapeutic disease CTD_human We also examined the potential of IL-27 gene delivery by sonoporation to treat and reduce the growth of prostate cancer in vivo. 21801027 2011
Diabetes Mellitus, Insulin-Dependent
0.340 Biomarker disease BEFREE Our study reveals that IL-27 contributes to autoimmunity in NOD mice through multiple mechanisms and provides substantial evidence to support its pathogenic role in human T1D. 31801074 2019
Diabetes Mellitus, Insulin-Dependent
0.340 GeneticVariation disease BEFREE Most remarkably, we identify a common missense variant in IL27, associated with type 1 diabetes that results in decreased functional activity of the protein and reduced expression levels of downstream IRF1 and STAT1 in CD4+ T cells only. 28248954 2017
Diabetes Mellitus, Insulin-Dependent
0.340 Biomarker disease BEFREE IL-27 blockage delays the onset of diabetes in non obese diabetes mouse, but its role in type 1 diabetes (T1D) in human has not been reported yet. 23294976 2013
Diabetes Mellitus, Insulin-Dependent
0.340 Biomarker disease BEFREE The microarray data provided evidence that viral infection, and IL-27 and IL-9 cytokine signalling contributed to the onset of T1D in two of the quadruplets. 22108602 2012
Diabetes Mellitus, Insulin-Dependent
0.340 Biomarker disease CTD_human Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. 19430480 2009
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.330 Biomarker group BEFREE These results are promising, because they are relevant to developing a novel IL-27-based strategy that can treat both the tumor and the bone, by using this simple and effective sonodelivery method for treating prostate tumor bone metastases. 24028178 2013
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.330 Therapeutic group CTD_human These results are promising, because they are relevant to developing a novel IL-27-based strategy that can treat both the tumor and the bone, by using this simple and effective sonodelivery method for treating prostate tumor bone metastases. 24028178 2013
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.330 Biomarker group BEFREE Overall, our results suggest that IL-27 may be able to modify interactions between prostate tumor and bone microenvironment cells and thus could be used as a multifunctional therapeutic for restoring bone homeostasis while treating metastatic prostate tumors. 23086758 2013
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.330 Biomarker group BEFREE Our results suggest that IL-27 can be effective in reducing tumor growth and can help enhance accumulation of effector cells in prostate tumors in vivo. 21801027 2011
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.330 Therapeutic group CTD_human Our results suggest that IL-27 can be effective in reducing tumor growth and can help enhance accumulation of effector cells in prostate tumors in vivo. 21801027 2011
CUI: C0205734
Disease: Diabetes, Autoimmune
Diabetes, Autoimmune
0.300 Biomarker disease CTD_human Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. 19430480 2009
CUI: C0342302
Disease: Brittle diabetes
Brittle diabetes
0.300 Biomarker disease CTD_human Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. 19430480 2009
CUI: C3837958
Disease: Diabetes Mellitus, Ketosis-Prone
Diabetes Mellitus, Ketosis-Prone
0.300 Biomarker disease CTD_human Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. 19430480 2009
CUI: C4554117
Disease: Diabetes Mellitus, Sudden-Onset
Diabetes Mellitus, Sudden-Onset
0.300 Biomarker disease CTD_human Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. 19430480 2009
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.170 GeneticVariation disease GWASCAT A Genome-wide Association Study Identifying RAP1A as a Novel Susceptibility Gene for Crohn's Disease in Japanese Individuals. 30500874 2019
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.170 AlteredExpression disease BEFREE In both CD and UC, interleukin (IL)-12 (p40), IL-18, IL-21 and IL-27 transcript levels were higher than in Control. 28533995 2017