|
Degenerative polyarthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The Expressions of Dickkopf-Related Protein 1 and Frizzled-Related Protein Are Negatively Correlated to Local Inflammation and Osteoarthritis Severity.
|
30947534 |
2019 |
|
Degenerative polyarthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results indicate separate roles for the antagonists, where DKK1 and GREM1 had similarities in response to injury and in OA, with a different response for FRZB.
|
29526783 |
2018 |
|
Degenerative polyarthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Single nucleotide polymorphisms (SNPs) in frizzled-related protein (FRZB) have been associated with osteoarthritis, but their association with the risk of skeletal fluorosis has not been reported.
|
29785637 |
2018 |
|
Degenerative polyarthritis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Blocking NO production may inhibit the loss of the articular phenotype in OA by preventing downregulation of the expression of DKK1 and FRZB.
|
29165387 |
2017 |
|
Degenerative polyarthritis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of MMPs relevant to human OA in the synovium from CHECK study participants significantly correlated with expression of FZD1, FZD10, and FRZB mRNA.
|
28678406 |
2017 |
|
Degenerative polyarthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Moreover, DKK1 and FRZB negatively correlated with OA grading, while RUNX2 and IHH showed a significantly positive correlation with OA grading.
|
27428952 |
2016 |
|
Degenerative polyarthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Rare variants of sFRP3 are associated with osteoarthritis.
|
25846075 |
2015 |
|
Degenerative polyarthritis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Lack of the verapamil effects in LiCl-treated and FRZB-downregulated OA chondrocytes also suggested that verpamil suppressed Wnt signaling by inducing FRZB.
|
24658359 |
2014 |
|
Degenerative polyarthritis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Comparative expression pattern analysis revealed the involvement of catabolic enzymes (MMP1, -2, -13, ADAM10), chemokines (IL8, CCL2, CXCL2, CXCL12, CCXL14), and genes associated with cell death (TNFSF10, PMAIPI, AHR) and skeletal development (GPNMB, FRZB) including transcription factors (WIF1, DLX5, TWIST1) and growth factors (IGFBP1, -3, TGFB1) consistent with published data from human OA cartilage.
|
24635637 |
2014 |
|
Degenerative polyarthritis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
GREM1, FRZB and DKK1 mRNA expression were strongly decreased in osteoarthritis.
|
24286177 |
2013 |
|
Degenerative polyarthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings suggest that FRZB may serve an important role in determining hip shape and may modify the relationship between hip shape and OA.
|
22544526 |
2012 |
|
Degenerative polyarthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We then tested for the association of shape modes with OA susceptibility single-nucleotide polymorphisms (SNPs) of GDF5, FRZB, and DIO2.
|
21400473 |
2011 |
|
Degenerative polyarthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Findings of this collaborative analysis do not support the notion that FRZB rs7775 or rs288326 has any sizable genetic effect on OA phenotypes.
|
19479880 |
2009 |
|
Degenerative polyarthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
No statistical differences in osteoarthritis severity were seen between Frzb(-/-) mice and wild-type mice.
|
18819822 |
2009 |
|
Degenerative polyarthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
While power was limited for most studies to date, a meta-analysis of all published studies regarding the FRZB Arg324Gly polymorphism was performed for hip- and knee-OA separately.
|
18406176 |
2008 |
|
Degenerative polyarthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic association studies have identified a few consistent osteoarthritis susceptibility genes (FRZB, GDF5, and DIO2) that replicate across different populations.
|
18698177 |
2008 |
|
Degenerative polyarthritis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
The presence of a small degree of differential allelic expression in a low proportion (24%) of the individuals studied suggests that polymorphism in FRZB cis-acting regulatory elements can be discounted as a major factor that could influence the development of OA.
|
16889986 |
2007 |
|
Degenerative polyarthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Replication studies have confirmed association of functional sequence variations in the secreted frizzled-related protein 3 (FRZB) and asporin (ASPN) genes with osteoarthritis.
|
17762607 |
2007 |
|
Degenerative polyarthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recently, the FRZB Gly324 variant has been shown to have an attenuated ability to antagonize Wnt signaling and to be associated with an increased osteoarthritis risk.
|
17420170 |
2007 |
|
Degenerative polyarthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
No direct replication of previous OA association findings was obtained but the results suggest that the R324G SNP of the FRZB gene may have an effect in OA development in multiple joints, with a specific severe involvement of the hip in women.
|
17237116 |
2007 |
|
Degenerative polyarthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results indicate that genetic polymorphisms affecting knee OA vary between populations (Japanese versus Caucasian) and sexes and indicate a role for ASPN, COMP, FRZB, and COL2A1 in Caucasians.
|
17195216 |
2007 |
|
Degenerative polyarthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The presence of a small degree of differential allelic expression in a low proportion (24%) of the individuals studied suggests that polymorphism in FRZB cis-acting regulatory elements can be discounted as a major factor that could influence the development of OA.
|
16889986 |
2007 |
|
Degenerative polyarthritis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The present study demonstrated that WNTs and FRPs are differentially expressed in RA and OA synovium, and suggests an involvement in the pathology of these diseases.
|
16735027 |
2006 |
|
Degenerative polyarthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our data confirm findings of another study, that a rare haplotype with both Arg200Trp and Arg324Gly FRZB variants contributes to the genetic susceptibility to hip OA among Caucasian women, and that these polymorphisms may contribute to increased serum levels of proteins as biomarkers of OA.
|
16572458 |
2006 |
|
Degenerative polyarthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results confirm that the R324G variant of the FRZB gene is involved in OA and indicate a role of this variant in several generalized OA phenotypes.
|
15818669 |
2005 |