Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
The same markers were also expressed in a proportion of adenocarcinomas supporting the view that gastrin is important in the development of gastric cancer.
|
28980157 |
2018 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Although a substantial part of the gastric adenocarcinomas express gastrin and CCKBR, the role of gastrin in tumor development is not completely understood.
|
28109268 |
2017 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Gastrin induces expression of clusterin in adenocarcinoma cells.
|
28902909 |
2017 |
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We therefore investigated whether serum gastrin or CCK concentrations at baseline were associated with the incidence of gastric non-cardia adenocarcinomas (GNCA), oesophagogastric junctional adenocarcinomas (EGJA) or gastric carcinoid tumours over 24 years of follow-up in a study nested within the all-male Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study of Finnish smokers.
|
28369403 |
2017 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
One uninfected gastric cancer subtype was distinguished by upregulation of 3 genes with neuroendocrine (NE) function (CHGA, GAST, and REG4 encoding chromogranin, gastrin, and the secreted peptide REG4 involved in epithelial cell regeneration), implicating hormonal factors in the pathogenesis of a major class of gastric adenocarcinomas.
|
25517873 |
2015 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We show that gastrin, known to signal through the Gq/G11-coupled CCK2 receptor, induces SIK1 expression in adenocarcinoma cells, and that transcriptional activation of SIK1 is negatively regulated by the Inducible cAMP early repressor (ICER).
|
25384047 |
2014 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Spontaneously developed gastric adenocarcinomas in Japanese cotton rats and INS-GAS transgenic mice were included.
|
23389729 |
2013 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Studying menin and its complex interrelationship with gastrin may provide insight into tumor biology at the clinical level and in terms of basic cell biology (eg, the role of the epigenome in neuroendocrine cell proliferation), and lead to potential consideration of other targets that are known candidates for molecular-based therapies in other adenocarcinomas.
|
23639647 |
2013 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Therefore, the results support the contention that locally expressed gastrin may be involved in the tumorigenesis of gastric adenocarcinomas.
|
23544442 |
2013 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
We show that NR4A2 is a primary early transient gastrin induced gene in adenocarcinoma cell lines, and that NR4A2 expression is negatively regulated by inducible cAMP early repressor (ICER) and zinc finger protein 36, C3H1 type-like 1 (Zfp36l1), suggesting that these gastrin regulated proteins exert a negative feedback control of NR4A2 activated responses.
|
24086717 |
2013 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Gastrin upregulates the prosurvival factor secretory clusterin in adenocarcinoma cells and in oxyntic mucosa of hypergastrinemic rats.
|
21995960 |
2012 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Prognostic significance of gastrin expression in patients undergoing R0 gastrectomy for adenocarcinoma.
|
17922093 |
2007 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In terms of the clinical situation, MVD in the normal mucosa surrounding colorectal adenocarcinomas correlated with patient serum gastrin levels and HB-EGF expression.
|
16585174 |
2006 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Two human pancreatic cell lines, PAN1 and BXPC3, expressed gastrin at both the RNA and protein levels and are shown to be representative of human pancreatic adenocarcinomas in terms of gastrin expression.
|
15313900 |
2004 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
LHGDN |
We also found gastrin immunoreactivity in cell membranes of poorly-differentiated primary adenocarcinoma tissues and in liver metastases.
|
12174892 |
2002 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Indeed, autoradiographic studies have demonstrated cholecystokinin (CCK)-B/gastrin receptors not only in more than 90% of MTCs but also in a high percentage of small cell lung cancers, some ovarian cancers, astrocytomas and potentially a variety of adenocarcinomas.
|
10452322 |
1999 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
CTD_human |
Gastrin stimulates growth of colon cancer.
|
3952654 |
1986 |