|
Gastrinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, our data suggest the strongest gastrin response evoked by SACI indicates the definitive location in patients with gastrinomas.
|
31813923 |
2020 |
|
Gastrinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Excessive secretion of gastrin can now be effectively controlled with powerful proton pump inhibitors, but surgical management to control gastrinoma itself remains controversial.
|
31528093 |
2019 |
|
Gastrinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Meanwhile it is well established that the causative gastrinomas are almost exclusively localized in the duodenum and not in the pancreas, MEN1 gastrinomas occur multicentric and are associated with hyperplastic gastrin cell lesions and tiny gastrin-producing micro tumors in contrast to sporadic duodenal gastrinomas.
|
31521501 |
2019 |
|
Gastrinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Soon thereafter, he presented with symptoms and elevated gastrin levels suggestive of ZES prompting abdominal exploration with partial resection of the duodenum to remove gastrinoma tumor nodules.
|
31818296 |
2019 |
|
Gastrinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This article reviews the role of surgical and medical management in patients with Zollinger-Ellison syndrome (ZES) due to a gastrin-secreting neuroendocrine tumor (gastrinoma).
|
30098717 |
2018 |
|
Gastrinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A majority are designated as type I (related to autoimmune gastritis) and type II (related to gastrinoma) neoplasms that develop secondary to gastrin hypersecretion.
|
30098721 |
2018 |
|
Gastrinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Zollinger-Ellison syndrome (ZES) is a clinical syndrome characterized by gastric acid hypersecretion due to the ectopic secretion of gastrin by a gastrinoma, a neuroendocrine tumor (NET) which mostly develops in the duodenum and in the pancreas.
|
28949124 |
2018 |
|
Gastrinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A diagnosis of primary lymph node gastrinoma was defined as tumor confined to one or more resected peripancreatic lymph nodes, negative localization for any extra-nodal disease and normal gastrin postresection.
|
28705492 |
2017 |
|
Gastrinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
GFAP and other markers of enteric glial cells (eg, p75 and S100B), colocalized with gastrin in human duodenal gastrinomas.
|
28859856 |
2017 |
|
Gastrinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Her serum gastrin and chromogranin were elevated, and an underlying gastrinoma was suspected.
|
28446479 |
2017 |
|
Gastrinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Finally, we detected gastrin expression using three human cohorts with pancreatic endocrine tumors (pNETs) that have not been diagnosed as gastrinomas (in 9/34 pNETs from 6/14 patients with multiple endocrine neoplasia type 1, in 5/35 sporadic nonfunctioning pNETs, and in 2/20 sporadic insulinomas), consistent with observations made in mouse models.
|
26169832 |
2015 |
|
Gastrinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Data available so far indicate that well-defined assays for gastrin have significantly higher diagnostic sensitivity than CgA measurements in gastrinomas.
|
25861845 |
2015 |
|
Gastrinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, proper diagnosis of gastrinomas and other hypergastrinaemic diseases requires insight into cellular gastrin synthesis and peripheral metabolism, and also into the design of useful immunoassays.
|
19172694 |
2008 |
|
Gastrinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
It has been shown that, in contrast to sporadic duodenal gastrinomas, they are associated with hyperplastic gastrin cell lesions and tiny gastrin-producing microtumors less than 500 microm in diameter.
|
17890894 |
2007 |
|
Gastrinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A considerable subset of tumors with immunohistochemical expression of gastrin but without evidence of ZES should be designated as functionally inactive NETs expressing gastrin, but not as gastrinomas.
|
17006979 |
2006 |
|
Gastrinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the perifusion system, high [Ca2+]o induced gastrin release from gastrinoma cells.
|
11787938 |
2001 |
|
Gastrinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Whether the density of the CaR is a determining factor of the magnitude of this gastrin release or plays a role in regulating the growth pattern of the gastrinoma, as it does in other cells, remains unclear at present.
|
11095444 |
2000 |
|
Gastrinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The presence or absence of methylation of the p16INK4a gene did not correlate with clinical characteristics of the gastrinoma, biological behavior (gastrin release and basal or maximal acid output), the presence or absence of known prognostic factors (tumor size, gastrinoma location, lymph node metastases, liver metastases, and curability), or growth pattern of the gastrinoma postresection.
|
11095446 |
2000 |
|
Gastrinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Gastrinomas are rare gastrin-secreting endocrine tumors that usually arise in the duodenum or pancreas and, if untreated, can cause severe peptic ulcers or metastatic disease.
|
11034099 |
2000 |
|
Gastrinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast to the normal pancreas and gastrinoma tumor, the aggressive behavior of pancreatic adenocarcinoma may be attributed to the autocrine production of gastrin and to the presence of its growth-related receptor.
|
9855703 |
1998 |
|
Gastrinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, because gastrin is not detectable in the normal human pancreas, the pancreatic ductal cell positivity for CD44 strengthened the ductal origin concept of gastrinomas.
|
7508823 |
1994 |
|
Gastrinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our data show that in situ hybridization is a sensitive method for gastrin mRNA detection and represents a valuable tool for the identification of gastrinomas.
|
1506673 |
1992 |
|
Gastrinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Both mRNAs and peptides of gastrin and chromogranin A were present in PT tumors.
|
1455308 |
1992 |
|
Gastrinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Expression of ACTH/POMC protein and mRNA was consistently associated only with malignant gastrinomas while gastrin protein, gastrin mRNA and Cgs/Sgs mRNAs were readily detected in both benign and malignant gastrinomas.
|
1285276 |
1992 |
|
Gastrinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In histologically normal and nonneoplastic pancreatic tissue from patients with duodenal (n = 3) and pancreatic (n = 2) gastrinomas the expression of gastrin was significantly higher-14.5 pmol/g (median), of which 28% was bioactive amidated gastrins.
|
2218398 |
1990 |