FUS, FUS RNA binding protein, 2521

N. diseases: 301; N. variants: 39
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0497327
Disease: Dementia
Dementia
0.380 Biomarker disease BEFREE Perturbation of these remarkable liquid phases can lead to aggregates, such as those formed by the proteins TDP-43 and FUS, which are linked to ALS and other dementia. 28176659 2017
CUI: C0497327
Disease: Dementia
Dementia
0.380 Biomarker disease BEFREE The multiple roles played by RNA binding proteins in neurodegeneration have become apparent following the discovery of TAR DNA binding protein 43 kDa (TDP-43) and fused in sarcoma/translocated in liposarcoma (FUS/TLS) involvement in amyotrophic lateral sclerosis and frontotemporal lobar dementia. 27015757 2016
CUI: C0497327
Disease: Dementia
Dementia
0.380 GeneticVariation disease BEFREE Blood sampling for the genetic assessment of mutations associated to primary dementias was performed as well: the genes investigated were FUS, C9Orf72, PSEN-1, PSEN-2. 25433797 2014
CUI: C0497327
Disease: Dementia
Dementia
0.380 GeneticVariation disease BEFREE The DNA/RNA binding proteins TAR DNA-binding protein 43 (TDP-43) and fused-in-sarcoma (FUS) are genetically linked to amyotrophic lateral sclerosis and frontotemporal lobar dementia, while the inappropriate cytoplasmic accumulations of TDP-43 and FUS are observed in a growing number of late-onset pathologies including spinocerebellar ataxia 3, Alzheimer's and Huntington's diseases (HD). 23172908 2013
CUI: C0497327
Disease: Dementia
Dementia
0.380 Biomarker disease BEFREE The DNA/RNA-binding proteins TDP-43 and FUS are found in protein aggregates in a growing number of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and related dementia, but little is known about the neurotoxic mechanisms. 22848727 2012
CUI: C0497327
Disease: Dementia
Dementia
0.380 Biomarker disease BEFREE Our FUS transgenic rats would be useful to the mechanistic study of cortical dementia in FTLD. 22833456 2012
CUI: C0497327
Disease: Dementia
Dementia
0.380 Biomarker disease BEFREE TDP-43 or FUS/TLS misaccumulation seems central not just to ALS (where it is found in almost all instances of disease), but more broadly in neurodegenerative disease, including frontal temporal lobular dementia (FTLD-U) and many examples of Alzheimer's or Huntington's disease. 21813273 2011
CUI: C0497327
Disease: Dementia
Dementia
0.380 GeneticVariation disease BEFREE This work further explores the spectrum of FUS mutations in patients with FALS and patients with FALS with features of frontotemporal dementia (FALS/FTD) or parkinsonism and dementia (FALS/PD/DE). 20668259 2010
CUI: C0497327
Disease: Dementia
Dementia
0.380 Biomarker disease GENOMICS_ENGLAND Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6. 19251628 2009
CUI: C0497327
Disease: Dementia
Dementia
0.380 Biomarker disease GENOMICS_ENGLAND