|
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These include MDM2 and CDK4 amplification in well-differentiated and dedifferentiated liposarcomas as well as FUS-DDIT3 rearrangements in myxoid liposarcoma.
|
30793229 |
2019 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The identification of signature cytogenetic and molecular alterations for certain lesions, such as PLAG1 gene rearrangement in lipoblastoma and FUS-DDIT3 fusion in myxoid liposarcoma, has been helpful in approaching these neoplasms and aiding in confirming the diagnosis.
|
30850231 |
2019 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
FUS-CHOP Promotes Invasion in Myxoid Liposarcoma through a SRC/FAK/RHO/ROCK-Dependent Pathway.
|
29190494 |
2018 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
FUS-DDIT3 dependency and biological function of the IGF-IR/PI3K/Akt signaling cascade were analyzed using a HT1080 fibrosarcoma-based myxoid liposarcoma tumor model and multiple tumor-derived myxoid liposarcoma cell lines.
|
28637688 |
2017 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This fusion gene as a hallmark of MLPS is very useful for differential diagnosis from other soft tissue sarcomas, and the associated protein, FUS-DDIT3, performs an important role in the phenotypic selection of targeted multipotent mesenchymal cells during oncogenesis.
|
29181103 |
2017 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
PRG4 is one of the downstream molecules of the myxoid liposarcoma (MLS)-specific fusion oncoproteins TLS-CHOP and EWS-CHOP.
|
28192118 |
2017 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Phase II study of amrubicin (SM-5887), a synthetic 9-aminoanthracycline, as first line treatment in patients with metastatic or unresectable soft tissue sarcoma: durable response in myxoid liposarcoma with TLS-CHOP translocation.
|
26897615 |
2016 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we studied a subgroup of sarcomas and leukaemias characterized by the FET (FUS, EWSR1, TAF15) family of fusion oncogenes, including FUS-DDIT3 in myxoid liposarcoma (MLS).
|
26865464 |
2016 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Establishment and characterization of a new human myxoid liposarcoma cell line (DL-221) with the FUS-DDIT3 translocation.
|
27270875 |
2016 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We report here two cases of myxoid liposarcoma containing unusual pleomorphic cells harboring FUS gene rearrangements.
|
27515548 |
2016 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We present 2 cases of liposarcoma arising in the vulva: a myxoid liposarcoma harboring DDIT3 and FUS rearrangements and a well differentiated liposarcoma/atypical lipomatous tumor harboring MDM2 amplification detected by fluorescence in situ hybridization.
|
25851712 |
2015 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Myxoid/round-cell liposarcoma (MLS/RCLS) is characterized by either the fusion gene FUS-DDIT3 or the less commonly occurring EWSR1-DDIT3 and most cases carry few or no additional cytogenetic changes.
|
25393000 |
2014 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To elucidate the mechanisms behind the high sensitivity of myxoid/round cell liposarcoma (MRCL) to trabectedin and the suggested selectivity for specific subtypes, we have developed and characterized three MRCL xenografts, namely ML017, ML015 and ML004 differing for the break point of the fusion gene FUS-CHOP, respectively of type I, II and III.
|
24213580 |
2014 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We report here a very rare case of myxoid/round cell liposarcoma of the paratesticular region with type 3 DDIT3-FUS fusion gene.
|
23276404 |
2013 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Specifically, endogenous mesenchymal stem cells (MSCs) expressing TLS:CHOP developed into MRCLS in vivo.
|
22293175 |
2012 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Translocated in liposarcoma-CCAAT/enhancer binding protein homologous protein (TLS-CHOP) (also known as FUS-DDIT3) chimeric oncoprotein is found in the majority of human myxoid liposarcoma (MLS), but its molecular function remains unclear.
|
22588557 |
2012 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Emerging phase 1 and 2 clinical data have shown high response rates in myxoid liposarcoma in part owing to the inhibition of the FUS-CHOP transcription factor.
|
21403840 |
2011 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Detection of myxoid liposarcoma-associated FUS-DDIT3 rearrangement variants including a newly identified breakpoint using an optimized RT-PCR assay.
|
20581806 |
2010 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The myxoid liposarcoma FUS-DDIT3 fusion oncoprotein deregulates NF-kappaB target genes by interaction with NFKBIZ.
|
18850010 |
2009 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the case of myxoid liposarcoma (MLS) tumors, the causative abnormality is a fusion between the CHOP transcription factor and the FUS or EWS genes.
|
19190116 |
2009 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
An amplification of the MDM2 and CDK4 genes respectively in the atypical lipomatous tumor/well-differentiated liposarcoma areas was detected by fluorescence in situ hybridization (FISH) analysis, and translocations of the CHOP and FUS genes were detected by FISH analysis in the myxoid/round cell liposarcoma areas.
|
18551309 |
2008 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, interphase FISH using DDIT3 and FUS probes identifies the characteristic translocation in myxoid liposarcoma.
|
18162764 |
2008 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Since the total number of patients is still limited, further studies are required to verify a putative association of type I FUS/DDIT3-fusion transcripts with a prognosis of MRCL.
|
17647282 |
2007 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Myxoid liposarcoma with cartilaginous differentiation: identification of the same type II TLS-CHOP fusion gene transcript in both lipogenic and chondroid components.
|
18091394 |
2007 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Taken together, our observations suggest that expression of FUS-CHOP may be the initiating event in myxoid liposarcoma pathogenesis, and that MPCs may constitute one cell type from which these tumors originate.
|
16849546 |
2006 |