|
Low-grade fibromyxoid sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Immunohistochemical analysis showed immunoreactivity for MUC4 and break-apart fluorescence in situ hybridization was positive for FUS rearrangement, confirming the diagnosis of LGFMS.
|
30632203 |
2019 |
|
Low-grade fibromyxoid sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the largest study of hybrid LGFMS-SEF tumors to date, all cases exhibited FUS rearrangements, a similar genetic profile to LGFMS.
|
29426275 |
2018 |
|
Low-grade fibromyxoid sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In some cases, areas indistinguishable from LGFMS are present, and these have been shown to contain FUS-CREB3L2 fusion transcripts.
|
28648941 |
2017 |
|
Low-grade fibromyxoid sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results of immunohistochemistry (MUC4 staining) and FUS gene rearrangement by fluorescence in situ hybridization confirmed the diagnosis of LGFMS.
|
28558780 |
2017 |
|
Low-grade fibromyxoid sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Primary intracranial low-grade fibromyxoid sarcoma with FUS gene rearrangement.
|
25828939 |
2015 |
|
Low-grade fibromyxoid sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
While the majority of LGFMS cases are characterized by a FUS-CREB3L1 fusion, both FUS-CREB3L2 and EWSR1-CREB3L1 fusions were recently demonstrated in a small number of LGFMS and SEF/LGFMS hybrid tumors.
|
25231134 |
2015 |
|
Low-grade fibromyxoid sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Both cases presented were confirmed to harbor FUS gene rearrangement, thereby confirming a diagnosis of LGFMS.
|
25416841 |
2015 |
|
Low-grade fibromyxoid sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We describe a case of superficial low-grade fibromyxoid sarcoma (LGFMS) in a 12-year-old boy, confirmed by the detection of FUS-CREB3L2 fusion transcripts by reverse-transcription polymerase chain reaction and FUS rearrangement with fluorescence in situ hybridization, which had morphological features similar to ossifying fibromyxoid tumor (OFMT), including an almost complete rim of mature, metaplastic bone.
|
25532939 |
2015 |
|
Low-grade fibromyxoid sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This fusion has recently been described as a variant translocation in low-grade fibromyxoid sarcoma (LGFMS), a tumor more typically characterized by a recurrent t(7;16) chromosomal translocation, resulting in the fusion of FUS and CREB3L2 genes.
|
24896634 |
2014 |
|
Low-grade fibromyxoid sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
All 5 cases of LGFMS with progression to SEF morphology or hybrid features had FUS-CREB3L2 fusion transcripts.
|
24441665 |
2014 |
|
Low-grade fibromyxoid sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fluorescent in situ hybridization (FISH) with a break-apart probe for FUS revealed the presence of a FUS gene rearrangement confirming the diagnosis of LGFMS.
|
24188507 |
2014 |
|
Low-grade fibromyxoid sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Deeply located low-grade fibromyxoid sarcoma with FUS-CREB3L2 gene fusion in a 5-year-old boy with review of literature.
|
25183312 |
2014 |
|
Low-grade fibromyxoid sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our findings therefore expand the spectrum of gene fusions that characterize LGFMS and suggest that the EWSR1 gene may substitute for the function of FUS in gene fusions of sarcoma.
|
23588368 |
2013 |
|
Low-grade fibromyxoid sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
MUC4-positive SEFs that lack FUS rearrangement may be related to LGFMS but could have alternate fusion partners, including EWSR1.
|
22982887 |
2012 |
|
Low-grade fibromyxoid sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In accordance with previous studies, our case showed positive findings of FUS rearrangement, reinforcing the notion of a close relationship between low grade fibromyxoid sarcoma and SEF.
|
22192807 |
2012 |
|
Low-grade fibromyxoid sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We evaluated cases of pure sclerosing epithelioid fibrosarcoma lacking areas of low-grade fibromyxoid sarcoma for FUS rearrangement to determine whether this entity could be related to low-grade fibromyxoid sarcoma.
|
22388756 |
2012 |
|
Low-grade fibromyxoid sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Whole-tissue sections of 309 tumors were evaluated: 49 LGFMSs (all with FUS gene rearrangement confirmed by fluorescence in situ hybridization), 40 soft tissue perineuriomas, 40 myxofibrosarcomas, 20 cellular myxomas, 20 solitary fibrous tumors, 20 low-grade malignant peripheral nerve sheath tumors, 20 cases of desmoid fibromatosis, 20 neurofibromas, 20 schwannomas, 20 monophasic synovial sarcomas, 20 cases of dermatofibrosarcoma protuberans, 10 myxoid liposarcomas, and 10 extraskeletal myxoid chondrosarcomas.
|
21415703 |
2011 |
|
Low-grade fibromyxoid sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We present a case of an ossifying tumor of the perineum that required an open biopsy and fluorescent in situ hybridization testing for FUS and CREB3L2 for diagnosis as a variant of low-grade fibromyxoid sarcoma.
|
21658743 |
2011 |
|
Low-grade fibromyxoid sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
RT-PCR and FISH for the FUS-CREB3L2 fusion transcript are useful tools for confirming LGFMS diagnosis, but have no role in predicting medium-term clinical outcome.
|
21406083 |
2011 |
|
Low-grade fibromyxoid sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our observed frequency of FUS rearrangement in superficial LGFMS is consistent with those published in the literature for more deeply seated lesions.
|
21399449 |
2011 |
|
Low-grade fibromyxoid sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
FUS-CREB3L2 was capable of activating transcription from CD24 regulatory sequences in luciferase assays, suggesting an important role for the upregulation of this gene in LGFMS.
|
21536545 |
2011 |
|
Low-grade fibromyxoid sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
By fluorescent in-situ hybridization (FISH) technique, the case with mixed SEF and LGFMS histology was positive for FUS rearrangement.
|
20499220 |
2011 |
|
Low-grade fibromyxoid sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fusion of the FUS and CREB3L2 genes in a supernumerary ring chromosome in low-grade fibromyxoid sarcoma.
|
20471519 |
2010 |
|
Low-grade fibromyxoid sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Postoperative pathology of the resected specimen revealed the tumor to be LGFMS based on its histological appearance, immunohistological staining, and evidence of fused in sarcoma (FUS) translocation by fluorescence in situ hybridization.
|
20628852 |
2010 |
|
Low-grade fibromyxoid sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
RT-PCR analysis revealed FUS-CREB3L2 fusion transcripts in 16 of the 19 (84%) LGFMSs.
|
18382348 |
2008 |