FUS, FUS RNA binding protein, 2521

N. diseases: 301; N. variants: 39
Disease: AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder) ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1842675
Disease: AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)
AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder) 		0.430 GeneticVariation disease UNIPROT Screening of SOD1, FUS and TARDBP genes in patients with amyotrophic lateral sclerosis in central-southern China. 27604643 2016
CUI: C1842675
Disease: AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)
AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder) 		0.430 GeneticVariation disease BEFREE Due to mutation, FUS protein became more rigid in nature and might alter the structural and functional behavior of protein and play a major role in inducing ALS6. 24738488 2015
CUI: C1842675
Disease: AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)
AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder) 		0.430 CausalMutation disease CLINVAR Activity-dependent FUS dysregulation disrupts synaptic homeostasis. 25324524 2014
CUI: C1842675
Disease: AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)
AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder) 		0.430 CausalMutation disease CLINVAR Extensive molecular genetic survey of Taiwanese patients with amyotrophic lateral sclerosis. 24908169 2014
CUI: C1842675
Disease: AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)
AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder) 		0.430 CausalMutation disease CLINVAR Characterization of FUS mutations in amyotrophic lateral sclerosis using RNA-Seq. 23577159 2013
CUI: C1842675
Disease: AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)
AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder) 		0.430 CausalMutation disease CLINVAR ALS-associated FUS mutations result in compromised FUS alternative splicing and autoregulation. 24204307 2013
CUI: C1842675
Disease: AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)
AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder) 		0.430 CausalMutation disease CLINVAR FUS mutations in sporadic amyotrophic lateral sclerosis: clinical and genetic analysis. 22055719 2012
CUI: C1842675
Disease: AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)
AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder) 		0.430 GeneticVariation disease BEFREE Mutations in FUS/TLS (fused in sarcoma/translated in liposarcoma) cause an inheritable form of amyotrophic lateral sclerosis (ALS6). 21965298 2012
CUI: C1842675
Disease: AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)
AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder) 		0.430 GeneticVariation disease UNIPROT Genetic contribution of FUS to frontotemporal lobar degeneration. 20124201 2010
CUI: C1842675
Disease: AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)
AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder) 		0.430 CausalMutation disease CLINVAR SOD1, ANG, VAPB, TARDBP, and FUS mutations in familial amyotrophic lateral sclerosis: genotype-phenotype correlations. 20577002 2010
CUI: C1842675
Disease: AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)
AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder) 		0.430 GeneticVariation disease UNIPROT Mutations of FUS gene in sporadic amyotrophic lateral sclerosis. 19861302 2010
CUI: C1842675
Disease: AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)
AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder) 		0.430 Biomarker disease BEFREE Our results indicated that changing FUS/TLS to an insoluble form may be a common process in polyQ diseases and ALS6. 19833157 2010
CUI: C1842675
Disease: AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)
AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder) 		0.430 CausalMutation disease CLINVAR Frameshift and novel mutations in FUS in familial amyotrophic lateral sclerosis and ALS/dementia. 20668259 2010
CUI: C1842675
Disease: AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)
AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder) 		0.430 CausalMutation disease CLINVAR ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import. 20606625 2010
CUI: C1842675
Disease: AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)
AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder) 		0.430 GeneticVariation disease UNIPROT Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis. 19251627 2009
CUI: C1842675
Disease: AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)
AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder) 		0.430 CausalMutation disease CLINVAR Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis. 19251627 2009
CUI: C1842675
Disease: AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)
AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder) 		0.430 GeneticVariation disease UNIPROT Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6. 19251628 2009