Red cell distribution width determination
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
RDW - Red blood cell distribution width result
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
Low density lipoprotein cholesterol measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
Serum LDL cholesterol measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
Serum total cholesterol measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
Neoplasms
|
0.060 |
GeneticVariation
|
group |
BEFREE |
Tumor-associated FUT3 promoter polymorphism rs2306969 (-6951 C> T, position related to the gene's translation start site) has been linked to breast, ovarian and intestinal gastric cancer.
|
30929162 |
2019 |
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Comparison of paired primary tumors/lymph node metastases revealed an increase of prolectin staining in metastasis and high FUT1 and FUT3 mRNA expression was associated with poor prognosis.
|
26908442 |
2016 |
Neoplasms
|
0.060 |
GeneticVariation
|
group |
BEFREE |
CA19-9 showed strong immunopositivity in most of the tumors (91.3%), and mutated enzyme FUT3 was demonstrated from the cases showing negative or weak staining.
|
27038681 |
2016 |
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
The non-expression of FUT3 was more frequent in larger lesions and also in HER2 negative IDC tumors.
|
26321244 |
2015 |
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Tumor necrosis factor-α (TNF-α) up-regulates FucT-III, resulting in increased sLeX in the airways of patients with respiratory disease; however, the mechanisms that regulate sLeX in the inflammatory tumor microenvironment are not well understood.
|
21437888 |
2011 |
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Together, our observations point to a tumor induced transcription of endothelial FUT1 and consequently an enhanced expression of CD174 which is involved in migration and early cell-cell contacts during tumor associated angiogenesis.
|
18205178 |
2008 |
Gastroesophageal reflux disease
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
The majority of patients who undergo a laparoscopic fundoplication for gastroesophageal reflux disease (GERD) have a structural (hiatal hernia, shortened lower esophageal sphincter [LES]) or functional (weak LES) defect of the gastroesophageal junction (GEJ).
|
31214803 |
2020 |
Gastroesophageal reflux disease
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Numerous studies demonstrate that POEM produces comparable, if not superior, results compared to standard laparoscopic Heller myotomy (LHM), as determined by LES pressure, dysphagia frequency, Eckardt score, hospital length of stay, therapy durability, and incidence of GERD.
|
31451984 |
2020 |
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
FUT3-fucosylated glycoconjugates play key roles in pathways involved in tumor biology and metastasis, such as cellular ligation to E-selectins, TGF-β-induced epithelial-mesenchymal transition, NK cell-mediated tumor cytotoxicity and apoptosis.
|
30929162 |
2019 |
Gastroesophageal reflux disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
The resting LES pressure was 8.9±5.94 mmHg with GER symptoms, 16.4±12.79 mmHg without GER symptoms, and 26.8±14.03 mmHg with achalasia.
|
29915812 |
2018 |
Gastroesophageal reflux disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
Gastro-esophageal reflux disease (GERD) may occur post-achalasia intervention due to disruption of the LES and therefore requires diligent follow-up, especially in children treated with POEM.
|
29439587 |
2018 |
Gastroesophageal reflux disease
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
There was a prevalence of acid reflux at both sphincters (p<0.0001); liquid reflux was prevalent at the LES (p=0.003) and mixed reflux at the UES (p=0.0001).
|
29307652 |
2018 |
Neoplasm Metastasis
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
Comparison of paired primary tumors/lymph node metastases revealed an increase of prolectin staining in metastasis and high FUT1 and FUT3 mRNA expression was associated with poor prognosis.
|
26908442 |
2016 |
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
E-selectin knockdown in EC-Bcl-2 cells or FAK/FUT3 knockdown in tumor cells significantly reversed EC-Bcl-2-mediated tumor metastasis.
|
26509633 |
2015 |
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Fucosylated glycans synthesized by α1,3/4-fucosyltransferase (FUT3) enzyme play an important role in breast cancer prognosis and metastasis, being involved in the binding of circulating tumor cells to the endothelium and being related to tumor stage, metastatic potential and chemoresistance.
|
26321244 |
2015 |
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
LHGDN |
Studies on mechanism of Sialy Lewis-X antigen in liver metastases of human colorectal carcinoma.
|
11819805 |
2001 |
Esophageal Achalasia
|
0.040 |
Biomarker
|
disease |
BEFREE |
Increased lower esophageal sphincter integrated relaxation pressure (LES-IRP) is a cardinal feature of achalasia.
|
30153516 |
2019 |
Esophageal Achalasia
|
0.040 |
Biomarker
|
disease |
BEFREE |
Yet, some patients exhibit clinical features of achalasia despite normal IRP and have LES dysfunction demonstrable by other means.
|
30957312 |
2019 |
Achalasia
|
0.040 |
Biomarker
|
disease |
BEFREE |
Yet, some patients exhibit clinical features of achalasia despite normal IRP and have LES dysfunction demonstrable by other means.
|
30957312 |
2019 |