FYB1, FYN binding protein 1, 2533

N. diseases: 30; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2678311
Disease: Thrombocytopenia 3
Thrombocytopenia 3 		0.600 Biomarker disease CTD_human
CUI: C2678311
Disease: Thrombocytopenia 3
Thrombocytopenia 3 		0.600 CausalMutation disease CLINVAR
CUI: C0040034
Disease: Thrombocytopenia
Thrombocytopenia 		0.130 Biomarker phenotype HPO
CUI: C0014591
Disease: Epistaxis
Epistaxis 		0.100 Biomarker phenotype HPO
CUI: C1096368
Disease: Decreased mean platelet volume
Decreased mean platelet volume 		0.100 Biomarker phenotype HPO
CUI: C1458140
Disease: Bleeding tendency
Bleeding tendency 		0.100 Biomarker phenotype HPO
CUI: C4021790
Disease: Abnormality of the skeletal system
Abnormality of the skeletal system 		0.100 Biomarker disease HPO
CUI: C0023524
Disease: Leukoencephalopathy, Progressive Multifocal
Leukoencephalopathy, Progressive Multifocal 		0.010 GeneticVariation disease BEFREE By applying subtraction cloning to acute promyelocytic leukemia cells, we identified a retinoic acid-induced gene, PRAM-1 (PML-RARalpha target gene encoding an Adaptor Molecule-1), which encodes a novel adaptor protein sharing structural homologies with the SLAP-130/fyb adaptor. 11301322 2001
CUI: C0043407
Disease: Yersinia infections
Yersinia infections 		0.010 Biomarker group BEFREE These yopH mutants were also clearly attenuated in virulence, showing that binding to p130Cas and/or Fyb is biologically relevant in Yersinia infections. 12542470 2003
CUI: C0162820
Disease: Dermatitis, Allergic Contact
Dermatitis, Allergic Contact 		0.300 Biomarker disease CTD_human Gene transcripts as potential diagnostic markers for allergic contact dermatitis. 16033404 2005
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.010 GeneticVariation phenotype BEFREE Individuals with the Duffy-negative phenotype are resistant to P. vivax invasion, and the molecular mechanism that gives rise to the phenotype Fy(a - b - ) in black individuals has been associated with a point mutation - 33TC expressed in homozigosity in the FYB allele [5]. 17607593 2006
CUI: C0024530
Disease: Malaria
Malaria 		0.030 GeneticVariation disease BEFREE The obtained data suggest that individuals with the FYA/FYB genotype have higher susceptibility to malaria. 18093292 2007
CUI: C0019163
Disease: Hepatitis B
Hepatitis B 		0.010 GeneticVariation disease BEFREE However, the emergence of antiviral drug-associated potential vaccine escape mutants (ADAP-VEMs) in treated patients does not necessarily pose a significant, imminent threat to the global hepatitis B immunization programme. 20428355 2010
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute 		0.010 Biomarker disease BEFREE Thus, SLP-76 and ADAP are involved in E-selectin-mediated integrin activation and neutrophil recruitment to inflamed kidneys, which may underlie the development of life-threatening ischemia-reperfusion-induced AKI in humans. 22291096 2012
CUI: C0040034
Disease: Thrombocytopenia
Thrombocytopenia 		0.130 GeneticVariation phenotype BEFREE This is the first report linking pathogenic variants in FYB and thrombocytopenia in humans. 25516138 2014
CUI: C0024530
Disease: Malaria
Malaria 		0.030 GeneticVariation disease BEFREE This data provide evidence that individuals with the FYA/FYB genotype have higher susceptibility to malaria and there are significant associations between Duffy blood group variants and susceptibility or resistance to vivax malaria. 24507640 2014
CUI: C0024537
Disease: Malaria, Vivax
Malaria, Vivax 		0.010 GeneticVariation disease BEFREE This data provide evidence that individuals with the FYA/FYB genotype have higher susceptibility to malaria and there are significant associations between Duffy blood group variants and susceptibility or resistance to vivax malaria. 24507640 2014
CUI: C2678311
Disease: Thrombocytopenia 3
Thrombocytopenia 3 		0.600 Biomarker disease GENOMICS_ENGLAND Deleterious mutation in the FYB gene is associated with congenital autosomal recessive small-platelet thrombocytopenia. 25876182 2015
CUI: C0005818
Disease: Blood Platelet Disorders
Blood Platelet Disorders 		0.310 Biomarker group GENOMICS_ENGLAND Deleterious mutation in the FYB gene is associated with congenital autosomal recessive small-platelet thrombocytopenia. 25876182 2015
CUI: C0040034
Disease: Thrombocytopenia
Thrombocytopenia 		0.130 GeneticVariation phenotype BEFREE Deleterious mutation in the FYB gene is associated with congenital autosomal recessive small-platelet thrombocytopenia. 25876182 2015
CUI: C0014070
Disease: Encephalomyelitis
Encephalomyelitis 		0.020 Biomarker disease BEFREE The adhesion- and degranulation-promoting adaptor protein and its role in the modulation of experimental autoimmune encephalomyelitis. 25746044 2015
CUI: C0011854
Disease: Diabetes Mellitus, Insulin-Dependent
Diabetes Mellitus, Insulin-Dependent 		0.010 GeneticVariation disease BEFREE The aim of this study was to perform an association study between seven Fyn-binding protein gene (FYB)-tag single nucleotide polymorphisms (SNPs) and type I diabetes mellitus (T1DM), as well as with disease age of onset. 25729932 2015
CUI: C0021400
Disease: Influenza
Influenza 		0.010 Biomarker disease BEFREE The Immune Adaptor ADAP Regulates Reciprocal TGF-β1-Integrin Crosstalk to Protect from Influenza Virus Infection. 25909459 2015
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.010 GeneticVariation group BEFREE It is critical to further explore whether the SNP polymorphisms located in human ADAP gene are associated with disease susceptibility in response to influenza virus infection. 25909459 2015
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.100 GeneticVariation disease GWASCAT Analysis of 23andMe antidepressant efficacy survey data: implication of circadian rhythm and neuroplasticity in bupropion response. 27622933 2016