|
Involutional Depression
|
0.300 |
Biomarker
|
disease |
CTD_human |
Altered neuro-inflammatory gene expression in hippocampus in major depressive disorder.
|
29175309 |
2018 |
|
Major Depressive Disorder
|
0.300 |
Biomarker
|
disease |
CTD_human |
Altered neuro-inflammatory gene expression in hippocampus in major depressive disorder.
|
29175309 |
2018 |
|
Involutional paraphrenia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Altered neuro-inflammatory gene expression in hippocampus in major depressive disorder.
|
29175309 |
2018 |
|
Psychosis, Involutional
|
0.300 |
Biomarker
|
disease |
CTD_human |
Altered neuro-inflammatory gene expression in hippocampus in major depressive disorder.
|
29175309 |
2018 |
|
Influenza
|
0.300 |
Biomarker
|
disease |
CTD_human |
A host transcriptional signature for presymptomatic detection of infection in humans exposed to influenza H1N1 or H3N2.
|
23326326 |
2013 |
|
Spontaneous abortion
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Gene expression in cultured endometrium from women with different outcomes following IVF.
|
18539642 |
2008 |
|
Abortion, Tubal
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Gene expression in cultured endometrium from women with different outcomes following IVF.
|
18539642 |
2008 |
|
Early Pregnancy Loss
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Gene expression in cultured endometrium from women with different outcomes following IVF.
|
18539642 |
2008 |
|
Miscarriage
|
0.300 |
Biomarker
|
disease |
CTD_human |
Gene expression in cultured endometrium from women with different outcomes following IVF.
|
18539642 |
2008 |
|
Hepatitis C
|
0.030 |
Biomarker
|
disease |
BEFREE |
Conclusion: A lncRNA, lncRNA-IFI6, regulates antiviral innate immunity in the JFH1 HCV infection model. lncRNA-IFI6 regulates HCV infection independently of the JAK-STAT pathway. lncRNA-IFI6 exerts its regulatory function via promoter activation and histone modification of IFI6 through its spatial domain.
|
30199576 |
2019 |
|
Hepatitis C
|
0.030 |
Biomarker
|
disease |
BEFREE |
Notably, IFI6 has little effect on other mammalian RNA viruses, including the related Flaviviridae family member hepatitis C virus, which replicates in double-membrane vesicles that protrude outwards from the ER.
|
30224801 |
2018 |
|
Lupus Erythematosus, Systemic
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
We identified 10 common marker genes associated with SLE (IFI6, IFI27, IFI44L, OAS1, OAS2, EIF2AK2, PLSCR1, STAT1, RNASE2, and GSTO1).
|
27257790 |
2016 |
|
Hepatitis C
|
0.030 |
Biomarker
|
disease |
BEFREE |
Taken together, the results from our study support a model where IFI6 inhibits HCV entry by impairing EGFR mediated CD81/CLDN1 interactions.
|
25757571 |
2015 |
|
Lupus Erythematosus, Systemic
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
By assessing DNA methylation levels across over 485,000 methylation sites across the entire genome, we further demonstrate that the lupus risk variant in this locus is associated with significant DNA methylation changes, including in the HLA-DR and HLA-DQ loci, as well as interferon-related genes such as IFI6, IRF6, and BST2.
|
23428850 |
2013 |
|
Lupus Erythematosus, Systemic
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The genes functions were related to a diverse cellular process including: (1) most of these genes were associated with CD4+ T cells functions, particularly related to cellular developments; (2) Ras pathway genes as RANBP10, GMIP, RASGRP2 and ARL5 might be responsible for the abnormal development of CD4+ T cells of SLE; (3) HIG2, TCF7, KHSRP, WWP1, SMAD3, TLK2, AES, CCNI and PIM2 belong to Wnt/beta-catenin way, they could play roles in modulating proliferation and differentiation of T lymphocytes; (4) uncertain viral infections may initiate autoimmunity because high levels expression genes were detected in T4-1s such as TRIM22, IER2, ABCE1, DUT, G1P2, G1P3, HNRPUL1, EVER2, IFNAR1, TNFSF14, TMP21 and PVRL2; and (5) apoptosis relating genes as EIF3S8, SH3BGRL3, GPX4, TOSO, PFDN5, BIN1, XIAPAF1, TEGT and CUGBP2 may contribute to over uploading of selfantigens in SLE cells.
|
16143398 |
2006 |
|
Malignant neoplasm of breast
|
0.020 |
Biomarker
|
disease |
BEFREE |
Therefore, interrupting mitochondrial functions of G1P3 may improve clinical outcomes in breast cancer patients.
|
29899394 |
2018 |
|
Breast Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Therefore, interrupting mitochondrial functions of G1P3 may improve clinical outcomes in breast cancer patients.
|
29899394 |
2018 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Emerging roles of FAM14 family members (G1P3/ISG 6-16 and ISG12/IFI27) in innate immunity and cancer.
|
20939681 |
2011 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Curtailing G1P3-mediated antiapoptotic signals could improve therapies for myeloma or other malignancies.
|
17823654 |
2007 |
|
Malignant neoplasm of breast
|
0.020 |
Biomarker
|
disease |
BEFREE |
Further analysis by EST vNorthern and virtual microarray analysis reduced the candidate genes to six, with four down-regulated genes, ANXA1, CAV1, KRT5 and MMP7, and two up-regulated genes, ERBB2 and G1P3 in breast cancer.
|
15647832 |
2005 |
|
Breast Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Further analysis by EST vNorthern and virtual microarray analysis reduced the candidate genes to six, with four down-regulated genes, ANXA1, CAV1, KRT5 and MMP7, and two up-regulated genes, ERBB2 and G1P3 in breast cancer.
|
15647832 |
2005 |
|
Dermatomyositis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PCR analysis showed that mRNAs of IFITM2, LY6E, DDX58, and IFI6 were expressed at significantly higher levels in the muscle tissue of patients with DM than in normal muscle tissues.
|
30383435 |
2018 |
|
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
G1P3-induced mtROS have a direct role in migratory structure formation and nuclear gene expression to promote breast cancer cell metastasis.
|
29899394 |
2018 |
|
Adult type dermatomyositis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PCR analysis showed that mRNAs of IFITM2, LY6E, DDX58, and IFI6 were expressed at significantly higher levels in the muscle tissue of patients with DM than in normal muscle tissues.
|
30383435 |
2018 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
G1P3-overexpressing cells migrated and invaded faster than the vector controls with increased number of filopodia and F-actin bundles (p ≤ 0.05). mtROS suppression with H<sub>2</sub>O<sub>2</sub> scavengers and mitochondrial-specific antioxidants significantly decreased migratory structures and reversed G1P3-induced migration and invasion (p ≤ 0.05).
|
29899394 |
2018 |