Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A SNP variant of rs279871, in the chromosome 4 gene encoding gamma-aminobutyric acid receptor (GABRA2), was selected due to its associations with alcoholism in young adults and with behaviors that increased risk for early drinking.
|
28847377 |
2017 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Genotyping of the 3 single nucleotide polymorphisms (SNPs) across the GABRA2 gene (rs567926, rs279858 and rs9291283) was performed in patients with alcohol dependence (N=654) and healthy control subjects (N=574).
|
26116794 |
2015 |
Alcoholic Intoxication, Chronic
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
This study examined correlates of in vitro gene expression of the AD-associated GABRA2 rs279858*C-allele in human neural cells using an induced pluripotent stem cell (iPSC) model system.
|
26250693 |
2015 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Variants in GABRA2 have been associated with adult alcohol dependence as well as phenotypic precursors, including impulsiveness and externalizing behaviors.
|
24975023 |
2014 |
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
PSYGENET |
Linkage studies of alcoholism have implicated several chromosome regions, leading to the successful identification of susceptibility genes, including ADH4 and GABRA2 on chromosome 4.
|
24692236 |
2014 |
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
PSYGENET |
In this study, we test for genetic effects of GABRA2, a gene previously associated with alcohol dependence, on trajectories of drunkenness from age 14 to 25.
|
23692184 |
2014 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Although the analysis provided nominal support for an association with rs9291283 and AAD in adulthood and CD in adolescence, the current study failed to replicate previous associations between two well replicated GABRA2 SNPs and CD and alcohol dependence.
|
24687270 |
2014 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this study, we test for genetic effects of GABRA2, a gene previously associated with alcohol dependence, on trajectories of drunkenness from age 14 to 25.
|
23692184 |
2014 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Linkage studies of alcoholism have implicated several chromosome regions, leading to the successful identification of susceptibility genes, including ADH4 and GABRA2 on chromosome 4.
|
24692236 |
2014 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We genotyped subjects for three SNPs previously associated with AD: rs279858 in GABRA2, and rs7654165 and rs6447493 in GABRG1.
|
24166645 |
2014 |
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
PSYGENET |
We used linear mixed models to examine the effects of dutasteride and alcohol on BAES and SS responses and the interaction of dutasteride with the GABRA2 alcohol dependence-associated polymorphism rs279858.
|
24557088 |
2014 |
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
PSYGENET |
Variants in GABRA2 have been associated with adult alcohol dependence as well as phenotypic precursors, including impulsiveness and externalizing behaviors.
|
24975023 |
2014 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We used linear mixed models to examine the effects of dutasteride and alcohol on BAES and SS responses and the interaction of dutasteride with the GABRA2 alcohol dependence-associated polymorphism rs279858.
|
24557088 |
2014 |
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
PSYGENET |
Although the analysis provided nominal support for an association with rs9291283 and AAD in adulthood and CD in adolescence, the current study failed to replicate previous associations between two well replicated GABRA2 SNPs and CD and alcohol dependence.
|
24687270 |
2014 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Variation in the GABA(A) α2 receptor subunit gene (GABRA2) has been associated with alcohol dependence (AD).
|
22501025 |
2013 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The current study examined the influence of gender, negative and positive daily life events, and GABRA2 genotype (SNP rs279871) on alcohol dependence, testing two- and three-way interactions between these variables using multi-level regression models fit to data from 2,281 White participants in the Collaborative Study on the Genetics of Alcoholism.
|
23974430 |
2013 |
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
BEFREE |
A few candidate genes such as GABRA2 have shown robust associations with alcoholism.
|
24091936 |
2013 |
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
BEFREE |
In addition, a gene encoding one of the receptors for the neurotransmitter γ-aminobutyric acid (GABA) known as GABRA2 seems to have a role in the development of alcohol dependence.
|
23134043 |
2012 |
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
CTD_human |
GABAergic gene expression in postmortem hippocampus from alcoholics and cocaine addicts; corresponding findings in alcohol-naïve P and NP rats.
|
22253714 |
2012 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Impulsiveness and insula activation during reward anticipation are associated with genetic variants in GABRA2 in a family sample enriched for alcoholism.
|
21483437 |
2012 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Moreover, polymorphisms in the GABRA2 gene encoding the GABA(A) receptor α2 subunit have been found to be linked to chronic alcohol dependence and to polydrug abuse.
|
22921455 |
2012 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The PubMed database and the HuGE Navigator were searched for published GAS-related variants in the GABRA2 gene with susceptibility to alcoholism.
|
22555154 |
2012 |
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
BEFREE |
To examine these associations in greater detail, we genotyped 13 single nucleotide polymorphisms (SNPs) spanning GABRG1 and GABRA2 in 380 AAs with AD and in 253 AA controls.
|
21919924 |
2012 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Based on a haplotypic association of alcohol dependence with GABRA2, we investigated whether GABRA2 alleles are associated with the subjective responses to clamped alcohol concentration.
|
21118274 |
2011 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Cerebellum volume in high-risk offspring from multiplex alcohol dependence families: association with allelic variation in GABRA2 and BDNF.
|
22047728 |
2011 |