GAD1, glutamate decarboxylase 1, 2571

N. diseases: 245; N. variants: 14
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 Biomarker disease BEFREE Primary outcome measures were assessed with the Generalized Anxiety Disorder Scale (GAD-7), Personal Health Questionnaire Depression Scale (PHQ-8), Perceived Stress Scale (PSS-14), and Pittsburgh Sleep Symptom Questionnaire-Insomnia (PSSQ-1). 29351138 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 Biomarker disease BEFREE They completed the Centre for Epidemiologic Studies Depression Scale (CES-D) and the General Anxiety Disorder Scale (GAD-7) to measure whether they experience depression and/or anxiety symptoms. 29543833 2018
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 Biomarker disease PSYGENET We also found suggestive associations in women for GAD1, GRIA3, and BDNF with depression accompanied by fatigue, and for CRHR1 with depression accompanied by early morning awakenings. 19548263 2010
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 Biomarker disease BEFREE Respectively 21.4% and 7.8% of the participants had depression and clinical symptoms of GAD. 30550597 2018
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 GeneticVariation disease BEFREE A binary logistic regression analyses were conducted to test the association between all four ratings in GAD-7 (anxiety) and PHQ-9 (depression) scales subitems as covariates, and migraine vs no headache as the outcome. 28324317 2017
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 Biomarker disease BEFREE Changes in DEMS correlated with changes in both PHQ-8 and GAD-7 in the subgroup of patients without prior depression or anxiety diagnosis (ρ = 0.6, P = 0.002; ρ = 0.4, P = 0.02). 30950896 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 Biomarker disease BEFREE Depression was more commonly studied (ranged from 1%-30%).Prevalence of GAD ranged from 1%-26%. 29966886 2018
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 Biomarker disease BEFREE Of the 336 usable responses, 16.1% scored 10 or greater on the PHQ-8 consistent with current depression while 17.3% scored 10 or greater on the GAD-7 consistent with current anxiety. 30637564 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 GeneticVariation disease BEFREE Participants were 307 psychiatry outpatients with depression; assessed at baseline, 3-, and 6-months on symptom (PHQ-9 and GAD-7), functioning (SF-12) and past-month marijuana use for a substance use intervention trial. 28242498 2017
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 GeneticVariation disease BEFREE The resulting groups were characterized with regard to Quality of Life (MacNew), anxiety and depression (GAD-7 and PHQ-9) and resilience (RS-13). 28006984 2017
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 Biomarker disease PSYGENET As a consequence broader entities such as depression-GAD spectrum, panic-phobias spectrum and OCD spectrum including eating disorders and pathological gambling are taken into consideration; (c) Diagnostic categories use thresholds to delimitate a border with normals.This creates "subthreshold" conditions. 18344044 2008
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 GeneticVariation disease BEFREE In a cross-sectional study, 23 patients with IPF were evaluated using Montreal Cognitive Assessment (MoCA), an instrument for detecting mild cognitive impairments and were screened for OSA through overnight cardiorespiratory polygraphy and for anxiety and depression with three specific scale (Generalized Anxiety Disorder 7-item scale: GAD-7; the Patient Health Questionnaire: PHQ-9; Hospital Anxiety and Depression Scale: HADS). 30707735 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 AlteredExpression disease BEFREE Self-report questionnaires were administered to assess quality of life (12-item Kansas City Cardiomyopathy Questionnaire quality of life subscale), level of anxiety (7-item Generalized Anxiety Disorder; GAD-7), level of depression (9-item Patient Health Questionnaire; PHQ-9) and device acceptance (Florida Patient Acceptance Survey; FPAS) to 101 consecutive patients presenting to LVAD clinic. 31346241 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 Biomarker disease BEFREE The PHQ-9 and GAD-7 were determined to be potential screening tools to aid Chinese medical workers in recognizing depression and anxiety in nonpsychiatric departments. 30762438 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 Biomarker disease BEFREE FMR1 gene polymorphisms, dopaminergic (DAT, DRD, COMT), serotonin (5-HTTLPR, HTR1A, HTR2A), interleukins, MCR1, HCN (potassium channel), neurorregulinas, GABAergic (GABA, GAD, DBI) DBI, GABA (Gabra) receptors and GAD genes (GAD1, GAD2) appear to contribute to generate condition of depression or anxiety like. 25106036 2014
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 Biomarker disease BEFREE <b>Results:</b> The study indicated that past-year Wave II financial mistreatment was associated with significantly increased likelihood of depression, PTSD, GAD, and poor self-rated health; and financial mistreatment perpetrated by family members was associated with particularly increased risk of depression. 29665715 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 AlteredExpression disease BEFREE Patients with PNES had higher self-reported anxiety and depression levels (GAD-7: p = 0.04, PHQ-9: p < 0.01; BDI-II: p < 0.01) but similar QOL to PWE (p = 0.78). 31759316 2020
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 GeneticVariation disease BEFREE In a recent association study in depression, which is highly comorbid with panic disorder, GAD1 risk allele associations were restricted to females. 22662185 2012
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 Biomarker disease BEFREE Item response theory-based linking methods were used to create crosswalk tables that convert scores on the GAD-7 to the TBI-QOL Anxiety metric and scores on the PHQ-9 to the TBI-QOL Depression metric. 31498233 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 AlteredExpression disease BEFREE Whereas cortical GAD67 reduction and subsequent GABA level decrease are consistently observed in schizophrenia and depression, it remains unclear how these GABAergic abnormalities contribute to specific symptoms. 29362511 2018
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 GeneticVariation disease BEFREE Primary outcomes included the Patient Health Questionnaire-9 (PHQ-9) for depression and the Generalized Anxiety Disorder-7 (GAD-7) for anxiety. 28057609 2017
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 Biomarker disease BEFREE The response rate, as measured by a 50% decrease in scores, for those with initial scores ≥10 was 58.6% for depression (PHQ-9) and 50% for anxiety (GAD-7). 28165775 2017
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 GeneticVariation disease BEFREE Furthermore, self-rating questionnaires were used to assess somatic symptom severity (PHQ-15), depression severity (PHQ-9) and anxiety severity (GAD-7). 28554368 2017
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 GeneticVariation disease BEFREE In the third trimester, a second FOBS score, and saliva sample were collected, and the Personal Health Questionnaire-9 (PHQ-9) and General Anxiety Disorder-7 (GAD-7) were administered to measure depression and anxiety respectively. 31306998 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.400 GeneticVariation disease BEFREE Meditation was associated with subjective benefits but no statistically significant effect on depression scores (change in PHQ-9, -3.0±3.9 in the intervention group versus -2.0±4.7 in controls; <i>P</i>=0.45) or anxiety scores (change in GAD-7, -0.9±4.6 versus -0.8±4.8; <i>P</i>=0.91). 29025788 2017