GAD1, glutamate decarboxylase 1, 2571

N. diseases: 245; N. variants: 14
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0014544
Disease: Epilepsy
Epilepsy
0.100 Biomarker disease BEFREE Cells expressing atlastin-1 coexpressed the inhibitory synaptic marker GAD67 in the temporal cortex and hippocampus of patients with epilepsy and an epileptic mouse model. 31729196 2020
CUI: C0014544
Disease: Epilepsy
Epilepsy
0.100 GeneticVariation disease BEFREE In this prospective observational study, 200 patients admitted to two level 4 EMUs completed standardized surveys including the Quality of Life in Epilepsy (QOLIE-31-P), Generalized Anxiety Disorder 7-item (GAD-7), Patient Health Questionnaire (PHQ-9), and Beck Depression Inventory-II (BDI-II). 31759316 2020
CUI: C0014544
Disease: Epilepsy
Epilepsy
0.100 Biomarker disease BEFREE Considering the potential of focal GABAergic neuromodulation in regulating epileptogenesis, the GABA-producing enzyme, γ-aminobutyric acid decarboxylase 67 (GAD67), is highly suitable for epilepsy therapy. 30788386 2019
CUI: C0014544
Disease: Epilepsy
Epilepsy
0.100 Biomarker disease BEFREE The incidence of MRS in patients with epilepsy and GAD-ab was 2 of 22 (9%). 28766694 2018
CUI: C0014544
Disease: Epilepsy
Epilepsy
0.100 GeneticVariation disease BEFREE PWE from rural West China were evaluated for depression and anxiety with the Neurological Disorders Depression Inventory for Epilepsy (C-NDDI-E; Chinese version) and the Generalized Anxiety Disorder-7 (GAD-7; Chinese version). 30125939 2018
CUI: C0014544
Disease: Epilepsy
Epilepsy
0.100 Biomarker disease BEFREE GAD-epilepsy is a rare distinct neurological syndrome with a wide clinical spectrum. 30057567 2018
CUI: C0014544
Disease: Epilepsy
Epilepsy
0.100 Biomarker disease BEFREE The Cleveland Clinic Knowledge Program Data Registry was used to identify adult patients seen in outpatient epilepsy clinic from January to May 2015 and who completed the following scales: ABNAS for subjective cognitive impairment, Patient Health Questionnaire (PHQ-9) for depression, Generalized Anxiety Disorder 7-item (GAD-7) scale, Quality of Life in Epilepsy (QOLIE-10), and EuroQOL five dimensions questionnaire (EQ-5D) for health-related quality of life. 29455082 2018
CUI: C0014544
Disease: Epilepsy
Epilepsy
0.100 Biomarker disease BEFREE The glutamic acid decarboxylase 67 (GAD67) is the major enzyme converting glutamate into GABA and has been implied in a number of neurological disorders such as epilepsy and schizophrenia. 29017573 2017
CUI: C0014544
Disease: Epilepsy
Epilepsy
0.100 Biomarker disease BEFREE In addition, one individual experienced epileptic seizures due to limbic encephalitis (LE) with anti-GAD antibodies. 25036107 2014
CUI: C0014544
Disease: Epilepsy
Epilepsy
0.100 Biomarker disease LHGDN This result is interesting because auto-antibodies to GAD67 and the more widely studied GAD65 homologue encoded by the GAD2 gene, are described in patients with Stiff-Person Syndrome (SPS), epilepsy, cerebellar ataxia and Batten disease. 15571623 2004