Cerebral Palsy, Spastic Quadriplegic, 1
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Homozygosity for a missense mutation in the 67 kDa isoform of glutamate decarboxylase in a family with autosomal recessive spastic cerebral palsy: parallels with Stiff-Person Syndrome and other movement disorders.
|
15571623 |
2004 |
Cerebral Palsy, Spastic Quadriplegic, 1
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Homozygosity for a missense mutation in the 67 kDa isoform of glutamate decarboxylase in a family with autosomal recessive spastic cerebral palsy: parallels with Stiff-Person Syndrome and other movement disorders.
|
15571623 |
2004 |
Cerebral Palsy, Spastic Quadriplegic, 1
|
0.700 |
GeneticVariation
|
disease |
UNIPROT |
Homozygosity for a missense mutation in the 67 kDa isoform of glutamate decarboxylase in a family with autosomal recessive spastic cerebral palsy: parallels with Stiff-Person Syndrome and other movement disorders.
|
15571623 |
2004 |
Cerebral Palsy, Spastic Quadriplegic, 1
|
0.700 |
GermlineCausalMutation
|
disease |
ORPHANET |
Homozygosity for a missense mutation in the 67 kDa isoform of glutamate decarboxylase in a family with autosomal recessive spastic cerebral palsy: parallels with Stiff-Person Syndrome and other movement disorders.
|
15571623 |
2004 |
Cerebral Palsy, Spastic Quadriplegic, 1
|
0.700 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|
Cerebral Palsy, Spastic Quadriplegic, 1
|
0.700 |
Biomarker
|
disease |
CTD_human |
|
|
|
Cerebral Palsy, Spastic Quadriplegic, 1
|
0.700 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Lastly, we examined the associations of the GAD1 gene and BD in two additional independent datasets with a few thousand samples for replication.
|
28710909 |
2017 |
Bipolar Disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Several genes within this GAD1 regulatory network show diagnosis- and sector-specific expression changes within the circuitry of the hippocampus, influencing abnormal GAD1 expression in schizophrenia and bipolar disorder.
|
25738424 |
2015 |
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Several genes within this GAD1 regulatory network show diagnosis- and sector-specific expression changes within the circuitry of the hippocampus, influencing abnormal GAD1 expression in schizophrenia and bipolar disorder.
|
25738424 |
2015 |
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Schizophrenia (SZ) and bipolar disorder (BPD) patients show a downregulation of GAD67, reelin (RELN), brain-derived neurotrophic factor (BDNF), and other genes expressed in telencephalic GABAergic and glutamatergic neurons.
|
25364290 |
2014 |
Bipolar Disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Schizophrenia (SZ) and bipolar disorder (BPD) patients show a downregulation of GAD67, reelin (RELN), brain-derived neurotrophic factor (BDNF), and other genes expressed in telencephalic GABAergic and glutamatergic neurons.
|
25364290 |
2014 |
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The copy number intensities examined using both microarrays and quantitative real-time polymerase chain reaction for the GAD67 gene were significantly decreased in sector CA3/2 of patients with schizophrenia and patients with bipolar disorder.
|
22309971 |
2012 |
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
The copy number intensities examined using both microarrays and quantitative real-time polymerase chain reaction for the GAD67 gene were significantly decreased in sector CA3/2 of patients with schizophrenia and patients with bipolar disorder.
|
22309971 |
2012 |
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
In schizophrenia and bipolar disorder, a network of genes involved in the regulation of GAD₆₇, a marker for the functional differentiation of GABA cells, show pronounced changes in expression and include kainate receptor subunits, TGFβ and Wnt signaling pathways, epigenetic factors and transcription factors.
|
21184762 |
2011 |
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
The nature of these changes is quite different in schizophrenia and bipolar disorder, suggesting that a common cell phenotype (in this case, decreased GAD₆₇ expression) may involve two fundamentally different molecular endophenotypes and reflect unique susceptibility genes involved in the respective disorders.
|
21184762 |
2011 |
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
This molecular remodeling may contribute to the induction of reelin (RELN) and GAD(67) (GAD1) promoter demethylation, and may reverse the downregulation of various GABAergic mRNAs and proteins detected in the telencephalon of patients with schizophrenia or bipolar disorders.
|
22122643 |
2009 |
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
We found that the density of GAD67+ neurons in layers 2-5 of the prefrontal cortex was decreased by 27-36% in both schizophrenia and bipolar disorder.
|
18534564 |
2008 |
Bipolar Disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
This is the first demonstration that there is more DNA fragmentation in cells showing no detectable GAD67 mRNA in patients with bipolar disorder than in schizophrenics or controls.
|
17442540 |
2007 |
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The DNMT1 increase and the GAD67 decrease in BA9 interneurons are significant features of SZ and bipolar disorder with psychosis.
|
15684088 |
2005 |
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
CTD_human |
GABAergic dysfunction in schizophrenia and mood disorders as reflected by decreased levels of glutamic acid decarboxylase 65 and 67 kDa and Reelin proteins in cerebellum.
|
15560956 |
2005 |
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Previous studies suggest linkage between D2S326 near GAD1 and BPAD.
|
15806582 |
2005 |
Bipolar Disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
A research strategy directed toward identifying specific neurochemical markers operative in the etiopathology of psychotic disorders lead to the identification of a downregulation (30-50%) of Reln and glutamic acid decarboxylase 67(GAD67) expression in prefrontal cortex and other brain areas of schizoprenia and bipolar disorder patients with psychosis.
|
11059795 |
2000 |
Major Depressive Disorder
|
0.530 |
AlteredExpression
|
disease |
BEFREE |
This exploratory study provides an initial step for future studies to investigate an association between the reductions in SLC1A2 and GAD1 mRNA expression and their relation to the attenuation of the RAF/MEK/ERK signaling pathway in the dlPFC in MDD.
|
24652383 |
2014 |
Major Depressive Disorder
|
0.530 |
Biomarker
|
disease |
PSYGENET |
This exploratory study provides an initial step for future studies to investigate an association between the reductions in SLC1A2 and GAD1 mRNA expression and their relation to the attenuation of the RAF/MEK/ERK signaling pathway in the dlPFC in MDD.
|
24652383 |
2014 |