GAD2, glutamate decarboxylase 2, 2572

N. diseases: 173; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.070 GeneticVariation disease BEFREE Parental depression and anxiety were screened with the Patient Health Questionnaire-2 (PHQ-2) and Generalized Anxiety Disorder Scale-2 (GAD-2). 31222745 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.070 Biomarker disease BEFREE A random sample of 688 undergraduate university students (mean age = 20.64 ±1.88 years; 53% men) completed a survey composed of a) questions about socio-demographics, academics, lifestyle behaviors, personality type, and smartphone use-related variables; b) 26-item Smartphone Addiction Inventory (SPAI) Scale; and c) brief screeners of depression and anxiety (PHQ-2 and GAD-2), which constitute the two core DSM-IV items for major depressive disorder and generalized anxiety disorder, respectively. 28777828 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.070 Biomarker disease BEFREE FMR1 gene polymorphisms, dopaminergic (DAT, DRD, COMT), serotonin (5-HTTLPR, HTR1A, HTR2A), interleukins, MCR1, HCN (potassium channel), neurorregulinas, GABAergic (GABA, GAD, DBI) DBI, GABA (Gabra) receptors and GAD genes (GAD1, GAD2) appear to contribute to generate condition of depression or anxiety like. 25106036 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.070 Biomarker disease BEFREE Based on the rigorous standard suggested by the Quality Assessment of Diagnostic Accuracy Studies-2, a total of 1,157 participants randomly recruited from the community completed the GAD-7, GAD-2, and other anxiety and depression measures in a counter-balanced order. 30936840 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.070 Biomarker disease BEFREE Patients reported on perceived changes in health outcomes as measured by <i>Short-Form Health Survey</i> (<i>SF-12</i> general, mental, and physical health), <i>Perceived Stress Scale (PSS4)</i>, <i>Work Productivity and Activity Impairment Questionnaire (WPAI)</i>, <i>World Health Organization Well-Being Index (WHO-5</i>), <i>Pain Visual Analog Scale (VAS)</i>, <i>Fatigue Severity Scale (VAS; FSS)</i>, <i>Generalized Anxiety Disorder Scale (GAD2)</i>, <i>Patient Health Questionnaire</i> for depression <i>(PHQ2), Pittsburgh Sleep Quality Index (PSQI)</i> global rating of sleep quality, and the <i>Behavioral Risk Factor Surveillance System (BRFSS</i>; nutrition, exercise, and physical activity). 31346339 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.070 AlteredExpression disease BEFREE There were a significant 58% increase of SCN GAD65/67-ir and a significant 169% increase of SCN GAD67-mRNA in the depression group. 28608287 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.070 GeneticVariation disease BEFREE Based on cut-off-scores of standardized self-report scales (PHQ-9, GAD-2), rates of depression (8.4%; 95%CI 6.90-10.30) and anxiety symptoms (7.8%; 95%CI 6.30-9.60) corresponded to those of participants without cancer. 31443804 2019