Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Insulin-Dependent
0.300 Biomarker disease BEFREE We have developed a transgenic mouse model of Type 1 Diabetes (T1D) in which human GAD65 is expressed in pancreatic β-cells, and human MHC-II is expressed on antigen presenting cells. 30733517 2019
Diabetes Mellitus, Insulin-Dependent
0.300 GeneticVariation disease BEFREE Next-generation targeted sequencing of HLA-DRB1 and HLA-DRB3, -DRB4, and -DRB5 (abbreviated as DRB345) provides high resolution of functional variant positions to investigate their associations with type 1 diabetes risk and with autoantibodies against insulin (IAA), GAD65 (GADA), IA-2 (IA-2A), and ZnT8 (ZnT8A). 31127057 2019
Diabetes Mellitus, Insulin-Dependent
0.300 Biomarker disease BEFREE As linear epitopes are sparsely described for GAD65 in T1D, we aimed to identify and thoroughly characterize two GAD65 antibodies using immunoassays. 31207885 2019
Diabetes Mellitus, Insulin-Dependent
0.300 Biomarker disease BEFREE A membrane-bound enzyme on the pancreatic beta-cells, glutamic acid decarboxylase 65 (GAD65), is one of the main autoantigens in type 1 diabetes. 31009057 2019
Diabetes Mellitus, Insulin-Dependent
0.300 GeneticVariation disease BEFREE A Type 1 Diabetes Genetic Risk Score Can Identify Patients With GAD65 Autoantibody-Positive Type 2 Diabetes Who Rapidly Progress to Insulin Therapy. 30352895 2019
Diabetes Mellitus, Insulin-Dependent
0.300 Biomarker disease BEFREE The GAD65 and IA-2 antibodies (Abs) are biomarkers of the development of type 1 diabetes mellitus (T1DM) in both children and adults. 30727763 2019
Diabetes Mellitus, Insulin-Dependent
0.300 Biomarker disease BEFREE Since GAD65 is intracellularly located and associated with type 1 diabetes mellitus and different clinical neurological phenotypes such as CA, stiff-person syndrome, and epilepsy, some researchers have argued that anti-GAD65 Abs have no pathogenic roles. 30343467 2019
Diabetes Mellitus, Insulin-Dependent
0.300 Biomarker disease BEFREE The presence of IA-2var-specific AAb in relatives was associated with accelerated progression to T1D in those positive for AAb to GAD65 and/or insulin but negative in the standard test for IA-2 AAb. 31167877 2019
Diabetes Mellitus, Insulin-Dependent
0.300 Biomarker disease BEFREE HLA-DR3-DQ2<sup>+</sup>huCD4<sup>+</sup>IA/IE<sup>-/-</sup>RIP.B7.1<sup>+</sup> mice spontaneously developed autoimmune diabetes (incidence 46% by 35 weeks of age), accompanied by numerous hallmarks of human type 1 diabetes (autoantibodies against GAD65 and proinsulin; pancreatic islet infiltration by CD4<sup>+</sup>, CD8<sup>+</sup> B220<sup>+</sup>, CD11b<sup>+</sup> and CD11c<sup>+</sup> immune cells). 31612266 2019
Diabetes Mellitus, Insulin-Dependent
0.300 Biomarker disease BEFREE The N-terminal truncated GAD65 isoform was significantly less recognized in GAD65Ab-positive people with stiff-person syndrome (P=0.002) and in healthy individuals (P=0.0001) than in people with Type 1 diabetes. 30264481 2019
Diabetes Mellitus, Insulin-Dependent
0.300 Biomarker disease BEFREE For the subjects diagnosed as T1D, mean C-peptide was 0.63 ± 0.51 nmol/L (1.91 ± 1.53 ng/mL), with 16 (16.2%) IA2 positive, 53 (53.5%) GAD-65 positive, and 10 (10.1%) positive for both autoantibodies. 30710658 2019
Diabetes Mellitus, Insulin-Dependent
0.300 Biomarker disease BEFREE Patients with ECL-GAD65 antibody-negative share a similar phenotype with type 2 diabetes mellitus patients, whereas patients with ECL-GAD65 antibody-positive resemble those with type 1 diabetes mellitus. 31769235 2019
Diabetes Mellitus, Insulin-Dependent
0.300 Biomarker disease BEFREE Furthermore, donor islet exosome cargo analysis showed time-specific increase in islet autoantigen, glutamic acid decarboxylase 65 (GAD65), implicated in T1D autoimmunity. 30801971 2019
Diabetes Mellitus, Insulin-Dependent
0.300 Biomarker disease BEFREE Among patients with ketosis-prone diabetes (KPD), characterized by presentation with diabetic ketoacidosis (DKA), >60% of adults lack three classic islet autoantibodies-IA-2, GAD65, and ZnT8 Abs-associated with type 1 diabetes. 30327357 2018
Diabetes Mellitus, Insulin-Dependent
0.300 GeneticVariation disease BEFREE β-cell autoantibodies against insulin (IAA), GAD65 (GADA) and IA-2 (IA-2A) precede onset of childhood type 1 diabetes (T1D). 28941965 2018
Diabetes Mellitus, Insulin-Dependent
0.300 Biomarker disease BEFREE GAD65 autoantibody characteristics in patients with co-occurring type 1 diabetes and epilepsy may help identify underlying epilepsy etiologies. 29636076 2018
Diabetes Mellitus, Insulin-Dependent
0.300 Biomarker disease BEFREE In this study, we examined the frequency of circulating CD4+CXCR5+ and CD4+CXCR5+ICOS+ (representing Tfh) cells as well as serum levels of anti-glutamic acid decarboxylase 65 (GAD65) and islet cell autoantibodies (ICA) in children with type I diabetes. 30644700 2018
Diabetes Mellitus, Insulin-Dependent
0.300 Biomarker disease BEFREE Here we show that autoreactive CD8<sup>+</sup> Tscm specific for β-cell antigens GAD65, insulin, and IGRP are present in patients with type 1 diabetes (T1D). 29506985 2018
Diabetes Mellitus, Insulin-Dependent
0.300 Biomarker disease BEFREE Additionally, human islet EVs induce an increase in antibodies against glutamic acid decarboxylase 65 (GAD65) in T1D PBMCs. 30307543 2018
Diabetes Mellitus, Insulin-Dependent
0.300 Biomarker disease BEFREE We present here the correlation of picomolar affinities between surface-plasmon and electrochemical immunoassays for the binding of serum glutamic acid decarboxylase 65 autoantibody (GADA), a biomarker of type 1 diabetes (T1D), to its antigen GAD-65. 30213185 2018
Diabetes Mellitus, Insulin-Dependent
0.300 Biomarker disease BEFREE Notably, logistic regression analysis suggested that DQ8/8 patients had an increased risk to be diagnosed with tGADA (<i>P</i> = 0.003) compared with fGADA (<i>P</i> = 0.09). tGADA had a higher diagnostic sensitivity for type 1 diabetes than both fGADA and RSRGADA. 28028075 2017
Diabetes Mellitus, Insulin-Dependent
0.300 Biomarker disease BEFREE Type 1 diabetes autoantibodies (GAD65, Islet, and ZincT8) and monogenic diabetes genetic tests were negative. 27807935 2017
Diabetes Mellitus, Insulin-Dependent
0.300 AlteredExpression disease BEFREE Autoimmune or type 1 diabetes mellitus was ruled out with normal levels of anti-glutamic acid decarboxylase 65 (GAD65) antibody, zinc transporter 8 (ZnT8) antibody, and islet antigen-2 (IA-2) antibody. 29254501 2017
Diabetes Mellitus, Insulin-Dependent
0.300 Biomarker disease BEFREE Accordingly, the anchoring of GAD65 to exosome-mimetic liposomes strongly boosted antigen presentation and T-cell activation in the context of the human T1D susceptibility haplotype HLA-DR4. 27872147 2017
Diabetes Mellitus, Insulin-Dependent
0.300 Biomarker disease BEFREE It seems probable that treatment with GAD65-alum 20 µg sc can preserve residual beta cell function in T1D, but efficacy needs to be improved. 28480759 2017