GAD2, glutamate decarboxylase 2, 2572

N. diseases: 173; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.330 GeneticVariation disease BEFREE The best cut-off points to obtain high sensitivity values was 3, on both the PHQ-2 (major depressive disorder) and the GAD-2 (generalized anxiety disorder). 29549826 2018
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.330 AlteredExpression disease BEFREE In addition, using quantitative RT-PCR, expression of GAD2 full length and truncated transcripts were measured in the DLPFC of patients with schizophrenia, bipolar disorder and major depression. 26848839 2016
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.330 Biomarker disease BEFREE We used real-time quantitative polymerase chain reaction (qPCR) to assess expression levels of two GABA synthesizing enzymes (glutamate decarboxylase; GAD65 and GAD67) and of three markers of GABA neuron subpopulations (PV, CR, SST) in the dorsolateral prefrontal cortex (DLPFC; Brodmann area 9) in triads (n=19) of control subjects and matched subjects with BPD or MDD. 21226980 2011
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.330 Biomarker disease CTD_human GABAergic dysfunction in schizophrenia and mood disorders as reflected by decreased levels of glutamic acid decarboxylase 65 and 67 kDa and Reelin proteins in cerebellum. 15560956 2005