GAD2, glutamate decarboxylase 2, 2572

N. diseases: 173; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.380 Biomarker disease BEFREE Meta-analysis established that the pooled prevalence of GAD65 autoantibodies was 5.8% (95% confidence interval [CI]: 2.0-15.6%; I<sup>2</sup>  = 91%; nine studies) in psychotic disorders, with a prevalence of 4.6% (95%CI: 1.2-15.9%; nine studies; I<sup>2</sup>  = 89%) and 6.2% (95%CI: 1.2-27.0%; two studies; I<sup>2</sup>  = 69%) in schizophrenia and bipolar disorder, respectively. 28573688 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.380 AlteredExpression disease BEFREE Several of the genes in this network including epigenetic factors histone deacetylase 1 (HDAC1) and death-associated protein 6 (DAXX), the GABAergic enzyme GAD65 as well as the kainate receptor (KAR) subunits GluR6 and 7 show significant changes in expression in this area in SZ. 27733539 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.380 AlteredExpression disease BEFREE Moreover, the patients with schizophrenia with completed suicide or positive nicotine exposure showed significantly higher expression of GAD2 full length transcript. 26848839 2016
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.380 AlteredExpression disease BEFREE In concert with previous studies, these findings suggest that schizoaffective disorder is associated with lower levels of both GAD65 and GAD67 mRNA and protein in the PFC, whereas subjects with schizophrenia have lower mean levels of only GAD67 mRNA and protein. 24993056 2015
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.380 Biomarker disease BEFREE We used dual-label in situ hybridization to quantify GABA(A) α1 subunit mRNA expression in calcium/calmodulin-dependent kinase II α (CaMKIIα)-containing pyramidal cells and glutamic acid decarboxylase 65 kDa (GAD65)-containing interneurons in layer 3 of the PFC from matched schizophrenia and healthy comparison subjects. 21677653 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.380 Biomarker disease BEFREE These results suggest that GAD2 and GLUL do not play a major role in schizophrenia pathogenesis and there is no gene-gene interaction between the eight genes in the Japanese population. 19125103 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.380 Biomarker disease CTD_human Schizophrenia subjects showed significant decreases in mRNA levels of GAD(67), GAD(65), GAT-1, mGluR2, and neuronal nitric oxide synthase. 18923069 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.380 GeneticVariation disease BEFREE Using the multifactor-dimensionality reduction method (MDR), we found that the interactions among the rs187269C/T polymorphism in the GABRB2 gene, the -243A/G polymorphism in the GAD2 gene and the 27379C/T and 661C/T polymorphisms in the GAD1 gene revealed a significant association with schizophrenia (P<0.001). 17412563 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.380 GeneticVariation disease LHGDN Using the multifactor-dimensionality reduction method (MDR), we found that the interactions among the rs187269C/T polymorphism in the GABRB2 gene, the -243A/G polymorphism in the GAD2 gene and the 27379C/T and 661C/T polymorphisms in the GAD1 gene revealed a significant association with schizophrenia (P<0.001). 17412563 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.380 Biomarker disease CTD_human This study demonstrates for the first time significant deficits in GABAergic markers Reelin and GAD 65 and 67 proteins in bipolar subjects and global deficits in the latter proteins in schizophrenia and mood disorders, accounting for the reported alterations in CSF/plasma levels of glutamate and GABA in these disorders. 15560956 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.380 AlteredExpression disease BEFREE Although the levels of GAD65 and GAD67 messages were increased in schizophrenia subjects, the proportion of the two GAD isoforms remained constant in controls and schizophrenics. 15114630 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.380 AlteredExpression disease LHGDN Although the levels of GAD65 and GAD67 messages were increased in schizophrenia subjects, the proportion of the two GAD isoforms remained constant in controls and schizophrenics. 15114630 2004
CUI: C0036572
Disease: Seizures
Seizures
0.340 Biomarker phenotype BEFREE Enhanced susceptibility to stress and seizures in GAD65 deficient mice. 29377906 2018
CUI: C0036572
Disease: Seizures
Seizures
0.340 Biomarker phenotype BEFREE Three of the seven patients with LE with different antibodies (NMDAR: n=1, Ma-2/Ta: n=1 and GAD65: n=1) achieved persistent seizure freedom along with no accelerated memory decline after surgery. 29253681 2018
CUI: C0036572
Disease: Seizures
Seizures
0.340 Biomarker phenotype BEFREE In contrast patients with seizures related to GAD65-antibodies (an intracellular antigen) frequently develop epilepsy and have suboptimal response to treatment (including surgery). 28234800 2017
CUI: C0036572
Disease: Seizures
Seizures
0.340 GeneticVariation phenotype BEFREE Using both a tagging and functional single nucleotide polymorphism (SNP) approach, we genotyped the GAD1 and GAD2 genes and linked them with PTS data, regarding time to first seizure, obtained for 257 adult subjects with severe TBI. 22840783 2013
CUI: C0036572
Disease: Seizures
Seizures
0.340 Biomarker phenotype CTD_human Mice lacking the 65 kDa isoform of glutamic acid decarboxylase (GAD65) maintain normal levels of GAD67 and GABA in their brains but are susceptible to seizures. 8954991 1996
CUI: C0036572
Disease: Seizures
Seizures
0.340 Biomarker phenotype CTD_human Labeling for GAD65 mRNA and associated protein is substantially increased in the remaining GABA neurons at 2-4 months after the initial seizure episode. 8985701 1996
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.330 GeneticVariation disease BEFREE The best cut-off points to obtain high sensitivity values was 3, on both the PHQ-2 (major depressive disorder) and the GAD-2 (generalized anxiety disorder). 29549826 2018
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.330 AlteredExpression disease BEFREE In addition, using quantitative RT-PCR, expression of GAD2 full length and truncated transcripts were measured in the DLPFC of patients with schizophrenia, bipolar disorder and major depression. 26848839 2016
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.330 Biomarker disease BEFREE We used real-time quantitative polymerase chain reaction (qPCR) to assess expression levels of two GABA synthesizing enzymes (glutamate decarboxylase; GAD65 and GAD67) and of three markers of GABA neuron subpopulations (PV, CR, SST) in the dorsolateral prefrontal cortex (DLPFC; Brodmann area 9) in triads (n=19) of control subjects and matched subjects with BPD or MDD. 21226980 2011
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.330 Biomarker disease BEFREE There are two isoforms of GAD, GAD1 and GAD2, which were reported to be associated with AD in males of Han Taiwanese (GAD1) and Russian (GAD2) ancestry. 19111404 2009
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.330 Biomarker disease BEFREE Analyses in these populations did not support a role for GAD2 in alcoholism. 17034009 2007
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.330 GeneticVariation disease BEFREE Three valid SNPs at the GAD2 gene demonstrated no associations with alcoholism. 17067345 2006
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.330 Biomarker disease CTD_human GABAergic dysfunction in schizophrenia and mood disorders as reflected by decreased levels of glutamic acid decarboxylase 65 and 67 kDa and Reelin proteins in cerebellum. 15560956 2005