Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Thus, TAB-3-GSH is a promising probe for tumor targeting in vivo.
|
31319323 |
2019 |
Clostridium; difficile (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Hypervirulent Strain of Clostridium Difficile: NAP1/B1/027 - A Brief Overview.
|
30967977 |
2019 |
Arthritis, Psoriatic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, in unstimulated PBMCs, TAB3 expression was significantly downregulated in PA patients compared to atopic non-PA individuals.
|
30893695 |
2019 |
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Mechanistic studies further reveal that the binding of NAP1 to the cellular chaperone heat shock protein 90 (HSP90) is required for its protein stabilization, and NAP1 plays an essential role in HSP90-mediated invasion and metastasis by provoking MMP9 activation and the epithelial-to-mesenchymal transition in NSCLC cells.
|
30867003 |
2019 |
Non-Small Cell Lung Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Nck-associated protein 1 (NAP1/NCKAP1) is highly expressed in primary non-small-cell lung cancer (NSCLC) when compared with adjacent normal lung tissues, and its expression levels are strongly associated with the histologic tumor grade, metastasis and poor survival rate of NSCLC patients.
|
30867003 |
2019 |
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Our insights demonstrate the importance and functional regulation of the HSP90-NAP1 protein complex in cancer metastatic signaling, which spur new avenues to target this interaction as a novel approach to block NSCLC metastasis.
|
30867003 |
2019 |
Disseminated Malignant Neoplasm
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Our insights demonstrate the importance and functional regulation of the HSP90-NAP1 protein complex in cancer metastatic signaling, which spur new avenues to target this interaction as a novel approach to block NSCLC metastasis.
|
30867003 |
2019 |
Idiopathic Pulmonary Fibrosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The decreased expression of miR‑30a in the BALF of patients with IPF, along with the consequential increase in TAB3 expression, may be a crucial factor in IPF progression.
|
30365083 |
2018 |
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, knockdown of TAB3 by small interfering RNA inhibited the proliferation of ESCC cells, and reduced the migration and invasion of ESCC cells.
|
30226617 |
2018 |
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
The NF‑κB pathway serves important roles in tumor cell proliferation and migration; however, the clinical relevance of TAB3 and its biological function in ESCC progression remain elusive.
|
30226617 |
2018 |
Squamous cell carcinoma of esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, these results demonstrated that TAB3 may be a promising therapeutic target for the treatment of ESCC.
|
30226617 |
2018 |
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results demonstrated that TAB3 expression was significantly increased in human ESCC cell lines and tissue samples, and the expression of TAB3 was associated with ESCC lymph node metastasis, T stage, pathological grade and Ki‑67 expression in 80 ESCC samples, as determined by immunohistochemistry.
|
30226617 |
2018 |
Central Diabetes Insipidus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Whole genome sequencing of CA-CDI isolates confirmed that NAP 1-like pulsotypes are commonplace in CA-CDI.
|
30170546 |
2018 |
Clostridium difficile infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Clostridium difficile infection (CDI) is an increasing cause of nosocomial diarrhoea worldwide, which has been partly attributed to the emergence of hypervirulent strains including C. difficile BI/NAP1/ribotype 027 and BK/NAP7/ribotype 078.
|
30052178 |
2018 |
Central Diabetes Insipidus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Clostridium difficile infection (CDI) is an increasing cause of nosocomial diarrhoea worldwide, which has been partly attributed to the emergence of hypervirulent strains including C. difficile BI/NAP1/ribotype 027 and BK/NAP7/ribotype 078.
|
30052178 |
2018 |
Clostridium difficile infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Clostridium difficile infections (CDI), particularly those caused by the BI/NAP1/027 epidemic strains, are challenging to treat.
|
30004695 |
2018 |
Clostridium; difficile (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Diversity of multidrug-resistant epidemic Clostridium difficile NAP1/RT027/ST01 strains in tertiary hospitals from Honduras.
|
29890209 |
2018 |
Central Diabetes Insipidus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Colonized patients contribute to transmission, but CDI cases are more likely linked to other infected patients than colonized patients in this cohort with high rates of the NAP1/027/ST1 strain, highlighting the importance of local prevalence of virulent strains in determining transmission dynamics.
|
29846557 |
2019 |
Clostridium; difficile (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Poor yield of Clostridium difficile testing algorithms using glutamate dehydrogenase antigen and C. difficile toxin enzyme immunoassays in a pediatric population with declining prevalence of clostridium difficile strain BI/NAP1/027.
|
29567127 |
2018 |
Tumor Cell Invasion
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
In addition, TAB3 knockdown decreased Survivin expression and suppressed colorectal cancer cell migration and invasion <i>in vitro</i>, and reduced liver metastasis <i>in vivo</i>.
|
29290971 |
2017 |
Neoplasm Metastasis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
In this study, we demonstrated that TAB3 is upregulated in colorectal cancer tissues and that high TAB3 levels correlated with tumor metastasis and a poor prognosis in colorectal cancer.
|
29290971 |
2017 |
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings suggest TAB3 may be a useful prognostic biomarker in colorectal cancer and a target for treatment of metastatic colorectal cancer.
|
29290971 |
2017 |
Secondary malignant neoplasm of liver
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, TAB3 knockdown decreased Survivin expression and suppressed colorectal cancer cell migration and invasion <i>in vitro</i>, and reduced liver metastasis <i>in vivo</i>.
|
29290971 |
2017 |
Secondary Neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
In this study, we demonstrated that TAB3 is upregulated in colorectal cancer tissues and that high TAB3 levels correlated with tumor metastasis and a poor prognosis in colorectal cancer.
|
29290971 |
2017 |
Secondary malignant neoplasm of colon and/or rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings suggest TAB3 may be a useful prognostic biomarker in colorectal cancer and a target for treatment of metastatic colorectal cancer.
|
29290971 |
2017 |