Central Diabetes Insipidus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Colonized patients contribute to transmission, but CDI cases are more likely linked to other infected patients than colonized patients in this cohort with high rates of the NAP1/027/ST1 strain, highlighting the importance of local prevalence of virulent strains in determining transmission dynamics.
|
29846557 |
2019 |
Clostridium; difficile (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Hypervirulent Strain of Clostridium Difficile: NAP1/B1/027 - A Brief Overview.
|
30967977 |
2019 |
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Mechanistic studies further reveal that the binding of NAP1 to the cellular chaperone heat shock protein 90 (HSP90) is required for its protein stabilization, and NAP1 plays an essential role in HSP90-mediated invasion and metastasis by provoking MMP9 activation and the epithelial-to-mesenchymal transition in NSCLC cells.
|
30867003 |
2019 |
Non-Small Cell Lung Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Nck-associated protein 1 (NAP1/NCKAP1) is highly expressed in primary non-small-cell lung cancer (NSCLC) when compared with adjacent normal lung tissues, and its expression levels are strongly associated with the histologic tumor grade, metastasis and poor survival rate of NSCLC patients.
|
30867003 |
2019 |
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Our insights demonstrate the importance and functional regulation of the HSP90-NAP1 protein complex in cancer metastatic signaling, which spur new avenues to target this interaction as a novel approach to block NSCLC metastasis.
|
30867003 |
2019 |
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Thus, TAB-3-GSH is a promising probe for tumor targeting in vivo.
|
31319323 |
2019 |
Arthritis, Psoriatic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, in unstimulated PBMCs, TAB3 expression was significantly downregulated in PA patients compared to atopic non-PA individuals.
|
30893695 |
2019 |
Disseminated Malignant Neoplasm
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Our insights demonstrate the importance and functional regulation of the HSP90-NAP1 protein complex in cancer metastatic signaling, which spur new avenues to target this interaction as a novel approach to block NSCLC metastasis.
|
30867003 |
2019 |
Clostridium difficile infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Clostridium difficile infection (CDI) is an increasing cause of nosocomial diarrhoea worldwide, which has been partly attributed to the emergence of hypervirulent strains including C. difficile BI/NAP1/ribotype 027 and BK/NAP7/ribotype 078.
|
30052178 |
2018 |
Clostridium difficile infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Clostridium difficile infections (CDI), particularly those caused by the BI/NAP1/027 epidemic strains, are challenging to treat.
|
30004695 |
2018 |
Clostridium difficile infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The increased incidence and severity of Clostridium difficile infection (CDI) are thought to result partly from the emergence of the hypervirulent BI/NAP1/027 strain.
|
29174729 |
2018 |
Central Diabetes Insipidus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The increased incidence and severity of Clostridium difficile infection (CDI) are thought to result partly from the emergence of the hypervirulent BI/NAP1/027 strain.
|
29174729 |
2018 |
Central Diabetes Insipidus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Clostridium difficile infection (CDI) is an increasing cause of nosocomial diarrhoea worldwide, which has been partly attributed to the emergence of hypervirulent strains including C. difficile BI/NAP1/ribotype 027 and BK/NAP7/ribotype 078.
|
30052178 |
2018 |
Central Diabetes Insipidus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Whole genome sequencing of CA-CDI isolates confirmed that NAP 1-like pulsotypes are commonplace in CA-CDI.
|
30170546 |
2018 |
Clostridium; difficile (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Diversity of multidrug-resistant epidemic Clostridium difficile NAP1/RT027/ST01 strains in tertiary hospitals from Honduras.
|
29890209 |
2018 |
Clostridium; difficile (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Poor yield of Clostridium difficile testing algorithms using glutamate dehydrogenase antigen and C. difficile toxin enzyme immunoassays in a pediatric population with declining prevalence of clostridium difficile strain BI/NAP1/027.
|
29567127 |
2018 |
Clostridium; difficile (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Prevalence of the Clostridium difficile BI/NAP1/027 strain across the United States Veterans Health Administration.
|
29174729 |
2018 |
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, knockdown of TAB3 by small interfering RNA inhibited the proliferation of ESCC cells, and reduced the migration and invasion of ESCC cells.
|
30226617 |
2018 |
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
The NF‑κB pathway serves important roles in tumor cell proliferation and migration; however, the clinical relevance of TAB3 and its biological function in ESCC progression remain elusive.
|
30226617 |
2018 |
Squamous cell carcinoma of esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, these results demonstrated that TAB3 may be a promising therapeutic target for the treatment of ESCC.
|
30226617 |
2018 |
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results demonstrated that TAB3 expression was significantly increased in human ESCC cell lines and tissue samples, and the expression of TAB3 was associated with ESCC lymph node metastasis, T stage, pathological grade and Ki‑67 expression in 80 ESCC samples, as determined by immunohistochemistry.
|
30226617 |
2018 |
Idiopathic Pulmonary Fibrosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The decreased expression of miR‑30a in the BALF of patients with IPF, along with the consequential increase in TAB3 expression, may be a crucial factor in IPF progression.
|
30365083 |
2018 |
Clostridium difficile infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
An outbreak of Clostridium difficile infection (CDI) caused by ribotype 027 (B1/NAP1) began in our hospital in November 2014, and produced 141 episodes in the following months.
|
28501926 |
2017 |
Clostridium difficile infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Impact of the NAP-1 strain on disease severity, mortality, and recurrence of healthcare-associated Clostridium difficile infection.
|
28645479 |
2017 |
Central Diabetes Insipidus
|
0.100 |
Biomarker
|
disease |
BEFREE |
An outbreak of Clostridium difficile infection (CDI) caused by ribotype 027 (B1/NAP1) began in our hospital in November 2014, and produced 141 episodes in the following months.
|
28501926 |
2017 |