|
Central Diabetes Insipidus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Whole genome sequencing of CA-CDI isolates confirmed that NAP 1-like pulsotypes are commonplace in CA-CDI.
|
30170546 |
2018 |
|
Thiel-Behnke corneal dystrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
We demonstrate, using the Syrian golden hamster model of CDI, that the inclusion of binary toxin components CDTa and CDTb significantly improves the efficacy of the vaccine against challenge with NAP1 strains in comparison to vaccines containing only TcdA and TcdB antigens, while providing comparable efficacy against challenge with the prototypic, non-epidemic strain VPI10463.
|
28125650 |
2017 |
|
Central Diabetes Insipidus
|
0.100 |
Biomarker
|
disease |
BEFREE |
We compared multilocus variable-number tandem-repeat analysis (MLVA) and macrorestriction endonuclease analysis using pulsed-field gel electrophoresis (PFGE) to determine their utility to identify clusters of Clostridium difficile infection (CDI) among 91 isolates of PCR ribotype 027 (NAP1, for North American pulsed-field type 1) from nine hospitals (and 10 general practitioners associated with one institution) in England.
|
18216211 |
2008 |
|
Clostridium difficile infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
We compared multilocus variable-number tandem-repeat analysis (MLVA) and macrorestriction endonuclease analysis using pulsed-field gel electrophoresis (PFGE) to determine their utility to identify clusters of Clostridium difficile infection (CDI) among 91 isolates of PCR ribotype 027 (NAP1, for North American pulsed-field type 1) from nine hospitals (and 10 general practitioners associated with one institution) in England.
|
18216211 |
2008 |
|
Liver carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Using the GSE54751 database we evaluated expression from 10 HCC samples, which strongly suggested downregulation of miR-342-3p and we also found inverse expression between miR-342-3p and its targets IKK-γ, TAB2 and TAB3 from 71 HCC samples.
|
25580008 |
2015 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Transforming growth factor β-activated protein kinase 1 (TAK1)-binding protein 3 (TAB3) was initially characterized as an adapter protein essential for TAK1 activation in response to IL-1β or TNFα, however, the physiological role of TAB3 in ovarian cancer tumorigenesis is still not fully understood.
|
27651027 |
2016 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Thus, TAB-3-GSH is a promising probe for tumor targeting in vivo.
|
31319323 |
2019 |
|
Malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that TAB3 plays a critical role in NSCLC progression and chemoresistance and that TAB3 depletion may be a promising approach to lung cancer therapy.
|
26476534 |
2016 |
|
Carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that TAB3 plays a critical role in NSCLC progression and chemoresistance and that TAB3 depletion may be a promising approach to lung cancer therapy.
|
26476534 |
2016 |
|
Primary malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that TAB3 plays a critical role in NSCLC progression and chemoresistance and that TAB3 depletion may be a promising approach to lung cancer therapy.
|
26476534 |
2016 |
|
Non-Small Cell Lung Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
These results suggest that TAB3 plays a critical role in NSCLC progression and chemoresistance and that TAB3 depletion may be a promising approach to lung cancer therapy.
|
26476534 |
2016 |
|
Secondary malignant neoplasm of colon and/or rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings suggest TAB3 may be a useful prognostic biomarker in colorectal cancer and a target for treatment of metastatic colorectal cancer.
|
29290971 |
2017 |
|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings suggest TAB3 may be a useful prognostic biomarker in colorectal cancer and a target for treatment of metastatic colorectal cancer.
|
29290971 |
2017 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings suggest TAB3 may be a useful prognostic biomarker in colorectal cancer and a target for treatment of metastatic colorectal cancer.
|
29290971 |
2017 |
|
Liver carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
The transforming growth factor β-activated kinase-binding protein 3 (TAB3) plays a crucial role in modulating cell apoptosis and proliferation in many diseases, including hepatocellular carcinoma, lung cancer, and intracerebral hemorrhage.
|
28462515 |
2017 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results demonstrated that TAB3 expression was significantly increased in human ESCC cell lines and tissue samples, and the expression of TAB3 was associated with ESCC lymph node metastasis, T stage, pathological grade and Ki‑67 expression in 80 ESCC samples, as determined by immunohistochemistry.
|
30226617 |
2018 |
|
Clostridium; difficile (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
The rapid spread of Clostridium difficile NAP1/BI/027 (C. difficile 027) has become one of the leading threats of healthcare-associated infections worldwide.
|
27411304 |
2016 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
The NF‑κB pathway serves important roles in tumor cell proliferation and migration; however, the clinical relevance of TAB3 and its biological function in ESCC progression remain elusive.
|
30226617 |
2018 |
|
Central Diabetes Insipidus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The increased incidence and severity of Clostridium difficile infection (CDI) are thought to result partly from the emergence of the hypervirulent BI/NAP1/027 strain.
|
29174729 |
2018 |
|
Clostridium difficile infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The increased incidence and severity of Clostridium difficile infection (CDI) are thought to result partly from the emergence of the hypervirulent BI/NAP1/027 strain.
|
29174729 |
2018 |
|
Clostridium; difficile (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Hypervirulent Strain of Clostridium Difficile: NAP1/B1/027 - A Brief Overview.
|
30967977 |
2019 |
|
Central Diabetes Insipidus
|
0.100 |
Biomarker
|
disease |
BEFREE |
The gold standard was the toxigenic culture for the diagnosis of CDI and PCR ribotyping for the identification of the NAP1/027/BI strain.
|
21487764 |
2011 |
|
Diarrhea
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
The dominant 072 ribotype was carried by 43% (12/28) of subjects, while the hypervirulent strain R027 (B1/NAP1/027) was isolated from 3 subjects (11%), 2 of whom displayed C. difficile associated diarrhea (CDAD) symptoms at the time of sampling.
|
22162545 |
2012 |
|
Idiopathic Pulmonary Fibrosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The decreased expression of miR‑30a in the BALF of patients with IPF, along with the consequential increase in TAB3 expression, may be a crucial factor in IPF progression.
|
30365083 |
2018 |
|
Central Diabetes Insipidus
|
0.100 |
Biomarker
|
disease |
BEFREE |
The BI/NAP1/027 strain caused CDI in only 1 patient.
|
25782900 |
2015 |