Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.010 AlteredExpression disease BEFREE In this case, local pharmacologic down-regulation of NAP-1/IL-8 activity could be a promising therapeutic strategy in PS. 1711550 1991
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.020 Biomarker disease BEFREE Based on these results, the possible role of human Nap1 in AD is discussed. 10673335 2000
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.020 AlteredExpression disease BEFREE In addition, hNap1BP bound to the SH3 domain of c-Abl and Nck. hNap1BP is expressed ubiquitously in various tissues like human Nap1, and intriguingly these genes are co-expressed in hippocampus and cerebral cortex in mouse brain where AD pathological features are strongly evident. 11418237 2001
CUI: C0085682
Disease: Hypophosphatemia
Hypophosphatemia 		0.010 AlteredExpression phenotype BEFREE It is characterized by renal phosphate wasting, leading to hypophosphatemia and an inappropriately normal or low serum level of 1,25(OH)2 vitamin D. Previous studies have pointed to a circulating factor or phosphatonin-inhibiting phosphate transport by decreasing mRNA of the proximal tubule NaP(i) cotransporter NaPi-2A. 15454393 2005
CUI: C1411966
Disease: Clostridium; difficile (disorder)
Clostridium; difficile (disorder) 		0.100 Biomarker disease BEFREE Severe Clostridium difficile associated disease is associated with outbreaks of the recently described BI/NAP1 epidemic clone. 17035492 2007
CUI: C0343386
Disease: Clostridium difficile infection
Clostridium difficile infection 		0.100 GeneticVariation disease BEFREE Clostridium difficile infections in a Canadian tertiary care hospital before and during a regional epidemic associated with the BI/NAP1/027 strain. 18573937 2008
CUI: C0343386
Disease: Clostridium difficile infection
Clostridium difficile infection 		0.100 Biomarker disease BEFREE We compared multilocus variable-number tandem-repeat analysis (MLVA) and macrorestriction endonuclease analysis using pulsed-field gel electrophoresis (PFGE) to determine their utility to identify clusters of Clostridium difficile infection (CDI) among 91 isolates of PCR ribotype 027 (NAP1, for North American pulsed-field type 1) from nine hospitals (and 10 general practitioners associated with one institution) in England. 18216211 2008
CUI: C0687720
Disease: Central Diabetes Insipidus
Central Diabetes Insipidus 		0.100 Biomarker disease BEFREE We compared multilocus variable-number tandem-repeat analysis (MLVA) and macrorestriction endonuclease analysis using pulsed-field gel electrophoresis (PFGE) to determine their utility to identify clusters of Clostridium difficile infection (CDI) among 91 isolates of PCR ribotype 027 (NAP1, for North American pulsed-field type 1) from nine hospitals (and 10 general practitioners associated with one institution) in England. 18216211 2008
CUI: C0687720
Disease: Central Diabetes Insipidus
Central Diabetes Insipidus 		0.100 Biomarker disease BEFREE Infection with the epidemic NAP-1 strain was not associated with metronidazole failure in endemic CDI. 19081526 2008
CUI: C0343386
Disease: Clostridium difficile infection
Clostridium difficile infection 		0.100 GeneticVariation disease BEFREE Clostridium difficile infection (CDI) has been increasing in incidence and severity in recent years, coincident with the spread of a "hypervirulent" strain, REA type BI (ribotype 027, PFGE NAP 1). 19755166 2009
CUI: C0687720
Disease: Central Diabetes Insipidus
Central Diabetes Insipidus 		0.100 GeneticVariation disease BEFREE Clostridium difficile infection (CDI) has been increasing in incidence and severity in recent years, coincident with the spread of a "hypervirulent" strain, REA type BI (ribotype 027, PFGE NAP 1). 19755166 2009
CUI: C1411966
Disease: Clostridium; difficile (disorder)
Clostridium; difficile (disorder) 		0.100 Biomarker disease BEFREE Clostridium difficile strains belonging to the PCR ribotype 027, pulse-field gel electrophoresis (PFGE) type NAP1, toxinotype III and restriction endonuclease analysis group BI harbouring mutations in the tcdC gene and possessing binary toxin components A and B have been described to cause epidemics with increased morbidity and mortality. 19664132 2009
CUI: C0343386
Disease: Clostridium difficile infection
Clostridium difficile infection 		0.100 Biomarker disease BEFREE Evaluation of the Cepheid Xpert Clostridium difficile Epi assay for diagnosis of Clostridium difficile infection and typing of the NAP1 strain at a cancer hospital. 20943860 2010
CUI: C1411966
Disease: Clostridium; difficile (disorder)
Clostridium; difficile (disorder) 		0.100 Biomarker disease BEFREE Evaluation of the Cepheid Xpert Clostridium difficile Epi assay for diagnosis of Clostridium difficile infection and typing of the NAP1 strain at a cancer hospital. 20943860 2010
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.010 GeneticVariation group BEFREE Evaluation of the Cepheid Xpert Clostridium difficile Epi assay for diagnosis of Clostridium difficile infection and typing of the NAP1 strain at a cancer hospital. 20943860 2010
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.010 GeneticVariation group BEFREE Evaluation of the Cepheid Xpert Clostridium difficile Epi assay for diagnosis of Clostridium difficile infection and typing of the NAP1 strain at a cancer hospital. 20943860 2010
CUI: C0009447
Disease: Common Variable Immunodeficiency
Common Variable Immunodeficiency 		0.100 GeneticVariation disease GWASDB Genome-wide association identifies diverse causes of common variable immunodeficiency. 21497890 2011
CUI: C0687720
Disease: Central Diabetes Insipidus
Central Diabetes Insipidus 		0.100 Biomarker disease BEFREE The gold standard was the toxigenic culture for the diagnosis of CDI and PCR ribotyping for the identification of the NAP1/027/BI strain. 21487764 2011
CUI: C1411966
Disease: Clostridium; difficile (disorder)
Clostridium; difficile (disorder) 		0.100 Biomarker disease BEFREE Association of relapse of Clostridium difficile disease with BI/NAP1/027. 23052318 2012
CUI: C0011991
Disease: Diarrhea
Diarrhea 		0.020 Biomarker phenotype BEFREE The dominant 072 ribotype was carried by 43% (12/28) of subjects, while the hypervirulent strain R027 (B1/NAP1/027) was isolated from 3 subjects (11%), 2 of whom displayed C. difficile associated diarrhea (CDAD) symptoms at the time of sampling. 22162545 2012
CUI: C0343386
Disease: Clostridium difficile infection
Clostridium difficile infection 		0.100 GeneticVariation disease BEFREE The NAP1/BI/027 strain causes more-severe disease than other widely prevalent strains and affects patients who were not traditionally thought to be at risk for Clostridium difficile infection. 23182524 2013
CUI: C1411966
Disease: Clostridium; difficile (disorder)
Clostridium; difficile (disorder) 		0.100 Biomarker disease BEFREE Real-time polymerase chain reaction method for detection of toxigenic Clostridium difficile from stools and presumptive identification of NAP1 clone. 23182075 2013
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.030 Biomarker disease BEFREE Genome-wide screening reveals that miR-195 targets the TNF-α/NF-κB pathway by down-regulating IκB kinase alpha and TAB3 in hepatocellular carcinoma. 23487264 2013
CUI: C0152136
Disease: Low Tension Glaucoma
Low Tension Glaucoma 		0.010 Biomarker disease BEFREE TAP showed that NAP1, TANK and TBKBP1 interact with TBK1 and are good candidates for contributing to NTG. 23286385 2013
CUI: C0343386
Disease: Clostridium difficile infection
Clostridium difficile infection 		0.100 Biomarker disease BEFREE Clostridium difficile infection after allogeneic hematopoietic stem cell transplant: strain diversity and outcomes associated with NAP1/027. 24973628 2014