|
Common Variable Immunodeficiency
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association identifies diverse causes of common variable immunodeficiency.
|
21497890 |
2011 |
|
Liver carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Genome-wide screening reveals that miR-195 targets the TNF-α/NF-κB pathway by down-regulating IκB kinase alpha and TAB3 in hepatocellular carcinoma.
|
23487264 |
2013 |
|
Clostridium difficile infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Impact of the NAP-1 strain on disease severity, mortality, and recurrence of healthcare-associated Clostridium difficile infection.
|
28645479 |
2017 |
|
Clostridium; difficile (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Importantly, ecteinamycin demonstrated potent activity against the toxigenic strain of Clostridium difficile NAP1/B1/027 (MIC = 59 ng/μL), as well as other toxigenic and nontoxigenic C. difficile isolates both in vitro and in vivo.
|
28708379 |
2017 |
|
Diarrhea
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
In a 2009 outbreak of C. difficile-associated diarrhea that was recorded in a major Costa Rican hospital, the hypervirulent NAP1 strain (45%) predominated together with a local genotype variant (NAPCR1, 31%).
|
27165560 |
2016 |
|
Tumor Cell Invasion
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
In addition, TAB3 knockdown decreased Survivin expression and suppressed colorectal cancer cell migration and invasion <i>in vitro</i>, and reduced liver metastasis <i>in vivo</i>.
|
29290971 |
2017 |
|
Secondary malignant neoplasm of liver
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, TAB3 knockdown decreased Survivin expression and suppressed colorectal cancer cell migration and invasion <i>in vitro</i>, and reduced liver metastasis <i>in vivo</i>.
|
29290971 |
2017 |
|
Alzheimer's Disease
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In addition, hNap1BP bound to the SH3 domain of c-Abl and Nck. hNap1BP is expressed ubiquitously in various tissues like human Nap1, and intriguingly these genes are co-expressed in hippocampus and cerebral cortex in mouse brain where AD pathological features are strongly evident.
|
11418237 |
2001 |
|
Heart Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
In our study, we first investigated the role of TAB3 in ischemia heart diseases.
|
28462515 |
2017 |
|
Myocardial Ischemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
In summary, our findings indicate that the absence of TAB3 plays a harmful role in ischemic heart disease.
|
28462515 |
2017 |
|
Psoriasis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this case, local pharmacologic down-regulation of NAP-1/IL-8 activity could be a promising therapeutic strategy in PS.
|
1711550 |
1991 |
|
Neoplasm Metastasis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
In this study, we demonstrated that TAB3 is upregulated in colorectal cancer tissues and that high TAB3 levels correlated with tumor metastasis and a poor prognosis in colorectal cancer.
|
29290971 |
2017 |
|
Secondary Neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
In this study, we demonstrated that TAB3 is upregulated in colorectal cancer tissues and that high TAB3 levels correlated with tumor metastasis and a poor prognosis in colorectal cancer.
|
29290971 |
2017 |
|
Central Diabetes Insipidus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Infection with the epidemic NAP-1 strain was not associated with metronidazole failure in endemic CDI.
|
19081526 |
2008 |
|
Arthritis, Psoriatic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, in unstimulated PBMCs, TAB3 expression was significantly downregulated in PA patients compared to atopic non-PA individuals.
|
30893695 |
2019 |
|
Hypophosphatemia
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
It is characterized by renal phosphate wasting, leading to hypophosphatemia and an inappropriately normal or low serum level of 1,25(OH)2 vitamin D. Previous studies have pointed to a circulating factor or phosphatonin-inhibiting phosphate transport by decreasing mRNA of the proximal tubule NaP(i) cotransporter NaPi-2A.
|
15454393 |
2005 |
|
ovarian neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Loss of TAB3 expression by shRNA exhibits suppressive bioactivity and increased chemical sensitivity of ovarian cancer cell lines via the NF-κB pathway.
|
27651027 |
2016 |
|
Malignant neoplasm of ovary
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Loss of TAB3 expression by shRNA exhibits suppressive bioactivity and increased chemical sensitivity of ovarian cancer cell lines via the NF-κB pathway.
|
27651027 |
2016 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Loss of TAB3 expression by shRNA exhibits suppressive bioactivity and increased chemical sensitivity of ovarian cancer cell lines via the NF-κB pathway.
|
27651027 |
2016 |
|
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Mechanistic studies further reveal that the binding of NAP1 to the cellular chaperone heat shock protein 90 (HSP90) is required for its protein stabilization, and NAP1 plays an essential role in HSP90-mediated invasion and metastasis by provoking MMP9 activation and the epithelial-to-mesenchymal transition in NSCLC cells.
|
30867003 |
2019 |
|
Non-Small Cell Lung Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Nck-associated protein 1 (NAP1/NCKAP1) is highly expressed in primary non-small-cell lung cancer (NSCLC) when compared with adjacent normal lung tissues, and its expression levels are strongly associated with the histologic tumor grade, metastasis and poor survival rate of NSCLC patients.
|
30867003 |
2019 |
|
Disseminated Malignant Neoplasm
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Our insights demonstrate the importance and functional regulation of the HSP90-NAP1 protein complex in cancer metastatic signaling, which spur new avenues to target this interaction as a novel approach to block NSCLC metastasis.
|
30867003 |
2019 |
|
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Our insights demonstrate the importance and functional regulation of the HSP90-NAP1 protein complex in cancer metastatic signaling, which spur new avenues to target this interaction as a novel approach to block NSCLC metastasis.
|
30867003 |
2019 |
|
Central Diabetes Insipidus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Over 75 % of CDIs with NAP1 was hospital-acquired, and more often proceeded with generalized infection (p < 0.05).
|
24213847 |
2014 |
|
Sepsis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Over 75 % of CDIs with NAP1 was hospital-acquired, and more often proceeded with generalized infection (p < 0.05).
|
24213847 |
2014 |