Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
Childhood Osteosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Cyclin G-associated kinase is necessary for osteosarcoma cell proliferation and receptor trafficking.
|
20881269 |
2010 |
Hepatitis C
|
0.040 |
Biomarker
|
disease |
BEFREE |
We demonstrated that the host kinases AAK1 and GAK regulate HCV infection by controlling these clathrin-associated APs.
|
29535204 |
2018 |
Hepatitis C
|
0.040 |
Biomarker
|
disease |
BEFREE |
Furthermore, AAK1 and GAK, serine/threonine kinases known to stimulate binding of AP2M1 to host cargo proteins, regulate core-AP2M1 binding and are essential for HCV assembly.
|
22916011 |
2012 |
Hepatitis C
|
0.040 |
Biomarker
|
disease |
BEFREE |
We previously reported that AAK1 and GAK, kinase regulators of the host adaptor proteins AP1 and AP2, are essential for hepatitis C virus (HCV) infection, but the underlying mechanism and relevance to other viruses or in vivo infections remained unknown.
|
28240606 |
2017 |
Hepatitis C
|
0.040 |
Biomarker
|
disease |
BEFREE |
AP-2-associated protein kinase 1 and cyclin G-associated kinase regulate hepatitis C virus entry and are potential drug targets.
|
25653444 |
2015 |
High density lipoprotein measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.
|
30275531 |
2018 |
Hormone refractory prostate cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Cyclin G-associated kinase: a novel androgen receptor-interacting transcriptional coactivator that is overexpressed in hormone refractory prostate cancer.
|
16161052 |
2006 |
Lymphocyte Count measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes.
|
22286170 |
2012 |
Osteosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Cyclin G-associated kinase is necessary for osteosarcoma cell proliferation and receptor trafficking.
|
20881269 |
2010 |
Osteosarcoma of bone
|
0.010 |
Biomarker
|
disease |
BEFREE |
Cyclin G-associated kinase is necessary for osteosarcoma cell proliferation and receptor trafficking.
|
20881269 |
2010 |
Parkinson Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our results supported the association between the rs11248051 variant in GAK and PD risk in a Taiwanese population.
|
24039160 |
2013 |
Parkinson Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
GAK rs1564282 and DGKQ rs11248060 increase the risk for PD in Chinese patients.
|
23618683 |
2013 |
Parkinson Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Together, these findings provide strong evidence for GAK clathrin-binding- and J-domain transcripts' influence on PD pathogenicity, and for a role for GAK in regulating synaptic function in PD.
|
27508417 |
2016 |
Parkinson Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Full sequencing of TMEM175/GAK/DGKQ followed by genotyping of specific associated variants was performed in PD (n = 1,575) and rapid eye movement sleep behavior disorder (RBD) patients (n = 533) and in controls (n = 1,583).
|
31658403 |
2020 |
Parkinson Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We used 2 PD case-control data sets (Washington University and the Parkinson's Progression Markers Initiative) to determine whether polymorphisms located at the GWAS top hits (GBA, ACMSD/TMEM163, STK39, MCCC1/LAMP3, GAK/TMEM175, SNCA, and MAPT) show association with AAO or motor progression.
|
26601739 |
2016 |
Parkinson Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The single-nucleotide polymorphism (SNP) rs1564282 of GAK gene has a significant association to the risk of PD among Caucasian populations.
|
23826309 |
2013 |
Parkinson Disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease.
|
20711177 |
2010 |
Parkinson Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Besides, post-hoc analysis confirmed GAK/DGKQ, HLA and MAPT as PD risk loci among the Dutch (GAK/DGKQ, rs2242235: P = 1.22 × 10(-4), OR = 1.51; HLA, rs4248166: P = 4.39 × 10(-5), OR = 1.36; and MAPT, rs3785880: P = 1.9 × 10(-3), OR = 1.19).
|
21248740 |
2011 |
Parkinson Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
We describe recent advances on roles of kinases TAOK2, TNIK and CDKL5 in neuronal development and the converging pathways of LRRK2, PINK1 and GAK in Parkinson's Disease.
|
29241837 |
2018 |
Parkinson Disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Detection and interpretation of shared genetic influences on 42 human traits.
|
27182965 |
2016 |
Parkinson Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
This gene is closely related to GAK, identified as a possible PD susceptibility gene in the GWAS of the familial PD cases.
|
19772629 |
2009 |
Parkinson Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Cyclin-G-associated kinase (GAK), a PD susceptibility gene identified through genome-wide association studies (GWAS), is a ubiquitous serine/threonine kinase involved in clathrin uncoating, though its PD-related function remains elusive.
|
28147270 |
2017 |
Parkinson Disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genomewide association study for susceptibility genes contributing to familial Parkinson disease.
|
18985386 |
2009 |
Parkinson Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
While MAPT has been considered a PD candidate gene and has been observed in association with PD in other GWAS, GAK is a new candidate for investigation in future studies.
|
21058943 |
2011 |