Hormone refractory prostate cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Cyclin G-associated kinase: a novel androgen receptor-interacting transcriptional coactivator that is overexpressed in hormone refractory prostate cancer.
|
16161052 |
2006 |
Parkinson Disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genomewide association study for susceptibility genes contributing to familial Parkinson disease.
|
18985386 |
2009 |
Parkinson Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
This gene is closely related to GAK, identified as a possible PD susceptibility gene in the GWAS of the familial PD cases.
|
19772629 |
2009 |
Parkinson Disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease.
|
20711177 |
2010 |
Parkinson Disease
|
0.500 |
Biomarker
|
disease |
CTD_human |
Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease.
|
20711177 |
2010 |
Parkinson Disease
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease.
|
20711177 |
2010 |
Osteosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Cyclin G-associated kinase is necessary for osteosarcoma cell proliferation and receptor trafficking.
|
20881269 |
2010 |
Osteosarcoma of bone
|
0.010 |
Biomarker
|
disease |
BEFREE |
Cyclin G-associated kinase is necessary for osteosarcoma cell proliferation and receptor trafficking.
|
20881269 |
2010 |
Childhood Osteosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Cyclin G-associated kinase is necessary for osteosarcoma cell proliferation and receptor trafficking.
|
20881269 |
2010 |
Parkinson Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
While MAPT has been considered a PD candidate gene and has been observed in association with PD in other GWAS, GAK is a new candidate for investigation in future studies.
|
21058943 |
2011 |
Parkinson Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Besides, post-hoc analysis confirmed GAK/DGKQ, HLA and MAPT as PD risk loci among the Dutch (GAK/DGKQ, rs2242235: P = 1.22 × 10(-4), OR = 1.51; HLA, rs4248166: P = 4.39 × 10(-5), OR = 1.36; and MAPT, rs3785880: P = 1.9 × 10(-3), OR = 1.19).
|
21248740 |
2011 |
Parkinson Disease
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Cyclin-G-associated kinase modifies α-synuclein expression levels and toxicity in Parkinson's disease: results from the GenePD Study.
|
21258085 |
2011 |
Parkinson Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
These observations provide evidence that GAK is associated with PD risk and suggest that GAK and α-synuclein interact in a pathway involved in PD pathogenesis.
|
21258085 |
2011 |
Parkinson Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Functional studies of GAK to unravel its role in the pathophysiologic pathway of PD will be useful.
|
22198721 |
2012 |
Lymphocyte Count measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes.
|
22286170 |
2012 |
Parkinson Disease
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database.
|
22438815 |
2012 |
Hepatitis C
|
0.040 |
Biomarker
|
disease |
BEFREE |
Furthermore, AAK1 and GAK, serine/threonine kinases known to stimulate binding of AP2M1 to host cargo proteins, regulate core-AP2M1 binding and are essential for HCV assembly.
|
22916011 |
2012 |
Parkinson Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
GAK rs1564282 and DGKQ rs11248060 increase the risk for PD in Chinese patients.
|
23618683 |
2013 |
Parkinson Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The single-nucleotide polymorphism (SNP) rs1564282 of GAK gene has a significant association to the risk of PD among Caucasian populations.
|
23826309 |
2013 |
Parkinson Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our results supported the association between the rs11248051 variant in GAK and PD risk in a Taiwanese population.
|
24039160 |
2013 |
Parkinson Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies identified PARK16 variants rs823128 and rs947211, PARK17/GAK rs11248051 and PARK18/HLA-DRA rs3129882 as risk factors for Parkinson's disease (PD).
|
24373818 |
2014 |
Tremor
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Based on motor Unified Parkinson's Disease Rating Scale subscores, MAPT (P = .0002) and CCDC62 (P = .003) were predominantly associated with bradykinesia, and we further discovered associations between SREBF1 (rs11868035; P = .005) and gait impairment, SNCA (rs356220; P = .04) and rigidity, and GAK (rs1564282; P = .03) and tremor.
|
24514572 |
2014 |
Hepatitis C
|
0.040 |
Biomarker
|
disease |
BEFREE |
AP-2-associated protein kinase 1 and cyclin G-associated kinase regulate hepatitis C virus entry and are potential drug targets.
|
25653444 |
2015 |
Parkinson Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We used 2 PD case-control data sets (Washington University and the Parkinson's Progression Markers Initiative) to determine whether polymorphisms located at the GWAS top hits (GBA, ACMSD/TMEM163, STK39, MCCC1/LAMP3, GAK/TMEM175, SNCA, and MAPT) show association with AAO or motor progression.
|
26601739 |
2016 |
Parkinson Disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Detection and interpretation of shared genetic influences on 42 human traits.
|
27182965 |
2016 |