|
Esophageal Neoplasms
|
0.110 |
GeneticVariation
|
group |
GWASCAT |
Genome-wide association study identifies common variants in SLC39A6 associated with length of survival in esophageal squamous-cell carcinoma.
|
23644492 |
2013 |
|
Squamous cell carcinoma
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study identifies common variants in SLC39A6 associated with length of survival in esophageal squamous-cell carcinoma.
|
23644492 |
2013 |
|
Squamous cell carcinoma
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies common variants in SLC39A6 associated with length of survival in esophageal squamous-cell carcinoma.
|
23644492 |
2013 |
|
Tumor Progression
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
We investigated the function of SLC39A6 and ways in which this variant affects tumor progression by studying ESCC samples and cell lines.
|
28209530 |
2017 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our data suggest that LIV-1 is a promising candidate for a novel marker for breast cancer patients with better outcome.
|
15986450 |
2005 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
We then estimate a gene association network from gene expression data taken from a breast cancer tumor study, showing that scale-free structure prior recovers hubs, including the previously unknown hub SLC39A6, which is a zinc transporter that has been implicated with the spread of breast cancer to the lymph nodes.
|
21079769 |
2010 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
CTD_human |
Combining the crucial role that zinc plays in cell growth and the proven role of metalloproteases in metastasis presents an exciting indication of how LIV-1 plays a role in breast cancer progression.
|
12839489 |
2003 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
ZIP6, 7, and 10 contribute to human breast cancer progression.
|
30270320 |
2018 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
Zinc and its transporter ZIP6 are key mediators of breast cancer cell survival under high glucose conditions.
|
28833062 |
2017 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
Herein, the physiological effects of zinc are reviewed in light of this mineral's role in cancer growth with specific attention being given to LIV-1 and the potential importance of this transporter to breast cancer etiology.
|
22852056 |
2012 |
|
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Combining the crucial role that zinc plays in cell growth and the proven role of metalloproteases in metastasis presents an exciting indication of how LIV-1 plays a role in breast cancer progression.
|
12839489 |
2003 |
|
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
ZIP6, 7, and 10 contribute to human breast cancer progression.
|
30270320 |
2018 |
|
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Herein, the physiological effects of zinc are reviewed in light of this mineral's role in cancer growth with specific attention being given to LIV-1 and the potential importance of this transporter to breast cancer etiology.
|
22852056 |
2012 |
|
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We then estimate a gene association network from gene expression data taken from a breast cancer tumor study, showing that scale-free structure prior recovers hubs, including the previously unknown hub SLC39A6, which is a zinc transporter that has been implicated with the spread of breast cancer to the lymph nodes.
|
21079769 |
2010 |
|
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Zinc and its transporter ZIP6 are key mediators of breast cancer cell survival under high glucose conditions.
|
28833062 |
2017 |
|
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our data suggest that LIV-1 is a promising candidate for a novel marker for breast cancer patients with better outcome.
|
15986450 |
2005 |
|
Neoplasm Metastasis
|
0.380 |
Biomarker
|
phenotype |
BEFREE |
Despite LIV-1 participates in cancer growth and metastasis, little is known about the association of LIV-1 with human liver cancer development.
|
23437163 |
2013 |
|
Neoplasm Metastasis
|
0.380 |
Biomarker
|
phenotype |
BEFREE |
Despite the implication of LIV-1 in cancer growth and metastasis, there has been no study to determine the role of LIV-1 in prostate cancer progression.
|
22110740 |
2011 |
|
Neoplasm Metastasis
|
0.380 |
Biomarker
|
phenotype |
BEFREE |
Our results indicate a causative role for ZIP6 in cell motility and migration, providing ZIP6 as a new target for prediction of clinical cancer spread and also suggesting a ZIP6-dependent mechanism of tumour metastasis.
|
23919497 |
2013 |
|
Neoplasm Metastasis
|
0.380 |
Biomarker
|
phenotype |
BEFREE |
LIV-1 (ZIP6) was first described in 1988 as an estrogen regulated gene with later work suggesting a role for this transporter in cancer growth and metastasis.
|
22852056 |
2012 |
|
Neoplasm Metastasis
|
0.380 |
Biomarker
|
phenotype |
BEFREE |
ZIP6 is associated with breast tumor grade, size, and stage, suggesting that it is a potent driving force toward malignancy; ZIP7 plays an important role in tamoxifen-resistant breast cancer cells, and ZIP10 is involved in invasion and metastasis of breast cancer cells.
|
30270320 |
2018 |
|
Neoplasm Metastasis
|
0.380 |
Biomarker
|
phenotype |
CTD_human |
Combining the crucial role that zinc plays in cell growth and the proven role of metalloproteases in metastasis presents an exciting indication of how LIV-1 plays a role in breast cancer progression.
|
12839489 |
2003 |
|
Neoplasm Metastasis
|
0.380 |
Biomarker
|
phenotype |
BEFREE |
In conclusion, we newly determined that miR-192 targeted the SLC39A6/SNAIL pathway to reduce tumor metastasis in HCC cells.
|
26684241 |
2016 |
|
Mammary Neoplasms
|
0.350 |
Biomarker
|
group |
CTD_human |
Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters.
|
12839489 |
2003 |
|
Mammary Neoplasms
|
0.350 |
Biomarker
|
group |
LHGDN |
Genes that co-cluster with estrogen receptor alpha in microarray analysis of breast biopsies.
|
11911440 |
2001 |