TXN2, thioredoxin 2, 25828

N. diseases: 76; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4225200
Disease: COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 29
COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 29 		0.500 Biomarker disease GENOMICS_ENGLAND Human thioredoxin 2 deficiency impairs mitochondrial redox homeostasis and causes early-onset neurodegeneration. 26626369 2016
CUI: C4225200
Disease: COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 29
COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 29 		0.500 Biomarker disease CTD_human
CUI: C4225200
Disease: COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 29
COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 29 		0.500 Biomarker disease GENOMICS_ENGLAND
CUI: C0080178
Disease: Spina Bifida
Spina Bifida 		0.310 Biomarker disease CTD_human Genetic polymorphisms in the thioredoxin 2 (TXN2) gene and risk for spina bifida. 19165900 2009
CUI: C0080178
Disease: Spina Bifida
Spina Bifida 		0.310 GeneticVariation disease BEFREE Genetic polymorphisms in the thioredoxin 2 (TXN2) gene and risk for spina bifida. 19165900 2009
CUI: C0038219
Disease: Status Dysraphicus
Status Dysraphicus 		0.300 Biomarker disease CTD_human Genetic polymorphisms in the thioredoxin 2 (TXN2) gene and risk for spina bifida. 19165900 2009
CUI: C0266508
Disease: Rachischisis
Rachischisis 		0.300 Biomarker disease CTD_human Genetic polymorphisms in the thioredoxin 2 (TXN2) gene and risk for spina bifida. 19165900 2009
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.200 Biomarker disease RGD [The change of thioredoxin system in myocardial tissue of type 2 diabetic rats undergoing myocardial injury]. 20571744 2010
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.200 Biomarker disease RGD The expression of thioredoxin-1/thioredoxin-2 and thioredoxin reductase-1/thioredoxin reductase-2 was significantly decreased in rats with ischemia/reperfusion injury, while it was increased by tetramethyl pyrazine administration. 19128823 2009
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury 		0.200 Biomarker phenotype RGD Redox regulation of resveratrol-mediated switching of death signal into survival signal. 18045550 2008
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.200 Biomarker disease RGD Effect of high glucose on gene expression in mesangial cells: upregulation of the thiol pathway is an adaptational response. 15039483 2004
CUI: C0013363
Disease: Dysautonomia
Dysautonomia 		0.100 Biomarker disease HPO
CUI: C0013421
Disease: Dystonia
Dystonia 		0.100 Biomarker phenotype HPO
CUI: C0025958
Disease: Microcephaly
Microcephaly 		0.100 Biomarker disease HPO
CUI: C0026838
Disease: Muscle Spasticity
Muscle Spasticity 		0.100 Biomarker phenotype HPO
CUI: C0027746
Disease: Nerve Degeneration
Nerve Degeneration 		0.100 Biomarker phenotype HPO
CUI: C0029124
Disease: Optic Atrophy
Optic Atrophy 		0.100 Biomarker disease HPO
CUI: C0029132
Disease: Disorder of the optic nerve
Disorder of the optic nerve 		0.100 Biomarker group HPO
CUI: C0035309
Disease: Retinal Diseases
Retinal Diseases 		0.100 Biomarker group HPO
CUI: C0036572
Disease: Seizures
Seizures 		0.100 Biomarker phenotype HPO
CUI: C0232466
Disease: Feeding difficulties
Feeding difficulties 		0.100 Biomarker phenotype HPO
CUI: C0241816
Disease: Global brain atrophy
Global brain atrophy 		0.100 Biomarker phenotype HPO
CUI: C0494475
Disease: Tonic - clonic seizures
Tonic - clonic seizures 		0.100 Biomarker disease HPO
CUI: C0557874
Disease: Global developmental delay
Global developmental delay 		0.100 Biomarker disease HPO
CUI: C0563243
Disease: Poor coordination
Poor coordination 		0.100 Biomarker phenotype HPO