|
Colorectal Carcinoma
|
0.320 |
Biomarker
|
disease |
BEFREE |
Thus, to our knowledge for the first time in the literature, we show that MTHFD1L is involved in CRC progression and that blocking of MTHFD1L decreases the growth of colon cancer cells, thus providing an avenue to target this enzyme with small molecule inhibitors.
|
31421459 |
2019 |
|
Colorectal Carcinoma
|
0.320 |
Biomarker
|
disease |
BEFREE |
These results suggest that mtC(1)-THFS may participate in the progression of colorectal cancer by conferring growth advantage and could be a new molecular target for cancer therapy.
|
15013446 |
2004 |
|
Colorectal Carcinoma
|
0.320 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Neural tube defects X-linked
|
0.200 |
Biomarker
|
disease |
MGD |
Deletion of Mthfd1l causes embryonic lethality and neural tube and craniofacial defects in mice.
|
23267094 |
2013 |
|
Spina Bifida, X-Linked
|
0.200 |
Biomarker
|
disease |
MGD |
Deletion of Mthfd1l causes embryonic lethality and neural tube and craniofacial defects in mice.
|
23267094 |
2013 |
|
Neural tube defect, folate-sensitive
|
0.200 |
Biomarker
|
disease |
MGD |
Deletion of Mthfd1l causes embryonic lethality and neural tube and craniofacial defects in mice.
|
23267094 |
2013 |
|
Spina Bifida, Folate-Sensitive
|
0.200 |
Biomarker
|
disease |
MGD |
Deletion of Mthfd1l causes embryonic lethality and neural tube and craniofacial defects in mice.
|
23267094 |
2013 |
|
Coronary heart disease
|
0.120 |
GeneticVariation
|
disease |
BEFREE |
The Ch9p21 SNPs rs1333049 (OR 1.17; 95% confidence limits 1.11-1.24) and rs10757274 (OR 1.17; 1.09-1.26), MIA3 rs17465637 (OR 1.10; 1.04-1.15), Ch2q36 rs2943634 (OR 1.08; 1.03-1.14), APC rs383830 (OR 1.10; 1.02, 1.18), MTHFD1L rs6922269 (OR 1.10; 1.03, 1.16), CXCL12 rs501120 (OR 1.12; 1.04, 1.20), and SMAD3 rs17228212 (OR 1.11; 1.05, 1.17) were all associated with CHD risk, but not with the CHD biomarkers and risk factors measured.
|
21804106 |
2012 |
|
Alzheimer's Disease
|
0.120 |
Biomarker
|
disease |
BEFREE |
We found no evidence of association between the MTHFD1L marker and susceptibility to Alzheimer's disease in our sample.
|
21383495 |
2011 |
|
Alzheimer's Disease
|
0.120 |
GeneticVariation
|
disease |
BEFREE |
Our data revealed that the allele (A) of the rs11754661 polymorphism within MTHFD1L gene may contribute to AD risk in the Chinese Han population.
|
21741665 |
2011 |
|
Coronary heart disease
|
0.120 |
GeneticVariation
|
disease |
BEFREE |
Nine loci were statistically associated with incident CHD events in white participants: 9p21 (rs10757278; P=4.7 × 10(-41)), 16q23.1 (rs2549513; P=0.0004), 6p24.1 (rs499818; P=0.0002), 2q36.3 (rs2943634; P=6.7 × 10(-6)), MTHFD1L (rs6922269, P=5.1 × 10(-10)), APOE (rs429358; P=2.7×10(-18)), ZNF627 (rs4804611; P=5.0 × 10(-8)), CXCL12 (rs501120; P=1.4 × 10(-6)) and LPL (rs268; P=2.7 × 10(-17)).
|
22042884 |
2011 |
|
Coronary heart disease
|
0.120 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
|
21347282 |
2011 |
|
Alzheimer's Disease
|
0.120 |
GeneticVariation
|
disease |
GWASDB |
Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities.
|
20885792 |
2010 |
|
Alzheimer's Disease
|
0.120 |
GeneticVariation
|
disease |
GWASCAT |
Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities.
|
20885792 |
2010 |
|
Coronary heart disease
|
0.120 |
GeneticVariation
|
disease |
GWASCAT |
Genomewide association analysis of coronary artery disease.
|
17634449 |
2007 |
|
Coronary heart disease
|
0.120 |
GeneticVariation
|
disease |
GWASDB |
Genomewide association analysis of coronary artery disease.
|
17634449 |
2007 |
|
Coronary Artery Disease
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in MTHFD1L, including rs6922269, have been implicated in risk for coronary artery disease (CAD).
|
24618918 |
2014 |
|
Coronary Artery Disease
|
0.110 |
GeneticVariation
|
disease |
GWASDB |
Genomewide association analysis of coronary artery disease.
|
17634449 |
2007 |
|
Peripheral Arterial Diseases
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Genetic Variants in the Bone Morphogenic Protein Gene Family Modify the Association between Residential Exposure to Traffic and Peripheral Arterial Disease.
|
27082954 |
2016 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of schizophrenia in Ashkenazi Jews.
|
26198764 |
2015 |
|
Low density lipoprotein cholesterol measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
|
Serum LDL cholesterol measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
|
Corneal Topography
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Association of polymorphisms in the hepatocyte growth factor gene promoter with keratoconus.
|
22003120 |
2011 |
|
Neural Tube Defects
|
0.080 |
Biomarker
|
group |
BEFREE |
In addition to well established mechanisms in one-carbon metabolism, formate may play an important role in early pregnancy by preventing the onset of neural tube defects in sensitive strains of mice, including mice with deficiencies in MTHFD1L, the glycine cleavage system and the mitochondrial folate transporter.
|
31688093 |
2020 |
|
Neural Tube Defects
|
0.080 |
GeneticVariation
|
group |
BEFREE |
Deletion of Mthfd1l causes embryonic lethality, developmental delay, and neural tube defects in mice.
|
31518072 |
2019 |