|
Dwarfism
|
0.410 |
Biomarker
|
disease |
BEFREE |
Here we identified dominant mutations in the gene encoding the transcriptional repressor and MeCP2 interactor switch-insensitive 3 family member A (SIN3A; chromosome 15q24.2) in individuals who, in addition to mild intellectual disability and ASD, share striking features, including facial dysmorphisms, microcephaly and short stature.
|
27399968 |
2016 |
|
Intellectual Disability
|
0.410 |
Biomarker
|
group |
BEFREE |
Together, our data establish that haploinsufficiency of SIN3A is associated with mild syndromic intellectual disability and that SIN3A can be considered to be a key transcriptional regulator of cortical brain development.
|
27399968 |
2016 |
|
Autism Spectrum Disorders
|
0.310 |
Biomarker
|
disease |
BEFREE |
Here we identified dominant mutations in the gene encoding the transcriptional repressor and MeCP2 interactor switch-insensitive 3 family member A (SIN3A; chromosome 15q24.2) in individuals who, in addition to mild intellectual disability and ASD, share striking features, including facial dysmorphisms, microcephaly and short stature.
|
27399968 |
2016 |
|
Mild Mental Retardation
|
0.110 |
Biomarker
|
disease |
BEFREE |
Here we identified dominant mutations in the gene encoding the transcriptional repressor and MeCP2 interactor switch-insensitive 3 family member A (SIN3A; chromosome 15q24.2) in individuals who, in addition to mild intellectual disability and ASD, share striking features, including facial dysmorphisms, microcephaly and short stature.
|
27399968 |
2016 |
|
Malignant neoplasm of breast
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Additionally, we analyzed microarray data sets to identify correlations of SIN3A and SIN3B expression with survival in patients with breast cancer.
|
27780928 |
2016 |
|
Malignant neoplasm of breast
|
0.050 |
Biomarker
|
disease |
BEFREE |
Further, our study identified the ERα-NEAT1-FOXN3/NEAT1/SIN3A-GATA3 axis that is implicated in breast cancer metastasis, providing a mechanistic insight into the pathophysiological function of FOXN3.
|
28805661 |
2017 |
|
Malignant neoplasm of breast
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
These observations reveal that the SIN3A mutation has lost its transcriptional repression function due to its cytoplasmic localization, and that this repression may contribute to the progression of breast cancer.
|
30375428 |
2018 |
|
Malignant neoplasm of breast
|
0.050 |
Biomarker
|
disease |
BEFREE |
Our data indicate that LSD1 is a functional alternative subunit of the SIN3A/HDAC complex, providing a molecular basis for the interplay of histone demethylation and deacetylation in chromatin remodelling, and suggest that the LSD1/SIN3A/HDAC complex could be a target for breast cancer therapeutic strategies.
|
29741645 |
2018 |
|
Malignant neoplasm of breast
|
0.050 |
Biomarker
|
disease |
BEFREE |
Loss of Sin3A inhibited breast cancer cell growth by increasing apoptosis without affecting cell cycle progression.
|
20920219 |
2010 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
The short isoform p42 Ebp1, which is actual binding partner of ErbB3 has been implicated as a tumor suppressor with many binding partners such as Rb, HDAC2, Sin3A and the p85 subunit of PI3K with HSP70/CHIP, inhibiting its own antiproliferative activity or inhibiting PI3K activity.
|
27130196 |
2016 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
SIGNIFICANCE: This study delineates the transcriptional regulatory complex Sin3A as a mediator of STAT3 transcriptional repressor activity and identifies the STAT3/Sin3A axis as a druggable target to antagonize STAT3-addicted tumors.
|
30692217 |
2019 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
In tissue sections from the breast cancer patient with the SIN3A c.2830 C>T mutation, cytoplasmic SIN3A localization was detected within the tumor regions where nuclear enlargement was observed.
|
30375428 |
2018 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Here, we report in a murine model of skin squamous cell carcinoma (SCC) that nuclear FAK regulates Runx1-dependent transcription of insulin-like growth factor binding protein 3 (IGFBP3), and that this regulates SCC cell-cycle progression and tumor growth <i>in vivo</i> Furthermore, we identified a novel molecular complex between FAK and Runx1 in the nucleus of SCC cells and showed that FAK interacted with a number of Runx1-regulatory proteins, including Sin3a and other epigenetic modifiers known to alter Runx1 transcriptional function through posttranslational modification.
|
28807942 |
2017 |
|
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
We show that Sin3A is downregulated in a variety of human tumors and that Src, JNK, RhoA and PP1B/β-Catenin are regulated in a manner analogous to our Drosophila models.
|
22890320 |
2013 |
|
Breast Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Our data indicate that LSD1 is a functional alternative subunit of the SIN3A/HDAC complex, providing a molecular basis for the interplay of histone demethylation and deacetylation in chromatin remodelling, and suggest that the LSD1/SIN3A/HDAC complex could be a target for breast cancer therapeutic strategies.
|
29741645 |
2018 |
|
Breast Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Loss of Sin3A inhibited breast cancer cell growth by increasing apoptosis without affecting cell cycle progression.
|
20920219 |
2010 |
|
Breast Carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Additionally, we analyzed microarray data sets to identify correlations of SIN3A and SIN3B expression with survival in patients with breast cancer.
|
27780928 |
2016 |
|
Breast Carcinoma
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
These observations reveal that the SIN3A mutation has lost its transcriptional repression function due to its cytoplasmic localization, and that this repression may contribute to the progression of breast cancer.
|
30375428 |
2018 |
|
Breast Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Further, our study identified the ERα-NEAT1-FOXN3/NEAT1/SIN3A-GATA3 axis that is implicated in breast cancer metastasis, providing a mechanistic insight into the pathophysiological function of FOXN3.
|
28805661 |
2017 |
|
Triple Negative Breast Neoplasms
|
0.040 |
Biomarker
|
disease |
BEFREE |
These results demonstrate a critical role for a complex containing SIN3A and PF1 in TNBC and provide a rational for its therapeutic targeting.
|
26460951 |
2015 |
|
Triple Negative Breast Neoplasms
|
0.040 |
Biomarker
|
disease |
BEFREE |
We next show that BCL11A(2-16) pulls down RBBP4, RBBP7, and other components of PRC2, NuRD, and SIN3A from the cell lysate of the TNBC cell line SUM149.
|
29263092 |
2018 |
|
Triple Negative Breast Neoplasms
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
These data sets indicated that high mRNA expression of SIN3A as well as low mRNA expression of SIN3B correlates with longer relapse free survival specifically in patients with triple negative breast cancer which corresponds with our in vitro and in vivo data.
|
27780928 |
2016 |
|
Triple Negative Breast Neoplasms
|
0.040 |
Biomarker
|
disease |
BEFREE |
We reported that the selective inhibition of the PAH2 domain of SIN3A protein function markedly suppressed metastatic dissemination to the lungs in TNBC xenograft bearing mice.
|
29179446 |
2017 |
|
Triple-Negative Breast Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
We reported that the selective inhibition of the PAH2 domain of SIN3A protein function markedly suppressed metastatic dissemination to the lungs in TNBC xenograft bearing mice.
|
29179446 |
2017 |
|
Triple-Negative Breast Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
We next show that BCL11A(2-16) pulls down RBBP4, RBBP7, and other components of PRC2, NuRD, and SIN3A from the cell lysate of the TNBC cell line SUM149.
|
29263092 |
2018 |