Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.300 GeneticVariation disease BEFREE Preventing the increase in GAPDH-SNO abundance in both cultured neurons and mice, either by overexpression of the nitrosylation mutant of GAPDH (GAPDH C150S) or by treatment with the GAPDH nitrosylation inhibitor CGP3466B (also known as omigapil), abrogated Aβ<sub>1-42</sub>-induced tau acetylation, memory impairment, and locomotor dysfunction in mice, suggesting that this drug might be repurposed to treat patients with AD. 29559585 2018
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.300 Biomarker disease BEFREE Also the role of GAPDH in neurodegenerative diseases is linked to it directly binding to specific amyloidogenic proteins and petides such as β-amyloid precursor protein, β-amyloid peptide and tau protein in Alzheimer's disease, huntingtin in Huntington's disease and α-synuclein in Parkinson disease. 30254002 2018
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.300 Biomarker disease BEFREE Neuroproteomics studies have showed the high affinity interactions between GAPDH - β-amyloid in Alzheimer disease. 28087189 2017
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.300 Biomarker disease BEFREE Our study adds new insight to previous ones by showing the involvement of GAPDH in AD, which may influence the pathogenesis of this neurodegenerative disease. 25022884 2014
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.300 Biomarker disease BEFREE Clusterin mRNA levels were unchanged when normalized to GAPDH but modestly increased in the frontal and temporal cortex in AD in relation to NSE and MAP-2. 22232000 2012
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.300 AlteredExpression disease BEFREE Picalm mRNA was elevated in relation to glyceraldehyde-3-phosphate dehydrogenase but not factor VIII-related antigen or CD31 mRNA in the frontal cortex in AD. 20838239 2010
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.300 Biomarker disease BEFREE Frequently used housekeepers such as glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and β-actin had lower overall expression in AD and AD/LBD cases than in controls. 21044776 2010
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.300 GeneticVariation disease BEFREE When the two family datasets were examined, none of the SNPs were significant in NE families, but two SNPs were associated with AD in Caribbean Hispanics: rs740850 in NCAPD2 (p = 0.0097) and rs1060620 in GAPDH (p = 0.042). 18340469 2008
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.300 AlteredExpression disease BEFREE Therefore, we studied the specific activity of GAPDH in the different animal models of AD: transgenic mice (Tg2576) and rats treated with beta-amyloid, or thiorphan, or lipopolysaccharides (LPS) and interferon gamma (INFgamma). 17324518 2007
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.300 Biomarker disease LHGDN An increase in S-glutathionylated proteins in the Alzheimer's disease inferior parietal lobule, a proteomics approach. 17387692 2007
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.300 Biomarker disease RGD Therefore, we studied the specific activity of GAPDH in the different animal models of AD: transgenic mice (Tg2576) and rats treated with beta-amyloid, or thiorphan, or lipopolysaccharides (LPS) and interferon gamma (INFgamma). 17324518 2007
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.300 AlteredExpression disease LHGDN Therefore, we studied the specific activity of GAPDH in the different animal models of AD: transgenic mice (Tg2576) and rats treated with beta-amyloid, or thiorphan, or lipopolysaccharides (LPS) and interferon gamma (INFgamma). 17324518 2007
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.300 Biomarker disease LHGDN Exploring the association of glyceraldehyde-3-phosphate dehydrogenase gene and Alzheimer disease. 16832079 2006
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.300 Biomarker disease BEFREE Exploring the association of glyceraldehyde-3-phosphate dehydrogenase gene and Alzheimer disease. 16832079 2006
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.300 Biomarker disease LHGDN Our findings suggest that disulfide bonding of GAPDH and subsequent protein aggregate formation may have relevance to the pathophysiology of AD. 16186172 2005
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.300 GeneticVariation disease LHGDN Our observations raise the possibility that GAPD genes are AD risk factors, a hypothesis that is consistent with the role of GAPD in neuronal apoptosis. 15507493 2004
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.300 Biomarker disease BEFREE These findings suggest that GAPDH can be used as a endogenous reference gene in the study of AD brains. 14687679 2004
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.300 Biomarker disease BEFREE Our observations raise the possibility that GAPD genes are AD risk factors, a hypothesis that is consistent with the role of GAPD in neuronal apoptosis. 15507493 2004
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.300 Biomarker disease BEFREE Interestingly, immunocytochemical examination of human post-mortem materials from patients with Alzheimer's disease revealed nuclear aggregated GAPDH in neurons of the affected brain regions, implying an association with apoptotic cell death. 15094325 2004
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.300 Biomarker disease BEFREE To assess the importance of potential confounders TaqMan real-time RT-PCR was used to measure seven mRNAs (beta-actin, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), cyclophilin, microtubule-associated protein (MAP) 2, neuron-specific enolase (NSE), glial fibrillary acidic protein (GFAP), amyloid precursor protein (APP) isoform 770) in cortical samples taken from 90 Alzheimer's disease (AD) and 81 control brains. 14559355 2003
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.300 AlteredExpression disease BEFREE Our recent findings (Mazzola and Sirover, 2001) demonstrate a subcellular reduction in GAPDH glycolytic activity in Alzheimer's disease (AD) and in Huntington's disease (HD) cells. 12428732 2002
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.300 AlteredExpression disease BEFREE Brain GAPDH activity was normal in all groups with the exception of a slight but statistically significant region-specific reduction in the patients with Huntington disease (caudate nucleus, -12%) and Alzheimer disease (temporal cortex, -19%). 9779656 1998
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.300 Biomarker disease BEFREE The possible localization of Gapdh on MMU16--which may provide a mouse model for Down's syndrome and Alzheimer's disease--may lead to new insights into glycolysis and its role in the two syndromes. 7891898 1994