|
TREMOR, HEREDITARY ESSENTIAL, 5
|
0.600 |
GeneticVariation
|
disease |
UNIPROT |
Missense mutations in TENM4, a regulator of axon guidance and central myelination, cause essential tremor.
|
26188006 |
2015 |
|
TREMOR, HEREDITARY ESSENTIAL, 5
|
0.600 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
TREMOR, HEREDITARY ESSENTIAL, 5
|
0.600 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Bipolar Disorder
|
0.450 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study identifies two novel susceptibility loci and trans population polygenicity associated with bipolar disorder.
|
28115744 |
2018 |
|
Bipolar Disorder
|
0.450 |
GeneticVariation
|
disease |
BEFREE |
A subsequent meta-analysis of Phase I/II and the Psychiatric GWAS Consortium for BD (PGC-BD) identified another novel BD gene, NFIX (P<sub>best</sub>=5.8 × 10<sup>-10</sup>), and supported three regions previously implicated in BD susceptibility: MAD1L1 (P<sub>best</sub>=1.9 × 10<sup>-9</sup>), TRANK1 (P<sub>best</sub>=2.1 × 10<sup>-9</sup>) and ODZ4 (P<sub>best</sub>=3.3 × 10<sup>-9</sup>).
|
28115744 |
2018 |
|
Bipolar Disorder
|
0.450 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study reveals two new risk loci for bipolar disorder.
|
24618891 |
2014 |
|
Bipolar Disorder
|
0.450 |
GeneticVariation
|
disease |
BEFREE |
Genotyping of five genome-wide significant variants identified for BD (in CACNA1C, ANK3, and ODZ4) was performed in 673 BPD cases and 748 controls.
|
25304227 |
2014 |
|
Bipolar Disorder
|
0.450 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study reveals two new risk loci for bipolar disorder.
|
24618891 |
2014 |
|
Bipolar Disorder
|
0.450 |
GeneticVariation
|
disease |
GWASCAT |
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
|
23453885 |
2013 |
|
Bipolar Disorder
|
0.450 |
GeneticVariation
|
disease |
BEFREE |
Our data provide support for two regions, at ODZ4 and CACNA1C, with prior evidence for genome-wide significant (GWS) association in PGC-BD meta-analysis.
|
23070075 |
2013 |
|
Bipolar Disorder
|
0.450 |
GeneticVariation
|
disease |
GWASDB |
Replication of bipolar disorder susceptibility alleles and identification of two novel genome-wide significant associations in a new bipolar disorder case-control sample.
|
23070075 |
2013 |
|
Bipolar Disorder
|
0.450 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder.
|
22182935 |
2013 |
|
Bipolar Disorder
|
0.450 |
Biomarker
|
disease |
BEFREE |
In addition to pathway enrichment, the collective network approach elevates the importance of ANK3, DGKH and ODZ4 for BD susceptibility in the WTCCC GWAS, despite their weak single-locus effect in the data.
|
22892719 |
2012 |
|
Bipolar Disorder
|
0.450 |
GeneticVariation
|
disease |
GWASDB |
An analysis of all 11,974 bipolar disorder cases and 51,792 controls confirmed genome-wide significant evidence of association for CACNA1C and identified a new intronic variant in ODZ4.
|
21926972 |
2011 |
|
Bipolar Disorder
|
0.450 |
GeneticVariation
|
disease |
GWASCAT |
An analysis of all 11,974 bipolar disorder cases and 51,792 controls confirmed genome-wide significant evidence of association for CACNA1C and identified a new intronic variant in ODZ4.
|
21926972 |
2011 |
|
Bipolar Disorder
|
0.450 |
Biomarker
|
disease |
CTD_human |
An analysis of all 11,974 bipolar disorder cases and 51,792 controls confirmed genome-wide significant evidence of association for CACNA1C and identified a new intronic variant in ODZ4.
|
21926972 |
2011 |
|
Bipolar Disorder
|
0.450 |
GeneticVariation
|
disease |
BEFREE |
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
|
21926972 |
2011 |
|
Schizophrenia
|
0.420 |
GeneticVariation
|
disease |
BEFREE |
We herein performed exome sequencing in a Han Chinese schizophrenia family and identified a missense mutation (c.6724C>T, p.R2242C) in the teneurin transmembrane protein 4 (<i>TENM4</i>) gene in the SCZD2 locus, a region previously linked to schizophrenia at 11q14-21.
|
30745909 |
2018 |
|
Schizophrenia
|
0.420 |
Biomarker
|
disease |
PSYGENET |
Our findings show ODZ4 as a risk gene for SCZ, emphasizing the existence of common vulnerability in psychosis.
|
25124521 |
2014 |
|
Schizophrenia
|
0.420 |
Biomarker
|
disease |
BEFREE |
Our findings show ODZ4 as a risk gene for SCZ, emphasizing the existence of common vulnerability in psychosis.
|
25124521 |
2014 |
|
Schizophrenia
|
0.420 |
GeneticVariation
|
disease |
GWASCAT |
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
|
23453885 |
2013 |
|
Psychotic Disorders
|
0.310 |
Biomarker
|
group |
PSYGENET |
Our findings show ODZ4 as a risk gene for SCZ, emphasizing the existence of common vulnerability in psychosis.
|
25124521 |
2014 |
|
Psychotic Disorders
|
0.310 |
Biomarker
|
group |
BEFREE |
Our findings show ODZ4 as a risk gene for SCZ, emphasizing the existence of common vulnerability in psychosis.
|
25124521 |
2014 |
|
Nonorganic psychosis
|
0.310 |
Biomarker
|
disease |
PSYGENET |
Our findings show ODZ4 as a risk gene for SCZ, emphasizing the existence of common vulnerability in psychosis.
|
25124521 |
2014 |
|
Nonorganic psychosis
|
0.310 |
Biomarker
|
disease |
BEFREE |
Our findings show ODZ4 as a risk gene for SCZ, emphasizing the existence of common vulnerability in psychosis.
|
25124521 |
2014 |