TENM4, teneurin transmembrane protein 4, 26011

N. diseases: 44; N. variants: 52
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0270736
Disease: Essential Tremor
Essential Tremor
0.030 Biomarker disease BEFREE The coding portion of teneurin transmembrane protein 4 was sequenced in 269 unrelated essential tremor cases and 288 matched control individuals using a targeted and high-throughput sequencing approach. 28158909 2017
CUI: C0270736
Disease: Essential Tremor
Essential Tremor
0.030 Biomarker disease BEFREE Recent discoveries linking LINGO1, FUS and TENM4 to essential tremor have been met with cautious optimism since reproducibility and pathogenicity have been contentious in previously implicated genes. 26411503 2016
CUI: C0270736
Disease: Essential Tremor
Essential Tremor
0.030 GeneticVariation disease BEFREE Whole-exome sequencing revealed a missense mutation in TENM4 segregating in an autosomal-dominant fashion in an ET family. 26188006 2015