Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.400 AlteredExpression disease BEFREE We found seven miRNAs that significantly downregulated CHD5 expression in NB: miR-211, 17, -93, -20b, -106b, -204, and -3666. 26895110 2016
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.400 Biomarker disease CTD_human Recurrent alterations at relapse included mutations in the putative CHD5 neuroblastoma tumor suppressor, chromosome 9p losses, DOCK8 mutations, inactivating mutations in PTPN14 and a relapse-specific activity pattern for the PTPN14 target YAP. 26121086 2015
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.400 GeneticVariation disease BEFREE Recurrent alterations at relapse included mutations in the putative CHD5 neuroblastoma tumor suppressor, chromosome 9p losses, DOCK8 mutations, inactivating mutations in PTPN14 and a relapse-specific activity pattern for the PTPN14 target YAP. 26121086 2015
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.400 AlteredExpression disease BEFREE We explored the role of CHD5 expression in the neuronal differentiation of NB cell lines. 26245651 2015
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.400 AlteredExpression disease BEFREE Furthermore, low CHD5 expression is strongly associated with unfavorable clinical and biologic features as well as outcome in neuroblastomas and many other tumor types. 24419087 2014
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.400 AlteredExpression disease BEFREE Reintroduction of CHD5 into neuroblastoma cells represses WEE1 expression, demonstrating that CHD5 can function as a repressor in cells. 25247294 2014
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.400 AlteredExpression disease BEFREE These findings provide insights into the regulatory role of CHD5 during neurogenesis and suggest how inactivation of this candidate tumor suppressor might contribute to neuroblastoma. 23948251 2013
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.400 Biomarker disease BEFREE Unlike wild-type Chd5, Chd5-PHD mutants are unable to induce differentiation or efficiently suppress the growth of human neuroblastoma in vivo. 23318260 2013
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.400 PosttranslationalModification disease BEFREE We conclude that (i) somatically acquired CHD5 mutations are rare in primary NBs, so inactivation probably occurs by deletion and epigenetic silencing; (ii) CHD5 expression and promoter methylation are associated with MYCN amplification, suggesting a possible interaction between these 2 genes; and (iii) high CHD5 expression is strongly correlated with favorable clinical/biological features and outcome. 22294723 2012
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.400 AlteredExpression disease BEFREE In the present study, our results showed that genistein, an element found in soy, is an epigenetic modifier able to decrease hypermethylation levels of CHD5, and enhances the expression of CHD5 as well as p53, possibly contributing to inhibition of NB growth in vivo and tumor microvessel formation. 22960751 2012
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.400 Biomarker disease BEFREE Expression of the neuron-specific protein CHD5 is an independent marker of outcome in neuroblastoma. 20950435 2010
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.400 Biomarker disease BEFREE Among the best candidate genes predisposing to the development of neuroblastoma located in 1p36, the AJAP1 gene is the only gene present in the duplication while CHD5, TNFRSF25 and CAMTA1 are located outside of the rearrangement. 18672103 2009
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.400 Biomarker disease BEFREE Our mutation and expression analysis in neuroblastoma cell lines, combined with expression analysis in normal tissues, putative function and prior implication in neuroblastoma pathogenesis, suggests that the most promising TSG deleted from the 1p36 SRD is CHD5, but TNFRSF25, CAMTA1 and AJAP1 are also viable candidates. 17667943 2008
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.400 AlteredExpression disease BEFREE CHD5 expression was very low or absent in neuroblastoma cell lines. 18577749 2008
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.400 AlteredExpression disease BEFREE We examined a panel of neuroblastoma cell lines for CHD5 expression, which was consistently low or undetectable in all these lines. 12592387 2003
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.340 PosttranslationalModification disease BEFREE Thus, it can be concluded that the CHD5 methylation rate rises gradually in the evolution of CRC, which is related to the occurrence and development of CRC. 26753653 2016
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.340 PosttranslationalModification disease BEFREE The epigenetic silencing mechanisms of CHD5 in colorectal cancer have not been well studied. 24243398 2014
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.340 AlteredExpression disease BEFREE Our previous work revealed that the low expression of CHD5 in colorectal cancer is correlated with CHD5 promoter CpG island hypermethylation. 22235338 2012
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.340 Biomarker disease CTD_human Genomic and epigenomic integration identifies a prognostic signature in colon cancer. 21278247 2011
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.340 PosttranslationalModification disease BEFREE We investigated the status of CAN gene methylation and CHD5 protein expression in African American CRC tissue microarrays (TMA) using immunohistochemical staining. 19750230 2009
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.320 AlteredExpression disease BEFREE CHD5 protein expression was also reduced in breast cancer, and lack of CHD5 expression significantly correlated with higher tumor stage, ER/PR-negativity, HER2 positivity, distant metastasis and worse patient survival (P ≤ 0.01). 22569290 2012
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.320 GeneticVariation disease BEFREE We analyzed all 41 coding exons of CHD5 for somatic mutations in 123 primary ovarian cancers as well as 60 primary breast cancers using high-resolution melt analysis. 18953434 2008
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.320 GeneticVariation disease UNIPROT
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.300 Biomarker group CTD_human Genomic and epigenomic integration identifies a prognostic signature in colon cancer. 21278247 2011
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 GeneticVariation group BEFREE rs187960998 in miR-211 was highly associated with a decreased risk of CC in the Chinese population by deregulating a tumor suppressive gene CHD5. 30655677 2019