Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.050 GeneticVariation disease BEFREE Our results suggest that the rare CHD5 gene haplotype and alcohol intake contribute to the risk of HCC. 29907144 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.050 Biomarker disease BEFREE These findings uncovered, for the first time, a mutual suppression regulation between CHD5 and EZH2, which may provide new insights into their potential therapeutic significance for HCC. 26517514 2015
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.050 Biomarker disease BEFREE miR-454 functions as an oncogene by inhibiting CHD5 in hepatocellular carcinoma. 26287602 2015
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.050 AlteredExpression disease BEFREE In the present study, we report a novel insulin-like growth factor 1 (IGF1) pathway that mediates de novo DNA methylation and TSG (such as DLC1 and CHD5) silencing by upregulation of the DNA methyltransferase 1 (DNMT1) via an AKT/β-transducin repeat-containing protein (βTrCP)-mediated ubiquitin-proteasome pathway in HCC. 25420499 2015
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.050 AlteredExpression disease BEFREE CHD5 expression was sinificantly down-regulated in HCC cell lines and tissues examined, and the -841 to -470 region of CHD5 promoter was hypermethylated in these samples. 24529164 2014