|
Neurodevelopmental Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
These terminal events impact IGF1R, CNTNAP2, and DPP6, shown to be strongly associated with neurodevelopmental disorders.
|
31475484 |
2019 |
|
Neurodevelopmental Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Although the mechanism underlying this gender difference remains unknown, the contactin-associated protein-like 2 (CNTNAP2) gene, which shows sex-specific patterns in some neurodevelopmental disorders, has attracted extensive attention.
|
30017804 |
2018 |
|
Neurodevelopmental Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Contactin associated protein-like 2 (CNTNAP2) has emerged as a prominent susceptibility gene implicated in multiple complex neurodevelopmental disorders, including autism spectrum disorders (ASD), intellectual disability (ID), and schizophrenia (SCZ).
|
29610457 |
2018 |
|
Neurodevelopmental Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
In line with a role of CASPR2 in the mature nervous system, neurological autoimmune diseases have been described in patients without neurodevelopmental disorders but with antibodies directed against CASPR2.
|
30028556 |
2018 |
|
Neurodevelopmental Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
These findings reveal a key contribution of ASD-associated gene CNTNAP2 in modulating macroscale functional connectivity, and suggest that homozygous loss-of-function mutations in this gene may predispose to neurodevelopmental disorders and autism through a selective dysregulation of connectivity in integrative prefrontal areas.
|
28184409 |
2018 |
|
Neurodevelopmental Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings complement the known roles of CASPR2 in brain development, and warrant further epidemiological and experimental studies to clarify the role of CASPR2 and possibly other antibodies in neurodevelopmental disorders.
|
28572274 |
2017 |
|
Neurodevelopmental Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results point in the direction that CNTNAP2 may not play a major role in HFA, but rather seems to have a significance in neurodevelopmental disorders or in individuals displaying intellectual delays.
|
26559825 |
2016 |
|
Neurodevelopmental Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
CNTNAP2, one of the largest genes in the human genome, has been linked to human-specific language abilities and neurodevelopmental disorders.
|
24434791 |
2014 |
|
Neurodevelopmental Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Neurobiological, genetic, and imaging data provide strong evidence for the CNTNAP2 gene as a risk factor for ASD and related neurodevelopmental disorders.
|
22365836 |
2012 |
|
Neurodevelopmental Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Here, we characterize a mouse knockout of the Cntnap2 gene, which is strongly associated with ASD and allied neurodevelopmental disorders.
|
21962519 |
2011 |
|
Neurodevelopmental Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Common variants in contactin-associated protein-like 2 (CNTNAP2), a neurexin superfamily member, have been associated with several allied neurodevelopmental disorders, including autism and specific language impairment, and CNTNAP2 is highly expressed in frontal lobe circuits in the developing human brain.
|
21048216 |
2010 |