LRRC32, leucine rich repeat containing 32, 2615

N. diseases: 58; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0013595
Disease: Eczema
Eczema
0.040 GeneticVariation disease BEFREE A risk locus on chromosome 11q13.5 lies between 2 candidate genes, EMSY and LRRC32 (leucine-rich repeat-containing 32) but the functional mechanisms affecting risk of AD remain unclear. 31158401 2019
CUI: C0013595
Disease: Eczema
Eczema
0.040 Biomarker disease BEFREE Atopic Dermatitis According to GARP: New Mechanistic Insights in Disease Pathogenesis. 27884290 2016
CUI: C0013595
Disease: Eczema
Eczema
0.040 GeneticVariation disease BEFREE Subsequent association testing in more than 2,000 atopic dermatitis patients and 2,000 control subjects showed a significant excess of these LRRC32 variants in individuals with atopic dermatitis. 27448748 2016
CUI: C0013595
Disease: Eczema
Eczema
0.040 GeneticVariation disease BEFREE Variants in a locus near chromosome 11 open reading frame 30 (C11orf30) and leucine-rich repeat containing 32 (LRRC32), which was previously associated with atopic dermatitis and eczema, were also strongly associated with both phenotypes (rs2155219; P(grass) = 9.4 × 10(-9); P(AR) = 3.8 × 10(-8)). 22036096 2011