LRRC32, leucine rich repeat containing 32, 2615

N. diseases: 58; N. variants: 3
Disease: melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.030 Biomarker disease BEFREE GARP has been recently observed in only a few solid tumors including breast, colon, lung cancers, and melanoma. 30443770 2019
CUI: C0025202
Disease: melanoma
melanoma 		0.030 GeneticVariation disease BEFREE Platelet-specific deletion of the GARP-encoding gene <i>Lrrc32</i> blunted TGFβ activity at the tumor site and potentiated protective immunity against both melanoma and colon cancer. 28763790 2017
CUI: C0025202
Disease: melanoma
melanoma 		0.030 AlteredExpression disease BEFREE Herein, suppressive immune cells and inhibitory factors secreted by the tumor itself play a central role.In the present study we show that the Treg activation marker GARP (glycoprotein A repetitions predominant), known to induce peripheral tolerance in a TGF-β dependent way, is also expressed on human primary melanoma. 27248166 2016