|
leukemia
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
In summary, reduction of Gata2 activity affects mutational dynamics of leukemia with delayed leukemia onset in Cbfb-MYH11 knockin mice, but paradoxically results in a more aggressive leukemia phenotype, which may be correlated with leukemia relapse or poor prognosis in human patients.
|
31624376 |
2020 |
|
leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Various heteroallelic GATA2 gene mutations are associated with a variety of hematological neoplasms, including myelodysplastic syndromes and leukemias.
|
30710465 |
2019 |
|
leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
GATA-2 mutations are associated with immunodeficiency, lymphedema, myelodysplastic syndrome (MDS), and leukemia.
|
28566565 |
2017 |
|
leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
GATA2 mutations are associated with several conditions, including Emberger syndrome which is the association of primary lymphedema with hematological anomalies and an increased risk for myelodysplasia and leukemia.
|
28271814 |
2017 |
|
leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Hematopoietic development requires the transcription factor GATA-2, and GATA-2 mutations cause diverse pathologies, including leukemia.
|
28930689 |
2017 |
|
leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Transcription factor gene GATA2: Association of leukemia and nonsynonymous to the synonymous substitution rate across five mammals.
|
26850985 |
2016 |
|
leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia.
|
24703711 |
2014 |
|
leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
Mutations in the master regulator of hematopoiesis GATA-2 underlie an immunodeficiency associated with myelodysplastic syndrome and leukemia.
|
25056917 |
2014 |
|
leukemia
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
We found a significant correlation among the amounts of WT1, GATA-1 and GATA-2 mRNAs from leukemia and solid tumor cell lines.
|
19212333 |
2009 |
|
leukemia
|
0.200 |
Biomarker
|
disease |
LHGDN |
Interactions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and the t(11;17)-generated PLZF-retinoic acid receptor alpha oncoprotein.
|
11964310 |
2002 |
|
leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
GATA-2 was detectable in all the cases of primary leukemias examined in this study, except one case of M5.
|
9808054 |
1998 |
|
leukemia
|
0.200 |
Biomarker
|
disease |
HPO |
|
|
|