|
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We found no evidence of association between FGF20 variability and PD risk, and no relationship between the rs12720208 genotype, FGF20 and alpha-synuclein protein levels.
|
19133659 |
2009 |
|
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Taken together, these findings suggest that common genetic variants in FGF20 are not a risk factor for PD in, at least, some European populations.
|
15967032 |
2005 |
|
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation in fibroblast growth factor 20 (FGF20) might influence the risk of PD occurrence and development.
|
22342445 |
2012 |
|
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Variation in the miRNA-433 binding site of FGF20 is a risk factor for Parkinson's disease in Iranian population.
|
26070653 |
2015 |
|
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Variants in the fibroblast growth factor 20 gene (FGF20) have been reported to be associated with the risk of Parkinson's disease.
|
27040428 |
2016 |
|
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
In a cell-based system and in PD brains, this increase in translation of FGF20 is correlated with increased alpha-synuclein expression, which has previously been shown to cause PD through both overexpression and point mutations.
|
18252210 |
2008 |
|
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To evaluate the relationships among 3 polymorphic markers located in the fibroblast growth factor 20 and transmembrane protein 175 genes and the genetic susceptibility to PD in northern Chinese subjects, 2 single nucleotide polymorphisms, and 1 insertion/deletion marker (rs591323 in FGF20; rs6599388 and rs142821586 in transmembrane protein 175 near the G-associated kinase/diacylglycerol kinase theta region) were investigated in 313 PD patients and 318 matched controls.
|
26535683 |
2015 |
|
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, variants in FGF20 and MAOB show evidence of statistical interactions, which emphasizes the importance of considering them jointly in genetic analysis of PD and illustrates potential patterns of biological interaction contributing to PD risk.
|
18205889 |
2008 |
|
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The pooled odds ratio (OR) with its 95 % confidence interval (CI) was calculated to assess the genetic association between FGF20 rs12720208 polymorphism and the risk of PD.
|
27023076 |
2016 |
|
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The meta-analysis showed an association between FGF20 gene rs1721100 polymorphism and risk of Parkinson's disease under a recessive model (GG versus CG+GG; OR = 1.15, 95 % CI 1.02-1.29, p = 0.02) but not under a dominant model (CG+GG versus CC; OR = 1.03, 95 % CI 0.93-1.13, p = 0.57).
|
24942208 |
2014 |
|
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The pooled odds ratios (OR) and 95% confidence interval (CI) were calculated to assess the association between FGF20 rs12720208 polymorphism and PD risk.
|
28191856 |
2017 |
|
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
FGF20 rs12720208 SNP and microRNA-433 variation: no association with Parkinson's disease in Spanish patients.
|
20471450 |
2010 |
|
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Our results strongly support FGF20 as a risk factor for PD.
|
15122513 |
2004 |
|
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
In conclusion, variants in FGF20 and MAOB show evidence of statistical interactions, which emphasizes the importance of considering them jointly in genetic analysis of PD and illustrates potential patterns of biological interaction contributing to PD risk.
|
18205889 |
2008 |
|
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our study is the first to demonstrate that FGF20 (rs591323) is associated with a lower risk of PD in a Southern Han Chinese population from mainland China.
|
28238162 |
2017 |
|
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This indicates the FGF20 gene might not play a major role in the genetic predisposition to PD in this population.
|
23938014 |
2013 |
|
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We explored the effect of single-nucleotide polymorphisms (SNPs) in the fibroblast growth factor 20 gene (FGF20) associated with risk for Parkinson's disease on brain structure and function in a large sample of healthy young-adult human subjects and also in elderly subjects to look at the interaction between genetic variations and age (N = 237; 116 men; 18-87 years).
|
20427658 |
2010 |
|
Depressive Symptoms
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
A statistically significant association of the functional polymorphism in the FGF20 gene (rs12720208) with depressive symptoms was found.
|
30241547 |
2018 |
|
Essential Tremor
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The findings indicate the FGF20 gene might not play a dominating role in the genetic predisposition to ET in Chinese Han population.
|
27040428 |
2016 |
|
Class III malocclusion
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We also identified 3 variants: rs13317 in FGFR1, rs149242678 in FGF20, and rs79176051 FGF12 associated with MP (P < .05).
|
28640125 |
2017 |
|
Sporadic Parkinson disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Fibroblast growth factor 20 polymorphism in sporadic Parkinson's disease in Northern Han Chinese.
|
23938014 |
2013 |
|
Congenital absence of kidneys syndrome
|
0.400 |
Biomarker
|
disease |
HPO |
|
|
|
|
RENAL HYPODYSPLASIA/APLASIA 2
|
0.400 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man.
|
22698282 |
2012 |
|
RENAL HYPODYSPLASIA/APLASIA 2
|
0.400 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man.
|
22698282 |
2012 |
|
Bipolar Disorder
|
0.300 |
Biomarker
|
disease |
PSYGENET |
Molecular genetics and developmental studies have identified 21 genes in this region (ADRA1A, ARHGEF10, CHRNA2, CHRNA6, CHRNB3, DKK4, DPYSL2, EGR3, FGF17, FGF20, FGFR1, FZD3, LDL, NAT2, NEF3, NRG1, PCM1, PLAT, PPP3CC, SFRP1 and VMAT1/SLC18A1) that are most likely to contribute to neuropsychiatric disorders (schizophrenia, autism, bipolar disorder and depression), neurodegenerative disorders (Parkinson's and Alzheimer's disease) and cancer.
|
19204725 |
2009 |