Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Tumor expression of glucagon and somatostatin receptor subtype 2 and 3 messenger RNA was markedly upregulated.
|
29688432 |
2018 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
GLP-1 levels significantly increased after surgery (149.96 ± 31.25 vs 220.23 ± 27.55) (P < 0.05), while GIP levels decreased but not significantly. p53 gene expression significantly increased in the duodenal mucosa (P < 0.05, 2.06 fold) whereas the tumor growth factor-β gene expression significantly increased (P < 0.05, 2.52 fold) in the ileal mucosa after surgery.
|
26078577 |
2015 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
GLP-2(1-33) treatment in animals with a pre-induced cancer showed that GLP-2(1-33) may promote growth of existing neoplasia.
|
29231791 |
2018 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Glucagon-like-peptide-1 (GLP) receptor analogs are the latest agents being used in the detection of insulinomas, with initial reports suggesting high sensitivity due to universal GLP1 receptor expression on these tumors.
|
29877881 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
GLP-1 analogue exendin-4, a glucagon-like peptide 1 receptor (GLP-1R) agonist which shares 53% sequence with GLP-1, plays an essential role in human tumors.
|
30119208 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
All tumors were positive for panendocrine immunohistochemistry markers (chromogranin A and/or synaptophysin); 35% of NETs demonstrated focal positivity for pancreatic polypeptide, somatostatin, insulin, and/or glucagon; and no immunostaining for pancreatic and gastrointestinal hormones was observed in 65% of tumors.
|
9665483 |
1998 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
And the AAA and the GCG haplotypes also respectively have significant influences on tumor size and ER status.
|
19903360 |
2009 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
At ≤20°C, glp-1(ar202) is wild-type, whereas at 25°C it forms a germline stem cell⁄progenitor cell tumor reminiscent of human cancer.
|
26120834 |
2015 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
By analyses of RNA transcripts and immunoreactive peptides in four human insulinomas and one glucagonoma, we found that the insulin, somatostatin, and glucagon genes were coexpressed in all tumors.
|
2903836 |
1988 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Considering tumor heterogeneity, the percentage of ALK amplified tumor cells ranged from 11% to 43%, with a mean gene copy gain (GCG ± SD) of 6.9 ± 0.8 and no signal differences between the epithelial (6.5 ± 0.9) and the sarcoma-like components (6.8 ± 0.9) of tumors.
|
22705117 |
2012 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Expression of multiple hormones such as gastrin, insulin, pancreatic polypeptide and somatostatin was also observed throughout the neoplastic cell population, while the endocrine component of the neoplasm was predominantly positive for glucagon.
|
30898297 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
However, hyperglucagonemia is also observed in other clinical conditions than diabetes, including nonalcoholic fatty liver disease, glucagon-producing tumors and after gastric bypass surgery.
|
27611762 |
2016 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Hypercalcemia in Glucagon Cell Hyperplasia and Neoplasia (Mahvash Syndrome): A New Association.
|
30032256 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Immnohistochemical staining of tumor tissue was positive for glucagon.
|
31517863 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In patients with glucagon-producing tumors (glucagonomas), the most conspicuous signs are skin lesions (necrolytic migratory erythema), while in subjects with inactivating mutations of the glucagon receptor, pancreatic swelling may be the first sign; neither condition is necessarily associated with disturbed glucose metabolism.
|
28108603 |
2017 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
No mutations were observed in the cytoplasmic domains of the TSH-R, except for a neutral base substitution in codon 460 (GCG [Ala]-->GCA [Ala]) in 3 tumors, which was also present in constitutional DNA from the affected individuals.
|
8501149 |
1993 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Silent polymorphisms at codon 11 (CCC --> CCT; Pro --> Pro) and codon 75 (GCG --> GCA; Ala --> Ala) were frequently detected in tumors as well as in normal tissues.
|
12699056 |
2003 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The tumor cells were positive for immunoreactive insulin and glucagon.
|
9438006 |
1997 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The importance of the GLP-2R for tumor growth was also examined in Apc(Min/+) mice chronically treated with exogenous GLP-2 and in Apc(Min/+):Glp2r(-/-) mice.
|
18829546 |
2008 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The majority of these tumor cells were immunohistochemically positive for insulin and negative for glucagon.
|
19350420 |
2009 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The nature of selective hyper-expression of HMG-17 in glucagon but not in insulin-producing tumor tissue remains to be clarified.
|
2169420 |
1990 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The other patients were nonsymptomatic and showed multiple glucagon-expressing neoplasms.
|
16699310 |
2006 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The pluripotent rat islet tumor cell line MSL-G2 expresses primarily glucagon or cholecystokinin and not insulin in vitro but changes phenotype completely after prolonged in vivo cultivation to yield small-sized hypoglycemic tumors composed almost entirely of insulin-producing beta cells.
|
2842785 |
1988 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The rate constant for baseline catecholamine secretion was 20-fold higher in VHL than in MEN 2 tumors (0.359 +/- 0.094 vs. 0.018 +/- 0.009 day(-1)), but catecholamine release was responsive only to glucagon in MEN 2 tumors.
|
18854424 |
2008 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The workup of the patient revealed a tumor localized in the head of the pancreas, and glucagon serum levels were elevated.
|
30124507 |
2019 |