GCG, glucagon, 2641

N. diseases: 441; N. variants: 10
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003123
Disease: Anorexia
Anorexia
0.380 Biomarker disease BEFREE The interaction between serotonin (5-HT) and glucagon-like peptide-1 (GLP-1) could play a role as upstream effectors involved in mediating associations between anorectic and noxious/stressful stimuli. 30959513 2019
CUI: C0003123
Disease: Anorexia
Anorexia
0.380 Biomarker disease BEFREE Here, we investigated if peripheral co-administration of ADM and glucagon-like peptide 1 (GLP-1) could subdue the hypoglycaemic effects of ADM while enhancing its anorectic properties. 30396073 2019
CUI: C0003123
Disease: Anorexia
Anorexia
0.380 Biomarker disease BEFREE This molecule combined the beneficial anorectic and glycemic effects of glucagon-like peptide 1 with the thermogenic effect of glucagon into a single molecule with enhanced potency and sustained action. 30087160 2018
CUI: C0003123
Disease: Anorexia
Anorexia
0.380 Biomarker disease BEFREE Given the role of GLP-1 as a mediator of anorexia under acute sickness conditions, we hypothesized that brainstem GLP-1 signalling might play a role in the mediation of CACS. 29247677 2018
CUI: C0003123
Disease: Anorexia
Anorexia
0.380 Biomarker disease BEFREE Taken together, our findings suggest that both GLP-1 and CCK play contributory roles in T-2 toxin-induced anorexia. 29433086 2018
CUI: C0003123
Disease: Anorexia
Anorexia
0.380 Biomarker disease CTD_human Role of Glucagon-Like Peptide-1 and Gastric Inhibitory Peptide in Anorexia Induction Following Oral Exposure to the Trichothecene Mycotoxin Deoxynivalenol (Vomitoxin). 28633506 2017
CUI: C0003123
Disease: Anorexia
Anorexia
0.380 Biomarker disease BEFREE In conclusion, CCK plays a contributory role in anorexia induction but GLP-1 might play a lesser role in this response. 28964791 2017
CUI: C0003123
Disease: Anorexia
Anorexia
0.380 Biomarker disease BEFREE Estradiol modulates the anorexic response to central glucagon-like peptide 1. 28558993 2017
CUI: C0003123
Disease: Anorexia
Anorexia
0.380 Biomarker disease BEFREE Pretreatment with the GLP-1 receptor antagonist Exendin9-39 induced a dose-dependent attenuation of both GLP-1- and DON-induced anorexia. 28633506 2017