Hyperinsulinism
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results demonstrated that obestatin might have a potential therapeutic relevance in improving islet cell function, including increasing insulin secretion through inhibiting beta cell apoptosis and decreasing glucagon secretion by inhibiting alfa cell proliferation in type 2 diabetes.
|
30776368 |
2019 |
Hyperinsulinism
|
0.400 |
Biomarker
|
disease |
BEFREE |
In glucagon like peptide-1 (GLP-1) receptor knockout mice, Zn2+ reduced glucose by 15-28% (p < 0.05-p < 0.01) and increased insulin release by 35-43% (p < 0.01).
|
30738010 |
2019 |
Hyperinsulinism
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Moreover, significantly increased insulin and glucagon expressions were observed in the suitable induction medium, and the characteristic beta cell transcription factors Pdx1, Ngn3, and MafA were expressed at levels as high as those in pancreatic islet cells.
|
30252163 |
2019 |
Hyperinsulinism
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Older mutants (18 to 24 months) were normoglycemic, and increased insulin and glucagon expression was accompanied by a prominent increase in pancreatic islet size and β and α cell numbers.
|
31504428 |
2019 |
Hyperinsulinism
|
0.400 |
Biomarker
|
disease |
BEFREE |
Lipid-induced impairment of hepatic sensitivity, not only to insulin but potentially also to glucagon, resulting in both hyperinsulinemia and hyperglucagonemia, may therefore contribute to the development of T2D at least in a subset of individuals with NAFLD.
|
30920583 |
2019 |
Hyperinsulinism
|
0.400 |
Biomarker
|
disease |
BEFREE |
During OGTT, children with obesity and high insulin had a worse suppression of glucagon during the first 10 minutes after glucose intake.
|
31271247 |
2019 |
Hyperinsulinism
|
0.400 |
Biomarker
|
disease |
BEFREE |
Intraperitoneal administration of lamprey and paddlefish GLP-1 (25 nmol/kg body weight) in mice produced significant decreases in blood glucose and increased insulin concentrations comparable to the effects of human GLP-1.
|
30312651 |
2019 |
Hyperinsulinism
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, fenofibrate improved glucose tolerance, reduced fasting glucagon levels and prevented fasting hyperinsulinaemia.
|
31410530 |
2019 |
Hyperinsulinism
|
0.400 |
Biomarker
|
disease |
BEFREE |
Fructose Consumption Contributes to Hyperinsulinemia in Adolescents With Obesity Through a GLP-1-Mediated Mechanism.
|
30938760 |
2019 |
Hyperinsulinism
|
0.400 |
Biomarker
|
disease |
BEFREE |
Meal-induced GLP-1 secretion is as much as tenfold higher in patients after GB compared to non-surgical individuals and inhibition of GLP-1 action during meals reduces postprandial hyperinsulinemia after GB two to three times more than that in persons without surgery.
|
29113813 |
2018 |
Hyperinsulinism
|
0.400 |
Biomarker
|
disease |
BEFREE |
p8-/- mice showed no differences in glucagon or insulin content but higher insulin secretion from pancreatic islets upon glucose stimulation. p8 deficiency resulted in elevated beta cell mass but was not associated with increased insulin resistance in ipGTT or ipITT.
|
30040846 |
2018 |
Hyperinsulinism
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Increased insulin clearance in mice with double deletion of glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide receptors.
|
29351421 |
2018 |
Hyperinsulinism
|
0.400 |
Biomarker
|
disease |
BEFREE |
In particular, chymotrypsin is increased in the state of hyperinsulinemia and trypsin is significantly associated with glucagon and pancreatic polypeptide.
|
28958690 |
2018 |
Hyperinsulinism
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, we have observed that women with GDM have lower GLP-1 response at 30 min of an OGTT and hyperglycemia at 120 min despite significant hyperinsulinemia.
|
30232211 |
2018 |
Hyperinsulinism
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
PG response to glucagon declined with increasing insulin levels.
|
28922582 |
2018 |
Hyperinsulinism
|
0.400 |
Biomarker
|
disease |
BEFREE |
Circulating concentrations of the incretin hormone, glucagon-like peptide-1 (GLP-1) correlate with an increased insulin response to carbohydrate intake in animals with EMS.
|
29404215 |
2018 |
Hyperinsulinism
|
0.400 |
Biomarker
|
disease |
BEFREE |
Semaglutide treatment significantly lowered fasting concentrations of glucose and glucagon, and increased insulin vs placebo (estimated treatment ratio: 0.95 [95% confidence interval: 0.91, 0.98]; 0.86 [0.75, 0.98]; 1.45 [1.20, 1.75], respectively).
|
28941314 |
2018 |
Hyperinsulinism
|
0.400 |
Biomarker
|
disease |
BEFREE |
Activation of G-protein-coupled receptors on L-cells by SCFA promotes the release of glucagon-like peptide-1 and peptide YY resulting in increased insulin and decreased glucagon secretion, and suppressed appetite.
|
29037268 |
2018 |
Hyperinsulinism
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Consistently, GLP-1 decreased CHOP expression and increased insulin stimulated AKT phosphorylation (p-AKT) in thapsigargin, a ER stress inducer, treated white fat cells differentiated from visceral stromal vascular fraction.
|
30459598 |
2018 |
Hyperinsulinism
|
0.400 |
Biomarker
|
disease |
BEFREE |
They also showed a reduction in pancreatic islets area and percentage of cells stained for insulin, increased the percentage of non-β cells (alpha e delta cells) stained for Ki-67, glucagon, and somatostatin.
|
30366036 |
2018 |
Hyperinsulinism
|
0.400 |
Biomarker
|
disease |
BEFREE |
Increased Insulin Resistance and Glucagon Levels in Mild/Inactive Systemic Lupus Erythematosus Patients Despite Normal Glucose Tolerance.
|
28320046 |
2018 |
Hyperinsulinism
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, B6 mice fed with BA showed elevated insulin levels in serum, accompanied by increased serum glucagon-like peptide-1 and decreased intestinal dipeptidyl peptidase-4.
|
27118489 |
2017 |
Hyperinsulinism
|
0.400 |
Biomarker
|
disease |
BEFREE |
Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production.
|
29117552 |
2017 |
Hyperinsulinism
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here we investigated the mechanism by which glucagon and insulin increased FGF21 gene transcription in primary hepatocyte cultures.
|
28188284 |
2017 |
Hyperinsulinism
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
During physiologic hyperinsulinemia, plasma free fatty acid (FFA) and glucagon levels were clamped at basal values and brain insulin action was blocked, but insulin's direct effects on the liver were left intact.
|
28352665 |
2017 |