|
Gestational Diabetes
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
A case-control study and meta-analysis confirm glucokinase regulatory gene rs780094 is a risk factor for gestational diabetes mellitus.
|
29410004 |
2018 |
|
Gestational Diabetes
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
Our screening criteria allowed for the identification of glucokinase-deficient patients who were diagnosed with gestational diabetes, and these mutations in the GCK gene were not common in Chinese women with gestational diabetes.
|
28371533 |
2018 |
|
Gestational Diabetes
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
In the case of the GCK rs1799884 polymorphism, there was a predominance of the T allele in women with GDM; however, this association reached only borderline statistical significance (p=0.08).
|
28359772 |
2017 |
|
Gestational Diabetes
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
Due to the relationship between GCKRP and GCK, polymorphisms in GCKR are also candidates for genetic association with GDM.
|
27554451 |
2017 |
|
Gestational Diabetes
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
The NSC will refer 6.1% of GDM cases for GCK testing, with more Asian/Indian women referred despite lower disease prevalence.
|
26109503 |
2016 |
|
Gestational Diabetes
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
The association between the glucokinase (GCK)-30G > A polymorphism and GDM susceptibility was assessed using genetic models.
|
25633883 |
2015 |
|
Gestational Diabetes
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
To prospectively determine the prevalence of maturity onset diabetes of the young (MODY) due to glucokinase (GCK) mutations in an American population of women with recent onset diabetes mellitus and gestational diabetes.
|
25012807 |
2015 |
|
Gestational Diabetes
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
GCK monogenic diabetes and gestational diabetes: possible diagnosis on clinical grounds.
|
26043405 |
2015 |
|
Gestational Diabetes
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
The aim of this meta-analysis is to provide a relatively comprehensive picture of the association of the GCK -30G>A polymorphism with GDM and T2DM risk.
|
24520939 |
2014 |
|
Gestational Diabetes
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
The 0.1% of the population with glucokinase monogenic diabetes can be recognized by clinical characteristics in pregnancy: the Atlantic Diabetes in Pregnancy cohort.
|
24550216 |
2014 |
|
Gestational Diabetes
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A, GCK), rs5219 (rs5219" genes_norm="3767">E23K, KCNJ11), rs7754840 (CDKAL1), rs4402960 (IGF2BP2), rs10830963 (MTNR1B), rs1387153 (MTNR1B) and rs1801278 (rs1801278" genes_norm="3667">Gly972Arg, IRS1) were significantly associated with a higher risk of GDM.
|
23690305 |
2013 |
|
Gestational Diabetes
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
These polymorphisms were in or near the following genes: TCF7L2 (rs7903146), MTNR1B (rs10830963), IGF2BP2 (rs4402960), KCNJ11 (rs5219), CDKAL1 (rs7754840), KCNQ1 (rs2237892 and rs2237895) and GCK (rs4607517); while no association was found for PPARG with GDM risk.
|
23029294 |
2012 |
|
Gestational Diabetes
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
We report two women with gestational diabetes mellitus resulting from GCK mutations with hyperglycemia sufficient to merit treatment.
|
22773699 |
2012 |
|
Gestational Diabetes
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
Heterozygous mutations in glucokinase (GCK) are associated with mild fasting hyperglycemia and gestational diabetes mellitus while homozygous or compound heterozygous GCK mutations result in permanent neonatal diabetes mellitus.
|
21978167 |
2012 |
|
Gestational Diabetes
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
Maturity Onset Diabetes of the Young (MODY) due to glucokinase mutations may account for as much as 5% of GDM patients.
|
22145702 |
2012 |
|
Gestational Diabetes
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
A sample of 200 pregnant women classified as healthy (control, N = 100) or with gestational diabetes (N = 100) was analyzed for mutations in the GCK gene.
|
22653590 |
2012 |
|
Gestational Diabetes
|
0.200 |
GeneticVariation
|
phenotype |
LHGDN |
In summary, our results suggest that, because of high costs and time-consuming methods of genetic studies, the investigations of glucokinase gene mutations should be concentrated in women with gestational diabetes without clinical and biochemical features of insulin resistance, but with family history of diabetes in two generations.
|
18159847 |
2007 |
|
Gestational Diabetes
|
0.200 |
GeneticVariation
|
phenotype |
LHGDN |
GCK and HNF1alpha mutations and polymorphisms in Polish women with gestational diabetes.
|
16963153 |
2007 |
|
Gestational Diabetes
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
In addition, common variants in several candidate genes (e.g. potassium inwardly rectifying channel subfamily J, member 11 [KCNJ11], Glucokinase [GCK], Hepatocyte nuclear factor-1alpha [HNF1A] etc.) have been demonstrated to increase the risk of GDM.
|
17346148 |
2007 |
|
Gestational Diabetes
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
The -30G-->A polymorphism of the beta-cell-specific promoter of GCK and the I27L polymorphism of HNF1A seem to increase the risk of GDM in Scandinavian women.
|
16752173 |
2006 |
|
Gestational Diabetes
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Direct sequencing of NEUROD1 was performed in (i) 73 probands with clinical MODY without mutations in hepatocyte nuclear factor (HNF)-4alpha (MODY1), glucokinase (MODY2) and hepatocyte nuclear factor (HNF)-1alpha (MODY3), and (ii) 51 subjects diagnosed with gestational diabetes.
|
16026366 |
2005 |
|
Gestational Diabetes
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
Influence of maternal and fetal glucokinase mutations in gestational diabetes.
|
11483936 |
2001 |
|
Gestational Diabetes
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
Phenotypic selection of subjects with gestational diabetes greatly increases the likelihood of detecting a mutation in the glucokinase gene as previous studies have suggested a prevalence of 2.5% (range 0-6%).
|
10753050 |
2000 |
|
Gestational Diabetes
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
We have screened the glucokinase gene by the polymerase chain reaction (PCR) and denaturing gradient gel electrophoresis (DGGE) in fifteen subjects with clinical characteristics of MODY and one parent with NIDDM, impaired glucose tolerance or gestational diabetes.
|
10694920 |
1998 |
|
Gestational Diabetes
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
In summary, in a cohort of 35 British Caucasian women with gestational diabetes neither missense nor nonsense glucokinase mutations were found.
|
9088772 |
1997 |