GCKR, glucokinase regulator, 2646

N. diseases: 136; N. variants: 23
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011847
Disease: Diabetes
Diabetes
0.180 GeneticVariation disease GWASCAT Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria. 31511532 2019
CUI: C0011847
Disease: Diabetes
Diabetes
0.180 Biomarker disease BEFREE Elucidating the molecular basis of ligand-mediated control over the GCK-GKRP interaction is expected to impact the development and future refinement of therapeutic agents for diabetes and cardiovascular disease, which result from improper GKRP regulation of GCK. 28516783 2017
CUI: C0011847
Disease: Diabetes
Diabetes
0.180 GeneticVariation disease GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247 2016
CUI: C0011847
Disease: Diabetes
Diabetes
0.180 GeneticVariation disease BEFREE No significant interactions between the type of diabetes and the GCKR or G6PC2 genotype were detected. 24918535 2014
CUI: C0011847
Disease: Diabetes
Diabetes
0.180 GeneticVariation disease BEFREE In a multivariate-adjusted model, a significant association was observed only for rs780094 in the glucokinase regulator (GCKR) gene: odds ratios for pancreatic cancer were 1.00 for TT, 1.35 (95% CI, 0.71-2.58) for CT, and 2.14 (95% CI, 1.12-4.08) for CC genotypes (P trend = 0.01) and did not change after the adjustment for diabetes. 22015968 2012
CUI: C0011847
Disease: Diabetes
Diabetes
0.180 GeneticVariation disease BEFREE In the Danish MONICA study four gene variants were significantly associated with incident CVD independently of known diabetes status at baseline; SLC2A2 rs11920090 (HR 1.147, 95% CI 1.027-1.283 , P = 0.0154), C2CD4A rs7172432 (1.112, 1.027-1.205 , P = 0.0089), GCKR rs780094 (1.094, 1.007-1.188 , P = 0.0335) and C2CD4B rs11071657 (1.092, 1.007-1.183 , P = 0.0323). 23185617 2012
CUI: C0011847
Disease: Diabetes
Diabetes
0.180 GeneticVariation disease BEFREE We genotyped the two GCKR SNP in 3346 DPP participants and evaluated association with progression to diabetes and both baseline levels and changes in triglycerides, homeostasis model assessment of insulin resistance (HOMA-IR), oral disposition index, and inflammatory markers along with their interactions with DPP interventions. 21525158 2011
CUI: C0011847
Disease: Diabetes
Diabetes
0.180 Biomarker disease BEFREE We propose that GCKR is a susceptibility gene in Japanese families with clustered diabetes. 21236713 2011
CUI: C0011847
Disease: Diabetes
Diabetes
0.180 GeneticVariation disease BEFREE The findings also suggest that the minor alleles of functional GCKR may protect against diabetes and the metabolic syndrome in adults. 21511510 2011
CUI: C0011847
Disease: Diabetes
Diabetes
0.180 GeneticVariation disease BEFREE We found that: (i) genotypes, including those of APOA5 S19W, APOA5 -1131T > C, APOE, GCKR, TRIB1 and TBL2/MLXIPL, were significantly associated with severe HTG; (ii) odds ratios for these genetic variables were significant in both univariate and multivariate regression analyses, irrespective of the presence or absence of diabetes or obesity; (iii) a significant fraction-about one-quarter-of the explained variation in disease status was associated with these genotypes. 18596051 2008