|
Non-alcoholic Fatty Liver Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
Studies that used common variants in PNPLA3, TM6SF2 and GCKR as instruments to investigate the relationship between NAFLD and coronary artery disease (CAD) have reported contrasting results.
|
31713012 |
2020 |
|
Non-alcoholic Fatty Liver Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Among the eleven genotyped SNPs, the genetic variants in TM6SF2 rs58542926 (OR = 4.13, p = 0.002), GCKR rs1260326 (OR = 1.53, p = 0.003), PNPLA3 rs738409 (OR = 1.58, p = 0.004) and ELOVL2 rs2236212 (OR = 1.34, p = 0.047) were significantly associated with a higher risk of NAFLD.
|
31255630 |
2019 |
|
Non-alcoholic Fatty Liver Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Here, we accessed the seven polymorphisms of rs1260326, rs780094 in GCKR, rs2954021 near TRIB1, rs2228603 in NCAN, rs58542926 in TM6SF2, rs12137855 near LYPLAL1, and rs10883437 near CPN1 on NAFLD susceptibility in the Uygur population.
|
30646922 |
2019 |
|
Non-alcoholic Fatty Liver Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Three of the 14 SNPs were significantly associated with paediatric NAFLD after FDR adjustment, rs738409 (PNPLA3, P = 2.80 × 10<sup>-06</sup> ), rs1044498 (ENPP1, P = 0.0091) and rs780094 (GCKR, P = 0.0281).
|
30444569 |
2019 |
|
Non-alcoholic Fatty Liver Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A weighted-genetic risk score combining PNPLA3, GCKR, and TM6SF2 risk alleles was associated with almost eightfold higher risk of NAFLD.
|
30710115 |
2019 |
|
Non-alcoholic Fatty Liver Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
New polymorphisms, such as those in PNPLA3, TM6SF2, MBOAT7 and GCKR, have been identified and used to predict the development and severity of NAFLD in both adults and children, and their interaction with environmental factors has been elucidated.
|
31278377 |
2019 |
|
Non-alcoholic Fatty Liver Disease
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Risk estimation model for nonalcoholic fatty liver disease in the Japanese using multiple genetic markers.
|
29385134 |
2018 |
|
Non-alcoholic Fatty Liver Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Because PNPLA3 rs738409, GCKR rs780094 and TM6SF2 rs58542926 variants are known to confer susceptibility to NAFLD, we assessed the influence of MBOAT7 rs641738 on hepatic steatosis, and serum levels of CK-18 fragment (a biomarker of hepatocellular injury and apoptosis for NAFLD) after adjusting the effects of PNPLA3, GCKR and TM6SF2 polymorphisms.
|
29314568 |
2018 |
|
Non-alcoholic Fatty Liver Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Among individual variants, rs1260326 in GCKR and rs641738 in MBOAT7 (recessive), rs58542926 in TM6SF2 and rs738409 in PNPLA3 (dominant) emerged as associated to NAFLD, with PNPLA3 rs738409 being the strongest predictor (OR 3.12, 95% CI, 1.8-5.5, P < 0.001).
|
29487372 |
2018 |
|
Non-alcoholic Fatty Liver Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A modified response of NAFLD patients with non-significant fibrosis in nutritional counseling according to GCKR rs1260326.
|
28695325 |
2018 |
|
Non-alcoholic Fatty Liver Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
During the last years, common variants in PNPLA3, TM6SF2, MBOAT7 and GCKR have been demonstrated to predispose to the full spectrum of NAFLD pathology by facilitating hepatic fat accumulation in the presence of environmental triggers.
|
30659533 |
2018 |
|
Non-alcoholic Fatty Liver Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our study aimed to investigate the feasibility of a new index comprehensive index (CI), consisting of 6 serum biomarkers and anthropometric parameters through multivariate logistic regression analysis, to the earlier detection of NAFLD, and the diagnostic value of 5 SNPs (S1: rs2854116 of apolipoprotein C3 [APOC3], S2: rs4149267 of ATP-binding cassette transporter [ABCA1], S3: rs13702 of lipoprotein lipase [LPL], S4: rs738409 of protein 3 [patatin-like phospholipase domain containing protein 3 (PNPLA3)], S5: rs780094 of glucokinase regulatory protein gene [GCKR]) for NAFLD were also explored.
|
29595690 |
2018 |
|
Non-alcoholic Fatty Liver Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Here we show that adiposity significantly amplifies the effect of three sequence variants (encoding PNPLA3 p.I148M, TM6SF2 p.E167K, and GCKR p.P446L) associated with nonalcoholic fatty liver disease (NAFLD).
|
28436986 |
2017 |
|
Non-alcoholic Fatty Liver Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In humans, changes in glucokinase expression and activity are associated with poorly controlled type 2 diabetes and with nonalcoholic fatty liver disease, and a common variant of GKRP with altered binding affinity for glucokinase is associated with increased blood and liver lipids and other metabolic traits that implicate a role for GKRP in maintaining intrahepatic metabolite homeostasis.
|
27146014 |
2016 |
|
Non-alcoholic Fatty Liver Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Although studies have suggested that rs780094, a common variant in the glucokinase regulatory (GCKR) gene to be associated with type 2 diabetes, obesity, and their related traits, the genetic basis of the association between GCKR rs780094 and nonalcoholic fatty liver disease (NAFLD) is still being examined.
|
25167786 |
2015 |
|
Non-alcoholic Fatty Liver Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
Genome-wide association studies have identified single nucleotide polymorphisms (SNPs) near/in PNPLA3, NCAN, LYPLAL1, PPP1R3B, and GCKR genes associated with non-alcoholic fatty liver disease (NAFLD) mainly in individuals of European ancestry.
|
25597287 |
2015 |
|
Non-alcoholic Fatty Liver Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
At multivariate logistic regression analysis in the entire NAFLD cohort, the presence of significant liver fibrosis (>F1) was independently linked to high HOMA (OR 1.12, 95% CI 1.01-1.23, p = 0.02), NAFLD activity score ≥ 5 (OR 4.09, 95% CI 2.45-6.81, p<0.001), and GCKR C>T SNP (OR 2.06, 95% CI 1.43-2.98, p<0.001).
|
24498332 |
2014 |
|
Non-alcoholic Fatty Liver Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
GCKR rs780094 was also associated with an increased ratio of visceral to subcutaneous fat area in the patients with nonalcoholic fatty liver disease.
|
24785259 |
2014 |
|
Non-alcoholic Fatty Liver Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
By studying the genetic variants of obese Taiwanese children, we confirmed that the genetic variants in GCKR rs780094 and PNPLA3 rs738409, but not in NCAN rs2228603, LYPLAL1 rs12137855, and PPP1R3B rs4240624, are associated with an increased risk of NAFLD.
|
24477042 |
2014 |
|
Non-alcoholic Fatty Liver Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
In contrast to full-length KLF6, splice variant KLF6-SV1 increases in NAFLD hepatocytes and inversely correlates with glucokinase regulatory protein, which negatively regulates GCK activity.
|
22095588 |
2012 |
|
Non-alcoholic Fatty Liver Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation in GCKR gene rs780094 polymorphism contributes to the risk of NAFLD in Chinese people.
|
20625834 |
2011 |