GCKR, glucokinase regulator, 2646

N. diseases: 136; N. variants: 23
Disease: Metabolic Syndrome X ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.200 GeneticVariation disease BEFREE The main factors associated with IR were body fat percentage and triglycerides; SNP for the ABCA1 gene was related to MS, obesity and low HDL-C; SNP for GCKR gene was related to high fasting glycemia, while APOAV SNP was related with MS, hypertriglyceridemia and low HDL-C. Our findings show that the Mexican genetic predisposition to NCD affects young adults, who can suffer MS, obesity and IR. 31796261 2020
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.200 GeneticVariation disease GWASCAT Multiple genotype-phenotype association study reveals intronic variant pair on SIDT2 associated with metabolic syndrome in a Korean population. 30382898 2018
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.200 GeneticVariation disease GWASCAT New Common and Rare Variants Influencing Metabolic Syndrome and Its Individual Components in a Korean Population. 29632305 2018
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.200 GeneticVariation disease BEFREE The intragenic rs1244979, rs2815752 in NEGR1 gene, and rs780094 in GCKR gene were genotyped and CNVs were determined by droplet digital polymerase chain reaction (ddPCR) in PCOS patients (n = 153) and controls without metabolic syndrome (n = 142). 27878529 2017
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.200 GeneticVariation disease BEFREE Variants of the glucokinase regulator (GCKR) gene are associated with metabolic syndrome (MetS). 26799416 2016
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.200 GeneticVariation disease BEFREE Our aim was to investigate: i) the relationship between the GCKR rs1260326 (rs1260326" genes_norm="2646">Pro446Leu) polymorphism and parameters of the MetS; and ii) a potential influence of n-3 and n-6 LC-PUFA levels on this relationship in the HELENA study (1,155 European adolescents). 26136510 2015
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.200 GeneticVariation disease BEFREE Association of polymorphisms in GCKR and TRIB1 with nonalcoholic fatty liver disease and metabolic syndrome traits. 24785259 2014
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.200 GeneticVariation disease GWASDB Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. 22399527 2012
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.200 GeneticVariation disease GWASCAT Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. 22399527 2012
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.200 GeneticVariation disease GWASCAT A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. 21386085 2011
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.200 GeneticVariation disease BEFREE We have demonstrated a significant interaction between the GCKR rs1260326-P446L polymorphism and plasma n-3 PUFA levels modulating insulin resistance and inflammatory markers in MetS subjects. 21674002 2011
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.200 GeneticVariation disease BEFREE The findings also suggest that the minor alleles of functional GCKR may protect against diabetes and the metabolic syndrome in adults. 21511510 2011
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.200 GeneticVariation disease BEFREE Our results support that rs780094 and rs1260326 functional variants of the GCKR gene are inversely associated with serum triglycerides and fasting plasma glucose levels, as it was already reported for diabetic and metabolic syndrome patients in some other populations. 21114848 2010
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.200 GeneticVariation disease BEFREE GCKR-L446 carriers are protected against type 2 diabetes despite higher triglyceride levels and risk of dyslipidemia, which suggests a potential molecular mechanism by which these two components of the metabolic syndrome can be dissociated. 18556336 2008
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.200 GeneticVariation disease BEFREE A polymorphism in the GCKR gene predicted dyslipidaemia (rs1260326, OR 1.15, 95% CI 1.09-1.22, p < 0.00001) but not the metabolic syndrome. 18853134 2008