GCKR, glucokinase regulator, 2646

N. diseases: 136; N. variants: 23
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Non-Insulin-Dependent
0.500 AlteredExpression disease BEFREE The expression levels of the GCKR gene and lncRNA (ENST00000588707.1 and TCONS_00004187) in the T2DM group and control group were verified by real-time PCR. 31756311 2020
Diabetes Mellitus, Non-Insulin-Dependent
0.500 GeneticVariation disease GWASCAT Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population. 30718926 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.500 GeneticVariation disease GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.500 GeneticVariation disease BEFREE The purpose of this study was to evaluate the effect of single-nucleotide polymorphisms (SNPs) of the GCKR and G6PC2 genes on risk for type 2 diabetes and the SNP-SNP and haplotype-based interactions between these genes. 30055620 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.500 Biomarker disease BEFREE We demonstrate that Sirt2-dependent GKRP deacetylation improves impaired HGU and suggest that it may be a therapeutic target for type 2 diabetes. 29296001 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.500 GeneticVariation disease BEFREE Association of type 2 diabetes susceptible genes GCKR, SLC30A8, and FTO polymorphisms with gestational diabetes mellitus risk: a meta-analysis. 30091126 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.500 GeneticVariation disease GWASCAT Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. 29632382 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.500 GeneticVariation disease GWASCAT Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes. 30054458 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.500 Biomarker disease BEFREE GCKR was associated with protection against type 2 diabetes (T2D) in MAs, and with hypertriglyceridemia and protection against low HDL Cholesterol (HDL-C) levels in MEZs. 30176313 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.500 GeneticVariation disease BEFREE Although the influence of a common variant in the glucokinase regulatory gene (GCKR rs780094) in type 2 diabetes mellitus has been well documented, less data however, is available of its role in gestational diabetes mellitus (GDM). 29410004 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.500 GeneticVariation disease GWASCAT Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease. 28869590 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.500 GeneticVariation disease BEFREE GWAS signals close to the glucokinase regulatory protein gene (GCKR) have been reported for lipid and glucose metabolism traits and the risk of T2D. 28683826 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.500 GeneticVariation disease BEFREE No associations between genetic variants of KLF14 rs972283, GCKR rs780094 or MTNR1B rs10830963 and T2DM were detected. 26927145 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.500 GeneticVariation disease BEFREE In this study, we set out to determine whether GCKR rs1260326 polymorphism was associated with liver fat content in patients with type 2 diabetes. 25976242 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.500 GeneticVariation disease BEFREE In humans, changes in glucokinase expression and activity are associated with poorly controlled type 2 diabetes and with nonalcoholic fatty liver disease, and a common variant of GKRP with altered binding affinity for glucokinase is associated with increased blood and liver lipids and other metabolic traits that implicate a role for GKRP in maintaining intrahepatic metabolite homeostasis. 27146014 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.500 GeneticVariation disease BEFREE We investigated whether a 1-year intensive lifestyle intervention (ILI) for weight loss would avert the unfavorable cardiometabolic effects associated with GCKR Leu446Pro when compared with a diabetes mellitus support and education arm in overweight/obese individuals with type 2 diabetes mellitus with triglyceride (n=3214) and CRP (n=1411) data participating in a randomized lifestyle intervention study for weight loss, Action for Health in Diabetes Mellitus (Look AHEAD). 26578543 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.500 Biomarker disease BEFREE Given that acetylated GKRP may affiliate with type-2 diabetes mellitus (T2DM), understanding the mechanism of GKRP acetylation in the liver could reveal novel targets within the GK-GKRP pathway, for treating T2DM and other metabolic pathologies. 26620281 2015
Diabetes Mellitus, Non-Insulin-Dependent
0.500 GeneticVariation disease BEFREE Although studies have suggested that rs780094, a common variant in the glucokinase regulatory (GCKR) gene to be associated with type 2 diabetes, obesity, and their related traits, the genetic basis of the association between GCKR rs780094 and nonalcoholic fatty liver disease (NAFLD) is still being examined. 25167786 2015
Diabetes Mellitus, Non-Insulin-Dependent
0.500 GeneticVariation disease BEFREE Recently, genome-wide association studies (GWASs) have shown that variants in the gene encoding GKRP protect against T2DM and kidney disease but predispose to gout, nonalcoholic fatty liver disease, and dyslipidemia. 26432016 2015
Diabetes Mellitus, Non-Insulin-Dependent
0.500 GeneticVariation disease BEFREE The T2D risk alleles of rs972283 near KLF14 and rs11634397 near ZFAND6 were associated with a higher risk for elevated triglycerides (rs972283: 1.11 (1.02, 1.24), P = 1.46 × 10-2; rs11634397: 1.14 (1.00, 1.29), P = 4.66 × 10-2), while the T2D risk alleles of rs780094 in GCKR and rs7903146 in TCF7L2 were related to a lower risk of elevated triglycerides (rs780094: 0.86 (0.80, 0.93), P = 1.35 × 10-4; rs7903146: 0.82 (0.69, 0.98), P = 3.18 × 10-2). 26599349 2015
Diabetes Mellitus, Non-Insulin-Dependent
0.500 GeneticVariation disease BEFREE Three of the identified loci (CELSR2, HNF1A, and GCKR) were significantly associated with T2D, of which the association with the CELSR2 locus has not been shown previously. 25599387 2015
Diabetes Mellitus, Non-Insulin-Dependent
0.500 GeneticVariation disease BEFREE Among Caucasian women, GDM was associated with carriage of TCF7L2 rs7901695, MTNR1B rs10830963 and GCKR rs780094 alleles that are associated with T2DM and fasting glucose in nonpregnant populations. 23456907 2014
Diabetes Mellitus, Non-Insulin-Dependent
0.500 GeneticVariation disease BEFREE To investigate this inconsistency, we performed a meta-analysis of 19 studies involving a total of 298,977 subjects for GCKR rs780094 to evaluate its effect on genetic susceptibility for T2D. 23307301 2013
Diabetes Mellitus, Non-Insulin-Dependent
0.500 GeneticVariation disease BEFREE Our meta-analyses demonstrated that GCKR rs780094 variant confers high cross-ethnicity risk for the development of T2DM, while significant associations between GCK, MTNR1B and G6PC2 variants and T2DM risk are limited to Caucasians. 23840762 2013
Diabetes Mellitus, Non-Insulin-Dependent
0.500 GeneticVariation disease BEFREE Our results revealed that seven index SNPs at the TCF7L2, KLF14, KCNQ1, ADCY5, CDKAL1, JAZF1, and GCKR loci were significantly associated with T2D (P < 0.05). 23193183 2013